Effects of previous ovarian drilling on cumulative ongoing pregnancy rates among patients with polycystic ovarian syndrome undergoing in vitro fertilization

Cai, Jiali; Liu, Lanlan; Sun, Lingbin; Sha, Aihua; Jiang, Xiaoming; Ren, Jianzhi

doi:10.1016/j.ijgo.2016.03.008

Cited by 7 publications

(5 citation statements)

References 26 publications

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“…But the same study results disagreed with our results as regard the percentage of canceled embryo transfer as they found that the rate of cancelled embryo transfer was significantly higher among patients in no LOD group in comparison with the LOD group (P-value= 0.016) (16).…”

Section: Discussioncontrasting

confidence: 99%

“…Cai, et al [16] , their results came in agreement with our current study regarding the number and quality of embryos transferred (no significant difference in percentages of patients in both study groups).…”

Section: Discussionsupporting

confidence: 93%

“…Also in disagreement with our study, a retrospective study by Cai et al [16] , performed to determine if history of LOD was associated with changes in cumulative ongoing pregnancy rates among patients with PCOS undergoing IVF. The study included 110 patients in the LOD group, 127 patients in the no LOD group and 990 patients in the age matched group.…”

Section: Discussioncontrasting

confidence: 88%

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Effect of Laparoscopic Ovarian Drilling on Outcomes of In-Vitro Fertilization in Clomiphene-Resistant Women with Polycystic Ovary Syndrome

Sammour

Abuelghar

Kamel

et al. 2022

Evidence Based Women's Health Journal

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Background:The polycystic ovarian syndrome is associated with anovulation and infertility. Recently the laparoscopic ovarian drilling (LOD) has been used as a surgical treatment for ovulation in women with polycystic ovarian syndrome (PCOS), although its mechanism and outcomes are still unclear. The purpose of this study is to evaluate the LOD effect before in vitro fertilization (IVF) / intracytoplasmic sperm injection (ICSI) in clomiphene-resistant women with PCOS. Objective: To evaluate the effect of LOD on the outcome of IVF/ICSI cycle in Clomiphene-Resistant women with PCOS as regards pregnancy rate. Patients and Methods: The current study, included a total of 88 women with history of clomiphene-resistant PCOS, who had been distributed into two groups: Group A (N=44): clomiphene-resistant PCOS women who has history of LOD at least 6 months to 3 years before IVF/ICSI. Group B (N=44): clomiphene-resistant PCOS women without history of drilling. All women were from 20 to 35 years old with at least one year infertility and BMI <30, and none of them has history of previous IVF/ICSI or history of any chronic disease such as thyroid disorder, DM and sever endometriosis. Results: A significant decrease was observed in the number of AFC among patients with history of LOD than among patients in no LOD group. In our present study, regarding hormonal profile (FSH, LH, E2, PRL & TSH), despite that the serum concentration of LH and FSH were lower among patients in LOD group than in no LOD group but this difference did not reach significance. The chemical and clinical pregnancy rate as the primary outcome were significantly higher among women with history of than among women with no history of LOD. As regard the incidence of OHSS, known as a potential lifethreatening disorder there was no statistical difference between both study groups. Conclusion: LOD is method of treatment of PCO females with failure medical treatments (clomiphene-resistant). Clinical pregnancy rate was significantly higher in women with history of LOD than among women with no history of LOD (34.1% and 15.9% respectively).

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Section: Discussioncontrasting

confidence: 99%

Section: Discussionsupporting

confidence: 93%

Section: Discussioncontrasting

confidence: 88%

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Effect of Laparoscopic Ovarian Drilling on Outcomes of In-Vitro Fertilization in Clomiphene-Resistant Women with Polycystic Ovary Syndrome

Sammour

Abuelghar

Kamel

et al. 2022

Evidence Based Women's Health Journal

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“…In cases of isolated CC-resistant PCOS, drilling can be proposed before a medical ovulation induction treatment. In cases of associated infertility factors it is more difficult to pinpoint the best time for ovarian drilling [[42], [43], [44]].…”

Section: Discussionmentioning

confidence: 99%

Ovarian drilling in polycystic ovary syndrome: Long term pregnancy rate

Debras

Fernandez

Neveu

et al. 2019

European Journal of Obstetrics & Gynecology and Reproductiv

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Objective To report long term pregnancy rate in polycystic ovary syndrome (PCOS) treated by ovarian drilling. To evaluate predictive factors of pregnancy and possibility of a second drilling. Design Retrospective, observational, multicenter study. Setting Gynecologic departments of two teaching’s hospitals. Patients All infertile women with PCOS who were treated by ovarian drilling from 2004 to 2013. The Rotterdam criteria were applied to define PCOS. Intervention(s) Surgical ovarian drilling by laparoscopy and trans vaginal hydro laparoscopy. Main Outcome Measure(s) The primary endpoint was pregnancy rate after ovarian drilling. The secondary endpoints were the predictive factors of pregnancy and the possibility of a second ovarian drilling. Results 289 women were included in the study. The mean follow-up period was 28.4 months (25.3–31.5). A pregnancy was obtained in at least 137 (47.4%) women after a drilling, and 71 (51.8%) of these pregnancies were spontaneous, 48 (16.6%) women achieved at least two pregnancies after drilling, and 27 (56.3%) of these were spontaneous. The predictive factors for effectiveness were a normal body mass index (BMI), an infertility period of less than three years, an AFC of less than 50, and an age of less than 35. Second drillings were performed on 33 women. Among them, 19 (57.6%) achieved at least one pregnancy, and 10 (52.6%) of these were spontaneous. It appeared that a second drilling was effective either when the first drilling had been successful (pregnancy achieved after drilling) or when it had failed in cases of high AFC (greater than 55). Conclusion Ovarian drilling permitted to obtain spontaneous pregnancy for women with PCOS. This surgery could have durably effect permitted to obtain more than one pregnancy.

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“…Another retrospective study was conducted by Cai et al 70 to determine if history of undergoing LOD affects cumulative ongoing pregnancy rates following IVF in patients with PCOS. The study included 110 patients in the LOD group, 127 patients in the no-LOD group, and 990 patients in the age-matched group.…”

mentioning

confidence: 99%

Competing Endoscopic Surgeries in the Era of Assisted Reproductive Technologies: Evidence and Practice

Dawood¹,

Omar²

2017

Gynecol Obstet Res Open J

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Effects of previous ovarian drilling on cumulative ongoing pregnancy rates among patients with polycystic ovarian syndrome undergoing in vitro fertilization

Abstract: LOD could compromise cumulative ongoing pregnancy rates during subsequent in vitro fertilization.

Cited by 7 publications

References 26 publications

Effect of Laparoscopic Ovarian Drilling on Outcomes of In-Vitro Fertilization in Clomiphene-Resistant Women with Polycystic Ovary Syndrome

Effect of Laparoscopic Ovarian Drilling on Outcomes of In-Vitro Fertilization in Clomiphene-Resistant Women with Polycystic Ovary Syndrome

Ovarian drilling in polycystic ovary syndrome: Long term pregnancy rate

Competing Endoscopic Surgeries in the Era of Assisted Reproductive Technologies: Evidence and Practice

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