Effects of probiotic and alpha-lipoic acid supplements, separately or in combination on the anthropometric indicators and maintenance of weight in overweight individuals

Abstract

Background & aims: Weight loss after proper diet is one of the main topics in nutrition. This study was designed to evaluate the effects of probiotic and alpha-Lipoic acid (ALA) supplements on the anthropometric indicators and maintenance of weight in overweight individuals. Methods: This study consisted of two phases of weight loss (8 weeks) and weight maintenance (16 weeks). Eighty-eight overweight participants were randomly divided into 4 groups in phase 1: isocaloric diet with probiotic (500 mg), an isocaloric diet with ALA (600 mg) and probiotic, an isocaloric diet with ALA and isocaloric diet with placebo. In phase 2, participants received a normal diet with the mentioned supplements. In the beginning, end of the phase 1, and at the end of phase 2, weight, body mass index (BMI), waist circumference (WC), hip circumference (HC), body fat percentage, and blood pressure (BP) were measured. Also, 10 cc blood samples were taken from subjects to measure C-reactive protein (CRP). Data was analyzed using SPSS software. Results: At the end of the two phases, the differences of changes in the probiotic þ ALA group was significant in weight, WC, and CRP factors when compared to the other groups (P < 0.05). Also, at the end of the study, maintain a reduced weight was significantly higher in the probiotic þ ALA group than in the other groups (P < 0.05). Conclusion: According to findings, probiotics and ALA supplementation with normal diet help to maintain decreased weight after adhering to a weight loss diet. This may be due to the reduction of inflammation. Trial registration: (IRCT20141025019669N10).

Beneficial effects of the probiotics and synbiotics supplementation on anthropometric indices and body composition in adults: A systematic review and meta‐analysis

“…The general characteristics of the included studies are outlined in Table S4. Trials were published between 1996 and 2023, and were carried out in Asia, 12,27–31,77–81,84–229 Europe, 230–262 America,…”

The effects of alpha lipoic acid (ALA) supplementation on blood pressure in adults: a GRADE-assessed systematic review and dose-response meta-analysis of randomized controlled trials

“…Eligible trials were published between 1997 and 2021. The studies were performed in Iran ( 28 , 31 , 40 , 42 ), United States ( 41 , 45 , 47 ), Mexico ( 17 ), Italy ( 43 ), Korea ( 44 ), and Germany ( 46 ). The intervention duration of selected RCTs ranged from 8 to 48 weeks, with a sample size ranging from 12 to 155 participants.…”

Clinically Effective Molecules of Natural Origin for Obesity Prevention or Treatment

“…Clinical trials with α-lipoic acid treatment have shown a statistically significant short-term reductions in weight, BMI, body fat, and waist circumference, compared to placebo [ 218 , 219 , 220 , 221 ]. Table 11 shows the clinical effects of α-lipoic acid on obesity and related comorbidities, according to clinical trials and systematic reviews with meta-analyses of clinical trials found in the scientific literature.…”