Effects of Probiotic-Enriched Minas Cheese (Lactobacillus acidophilus La-05) on Cardiovascular Parameters in 5/6 Nephrectomized Rats

da Silva Costa, Nathalia; de Araujo, Joana Ramos; da Silva Melo, Manuela Fernandes; da Costa Mota, Jéssica; Almeida, Patricia Pereira; Coutinho-Wolino, Karen Salve; Da Cruz, Beatriz Oliveira; Brito, Michele Lima; de Souza Carvalho, Thaís; Barreto-Reis, Emanuelle; de Luca, Beatriz Gouvêa; Mafra, Denise; Magliano, D.’Angelo Carlo; de Souza Abboud, Renato; Rocha, Ramon Silva; da Cruz, Adriano Gomes; de Toledo Guimarães, Jonas; Stockler-Pinto, Milena Barcza

doi:10.1007/s12602-023-10173-4

Cited by 1 publication

(1 citation statement)

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“…The appropriate or effective dose of probiotics for overall health, gut microbiota, bowel function, and immune strength is a gap in the research [15]. Doses of around 1 × 10 9 CFU/day (one billion CFU) have been used in studies to prevent or treat disrupted gut microbiota [16][17][18]. Given the interactions between the host and the microbiome, it has been suggested that gender may be a key aspect that can influence how probiotics may exert their effects on the gut microbiota in a host system [19].…”

Section: Introductionmentioning

confidence: 99%

A Mix of Potentially Probiotic Limosilactobacillus fermentum Strains Alters the Gut Microbiota in a Dose- and Sex-Dependent Manner in Wistar Rats

Carneiro dos Santos,

Carvalho,

Cruz Neto

et al. 2024

Microorganisms

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Multi-strain Limosilactobacillus (L.) fermentum is a potential probiotic with reported immunomodulatory properties. This study aimed to evaluate the composition, richness, and diversity of the gut microbiota in male and female rats after treatment with a multi-strain of L. fermentum at different doses. Thirty rats (fifteen male and fifteen female) were allocated into a control group (CTL), a group receiving L. fermentum at a dose of 108 CFU (Lf-108), and a group receiving L. fermentum at a dose of 1010 CFU (Lf-1010) for 13 weeks. Gut microbiota and serum cytokine levels were evaluated after L. fermentum treatment. Male CTL rats had a lower relative abundance of Bifidobacteriaceae and Prevotella and a lower alpha diversity than their female CTL counterparts (p < 0.05). In addition, male CTL rats had a higher Firmicutes/Bacteroidetes (F/B) ratio than female CTL rats (p < 0.05). In female rats, the administration of L. fermentum at 108 CFU decreased the relative abundance of Bifidobacteriaceae and Anaerobiospirillum and increased Lactobacillus (p < 0.05). In male rats, the administration of L. fermentum at 1010 CFU decreased the F/B ratio and increased Lachnospiraceae and the diversity of the gut microbiota (p < 0.05). The relative abundance of Lachnospiraceae and the alpha-diversity of gut microbiota were negatively correlated with serum levels of IL1β (r = −0.44) and TNFα (r = −0.39), respectively. This study identified important changes in gut microbiota between male and female rats and showed that a lower dose of L. fermentum may have more beneficial effects on gut microbiota in females, while a higher dose may result in more beneficial effects on gut microbiota in male rats.

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