Effects of Probiotic Enterococci and Glatiramer Acetate on the Severity of Experimental Allergic Encephalomyelitis in Rats

Абдурасулова, И. Н.; Ermolenko, E. I.; Мацулевич, А. В.; Abdurasulova, K O; Tarasova, E. Yu.; Kudryavtsev, I. V.; Бисага, Г Н; Suvorov, A. N.; Клименко, В. М.

doi:10.1007/s11055-017-0484-1

Cited by 7 publications

(6 citation statements)

References 56 publications

Supporting

Mentioning

Contrasting

Unclassified

Order By: Relevance

“…2016b; Abdurasulova et al . 2017). According to our analysis, the outcome varied based on the probiotic strain.…”

Section: Resultsmentioning

confidence: 99%

“…After a full-text review, 25 articles were discarded. Eventually, 15 studies had the inclusion criteria and were selected for the meta-analysis (Maassen et al 1998;Maassen et al 2003;Baken et al 2006;Kobayashi et al 2010;Lavasani et al 2010;Takata et al 2011;Kobayashi et al 2012;Kwon et al 2013;Abdurasulova et al 2016a;Abdurasulova et al 2016b;Salehipour et al 2017;Secher et al 2017;Consonni et al 2018;Libbey et al 2018;Yamashita et al 2018;He et al 2019). It should be mentioned, in some of the selected studies, more than one probiotic bacterium or animal species have been examined, so 25 dependent subgroups were obtained from 15 studies.…”

Section: Accepted Articlementioning

confidence: 99%

“…Multiple sclerosis (MS) is one of the most common autoimmune and chronic diseases of the central nervous system (CNS) that is a major cause of work disability (Abdurasulova et al . 2017). The MS develops due to the destruction of myelin sheaths of the CNS and is characterized by damage to oligodendrocyte (cells that produce myelin) and neurons and their axons, astrogliosis, inflammatory lesions, and impairment of Blood‐brain barrier integrity (BBB) in young people (Lassmann et al .…”

Section: Introductionmentioning

confidence: 99%

See 2 more Smart Citations

The efficacy of probiotics in experimental autoimmune encephalomyelitis (an animal model for MS): a systematic review and meta‐analysis

Valizadeh

Seghinsara

Chollou³

et al. 2021

Lett Appl Microbiol

View full text Add to dashboard Cite

show abstract

“…2016b; Abdurasulova et al . 2017). According to our analysis, the outcome varied based on the probiotic strain.…”

Section: Resultsmentioning

confidence: 99%

Section: Accepted Articlementioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

See 1 more Smart Citation

The efficacy of probiotics in experimental autoimmune encephalomyelitis (an animal model for MS): a systematic review and meta‐analysis

Valizadeh

Seghinsara

Chollou³

et al. 2021

Lett Appl Microbiol

View full text Add to dashboard Cite

show abstract

“…-0,28 препарата в целом [3]. Подобный феномен, вероятно, наблюдается и при высоком уровне эндогенных энтерококков у пациентов с РС, которые могут снижать эффективность проводимой терапии.…”

Section: Discussionunclassified

“…Выявление этих бактерий в высоком титре именно у пациентов с более тяжелым течением заболевания подтверждает эту точку зрения. Поскольку введение только пробиотических энтерококков в высокой дозе, оказывало благоприятное действие на течение ЭАЭ у животных, сопоставимое с действием ГА [3,10], возможно при высоком уровне эндогенных энтерококков применение иммуномодуляторов не требуется. Вероятность увеличения патогенных популяций Th17 -DP Th17 и Th17/Th22 -возрастет также при низком уровне Lactobacillus spp.…”

Section: Discussionunclassified

Intestinal microbiota composition and peripheral blood Th cell subsets in patients with multiple sclerosis

Абдурасулова

Tarasova

Кудрявцев

et al. 2019

Russian Journal of Infection and Immunity

Self Cite

View full text Add to dashboard Cite

At present, the role of intestinal microbiota in diverse diseases of the central nervous system, including of multiple sclerosis (MS) has been extensively investigated. Self-reactive CD4+ Th1 and Th17 cells specific to myelin-derived antigens play a key role in the MS pathogenesis. Taking into consideration pathogenetic features related to MS development, we examined a relation between intestinal microbiocenosis and abundance of various peripheral blood helper T (Th) cell subsets in MS patients. Objective of the study: to assess prevalence of individual members of the intestinal microbiota in MS patients and analyze a relation with peripheral blood Th cell subsets. Prevalence of symbiotic and opportunistic microbial species was estimated by bacteriological method and real time PCR in 112 MS patients (72 females, 40 males) of varying severity and duration. Th cell subsets (Th1, Th2, Th17, Th1/Th17, Th17/Th22, DP Th17) were analyzed by using multi-color flow cytometry based on Th cell subset-specific surface expression of chemokine receptors. A relationship between individual intestinal microbiota species and severity, duration and rate of MS progression, as well as with the phenotype of immune cells was assessed. It was found that the most significant correlation between percentage of peripheral blood Th cell subsets was observed with prevalence of Lactobacillus spp., Enterococcus spp. and Enterobacter spp. Moreover, prevalence of Enterococcus spp. Th cell composition influenced synergistically or antagonistically together with Enterobacter spp. or Lactobacillus spp., respectively. It is suggested that direct and indirect impact of intestinal microbiota composition on human immune system might contribute to developing novel strategies for treating MS.

show abstract

The importance of gut-brain axis and use of probiotics as a treatment strategy for multiple sclerosis

Kumar

Sahoo

Mehan

et al. 2023

Multiple Sclerosis and Related Disorders

View full text Add to dashboard Cite

Effects of Probiotic Enterococci and Glatiramer Acetate on the Severity of Experimental Allergic Encephalomyelitis in Rats

Cited by 7 publications

References 56 publications

The efficacy of probiotics in experimental autoimmune encephalomyelitis (an animal model for MS): a systematic review and meta‐analysis

The efficacy of probiotics in experimental autoimmune encephalomyelitis (an animal model for MS): a systematic review and meta‐analysis

Intestinal microbiota composition and peripheral blood Th cell subsets in patients with multiple sclerosis

The importance of gut-brain axis and use of probiotics as a treatment strategy for multiple sclerosis

Contact Info

Product

Resources

About