Effects of probiotic fermented milk on symptoms and intestinal flora in patients with irritable bowel syndrome: A randomized, placebo-controlled trial

Søndergaard, Bo; Olsson, Jörgen; Ohlson, Kajsa; Svensson, Ulla; Bytzer, Peter; Ekesbo, Rickard

doi:10.3109/00365521.2011.565066

Cited by 74 publications

(136 citation statements)

References 15 publications

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“…Significant pain alleviation was not found in 16 studies (6,19,20,(22)(23)(24)(25)(26)29,32,34,(36)(37)(38)(39), although a pain alleviation trend was found in 4 studies (5,23,32,37). Both the TG and Studies identified from bibliographic databases n = 252…”

Section: Abdominal Pain or Discomfortmentioning

confidence: 99%

Effect of probiotic species on irritable bowel syndrome symptoms: A bring up to date meta-analysis

Ortiz-Lucas

Tobías

Saz

et al. 2013

Rev. esp. enferm. dig.

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Background and objectives: immune system alteration in irritable bowel syndrome (IBS) patients may be modulated by probiotics. We assessed the efficacy of some probiotic species in alleviating characteristic IBS symptoms.Material and methods: a meta-analysis of all identified randomized controlled trials comparing probiotics with placebo in treating IBS symptoms was performed with continuous data summarized using standardized mean differences (SMDs) with 95% confidence intervals (95% CIs), where appropriate. The random-effects model was employed in cases of heterogeneity; otherwise, fixed-effects models were used.Results: meta-analysis was performed with 10 of 24 studies identified as suitable for inclusion. Probiotics improved pain scores if they contained Bifidobacterium breve (SMD, -0.34; 95% CI, -0.66; -0.02), Bifidobacterium longum (SMD, -0.48; 95% CI, -0.91; -0.06), or Lactobacillus acidophilus (SMD, -0.31; 95% CI, -0.61; -0.01) species. Distension scores were improved by probiotics containing B. breve (SMD, 95% CI, Conclusions: some probiotics are an effective therapeutic option for IBS patients, and the effects on each IBS symptom are likely species-specific. Future studies must focus on the role of probiotics in modulating intestinal microbiota and the immune system while considering individual patient symptom profiles. INTRODUCTIONDefining and treating irritable bowel syndrome (IBS) can be challenging. Among the wide variety of treatment options, probiotics appear to be one of the best options (1). Recently, growing evidence has suggested an alteration in the immune system cell profile of IBS patients and a close relationship between the immune and nervous systems (2,3). Furthermore, several authors have studied the relationship between probiotic intake and blood cytokine levels (4) or changes in fecal microbiota (5,6). Several reviews and meta-analyses that have evaluated the role of probiotics in IBS therapy have concluded that probiotics appear to improve overall IBS symptoms (7-12). However, a meta-analysis that includes any probiotic in the evaluation of symptom relief may not be the best method for assessing the efficacy of specific probiotics (11-13). Therefore, we assessed the efficacy of each specific probiotic species in alleviating characteristic IBS symptoms. Effect of probiotic species on irritable bowel ORIGINAL PAPERSOrtiz-Lucas M, Tobias A, Saz P, Sebastián JJ. Effect of probiotic species on irritable bowel syndrome symptoms: A bring up to date meta-analysis. Rev Esp Enferm

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Section: Abdominal Pain or Discomfortmentioning

confidence: 99%

Effect of probiotic species on irritable bowel syndrome symptoms: A bring up to date meta-analysis

Ortiz-Lucas

Tobías

Saz

et al. 2013

Rev. esp. enferm. dig.

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“…Patients taking probiotics did not have any significant increases in intestinal microbiota or changes in levels of the inflammatory marker C-reactive protein (15). Another study reported that patients taking a probiotic mixture containing B. lactis and those taking placebo had similar improvements in gastrointestinal symptoms after 8 weeks (16). One controlled study observed that a group taking synbiotic yogurt (including B. lactis Bb12 and acacia fiber) had significant improvements and recovery in the initial symptoms of constipation-predominant and diarrhea-predominant IBS than did those taking standard yogurt as a control (17).…”

Section: Discussionmentioning

confidence: 98%

Efficacy of synbiotic, probiotic, and prebiotic treatments for irritable bowel syndrome in children: A randomized controlled trial

Baştürk

Artan²,

Yılmaz³

2020

Turk J Gastroenterol

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“…Ford ; B. infantis 35624 60,61 ; VSL #3 [62][63][64] ; a combination product of L. paracasei subspecies paracasei F19, L. acidophilus La5, and B. lactis Bb12 [65][66][67] ; and the other combination of B. lactis DN-173 010, S. thermophilus, and L. bulgaricus. 68,69 A systematic review of 18 RCTs involving 1806 IBS patients and consensus voting reported a high grade of evidence for the effect of probiotics on abdominal pain, and a good consensus agreement.…”

Section: Global Efficacy Of Probiotics In Irritable Bowel Syndrome: Dmentioning

confidence: 99%

Therapeutic Modulation of Gut Microbiota in Functional Bowel Disorders

Lee

Choi

Ryu

et al. 2017

J Neurogastroenterol Motil

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Functional bowel disorders (FBDs) are functional gastrointestinal disorders with symptoms attributable to the middle or lower gastrointestinal tract. These include irritable bowel syndrome, functional bloating, functional constipation, functional diarrhea, and unspecified FBD. Increasing evidence has emerged of late that intestinal microbiota is involved in the pathogenesis of FBDs. In this review, the therapeutic benefits and future perspectives of the currently available strategies for modifying the gut microbiota in FBDs are described, focusing primarily on irritable bowel syndrome and functional constipation.

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Effects of probiotic fermented milk on symptoms and intestinal flora in patients with irritable bowel syndrome: A randomized, placebo-controlled trial

Abstract: During this 8-week trial gastrointestinal symptoms improved. However, there was no difference between treatment with fermented milk containing probiotics or acidified milk. The effect of probiotics on IBS symptoms remains uncertain and further studies are warranted.

Cited by 74 publications

References 15 publications

Effect of probiotic species on irritable bowel syndrome symptoms: A bring up to date meta-analysis

Effect of probiotic species on irritable bowel syndrome symptoms: A bring up to date meta-analysis

Efficacy of synbiotic, probiotic, and prebiotic treatments for irritable bowel syndrome in children: A randomized controlled trial

Therapeutic Modulation of Gut Microbiota in Functional Bowel Disorders

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