Effects of Probiotic Lactobacillus Casei DN-114 001 in Prevention of Radiation-Induced Diarrhea: Results From Multicenter, Randomized, Placebo-Controlled Nutritional Trial

Multicenter, Phase 3 Trial Comparing Selenium Supplementation With Observation in Gynecologic Radiation Oncology

“…Radiation-induced diarrhea is a common side effect of RT and grossly impairs quality of life. The prophylactic use of different products such as smectite, sucralfate, octreotide, and probiotics has been reported without recommendation for prevention of radiation-induced diarrhea (34)(35)(36)(37)(38). Selenium supplementation yielded significant prevention of diarrhea and thus improved the quality of life in the SG.…”

The vaginal and gastrointestinal microbiomes in gynecologic cancers: A review of applications in etiology, symptoms and treatment

“…The results of these searches were combined, and we identified a total of four relevant primary research articles published in English within the last 10 years (Table 1). All four of these papers examined whether probiotics are effective at reducing radiation-induced diarrhea in gynecologic cancer patients [63][64][65][66]. The first paper was a randomized, double blind, placebo controlled trial of 63 advanced cervical cancer patients that investigated whether a probiotic containing live Lactobacillus acidophilus plus Bifidobacterium bifidum could reduce the incidence of diarrhea as the patients underwent radiotherapy with concurrent cisplatin.…”

The Effects of Concomitant Giardia intestinalis Infection on Acute Gastrointestinal Toxicity in Rats Undergoing Pelvic Irradiation

“…The acute diarrhea was caused by inflammatory alterations by various mechanisms, among which the increased gastrointestinal motility, reduced bile acid reabsorption, and the impaired maturation and depletion of villi with denudation of the mucosa took place (33). In the comparison of the groups, a significant negative impact that radiation therapy has on the histologic structure of the intestine was demonstrated as a result of this study.…”