Effects of probiotic supplementation for the first 6 months of life on allergen‐ and vaccine‐specific immune responses

Taylor, Angie; Hale, J.; Wiltschut, J.; Lehmann, H.; Dunstan, Janet; Prescott, Susan L.

doi:10.1111/j.1365-2222.2006.02553.x

Cited by 67 publications

(38 citation statements)

References 36 publications

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“…The frequency of developing atopic dermatitis in the offspring's of pregnant mothers who received Lactobacillus GG was significantly reduced by 2, 4, and 7 years, by 50%, 44%, and 36% respectively [125][126][127]. Lactobacillus acidophilus strain was not able to produce same result in a different study suggesting the strain specificity [128]. Lactobacillus GG in combination with B. lactis during pregnancy and breastfeeding reduced the risk of atopic eczema and allergic sensitization in child [129], whereas a mixture of probiotics (Lactobacillus GG, L. rhamnosus LC705, B. breve, and Propionibacterium freudenreichii ssp.…”

Section: Probiotics and Allergy And Immune Responsementioning

confidence: 68%

Probiotics: Mechanisms of Action and Clinical Applications

Gogineni¹,

Morrow²,

Malesker³

2013

J Prob Health

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Probiotics are living microorganisms which when taken in adequate amount provides benefit to the host. While this beneficial effect was originally thought to stem from improvements in the intestinal microbial balance, there is now substantial evidence that probiotics can also provide benefits by modulating immune functions. Extrapolation of immunomodulatory effects found in the laboratory and in animal studies with outcomes in human trials presents a difficult challenge. Not all probiotics are created equal and the benefits are strain and dose specific. With newer strain-specific clinical trials and meta-analysis of the clinical trials, the beneficial role of probiotics in certain diseases has been evolving. Some uncertainity still exists with probiotics in other diseases with regard to the therapeutic role, strain-specificity, dosage and duration. Identification of clinical characteristics of effective probiotic strains, their mechanisms of action and testing of probiotic-based treatment may provide the true beneficial effect of probiotics in various disorders.

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Section: Probiotics and Allergy And Immune Responsementioning

confidence: 68%

Probiotics: Mechanisms of Action and Clinical Applications

Gogineni¹,

Morrow²,

Malesker³

2013

J Prob Health

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“…3,[9][10][11] Pemberian probiotik ini bertujuan untuk mengembalikan komposisi normal mikrobiota usus, sehingga akan mengurangi gejala atopi. [12][13][14][15][16] Sampai saat ini belum diketahui bagaimana pengaruh probiotik terhadap kejadian atopi pada bayi lahir SS yang berasal dari keluarga yang tidak mempunyai riwayat atopi pada 6 bulan pertama kehidupan.…”

Section: Pendahuluanunclassified

“…[5][6][7][8] Sampai saat ini telah diketahui bahwa pemberian probiotik akan mempengaruhi respons imun, yaitu probiotik menimbulkan rangsangan imunomodulasi sistem imun saluran cerna dan juga akan meringankan gejala atopi pada anak yang menderita atopi. 12,13,15 Adanya probiotik pada mukosa dan epitel usus akan membentuk komponen bioaktif yang memproduksi sitokin dan kemokin. Peptidoglikan pada dinding probiotik berfungsi sebagai antigen yang selanjutnya akan terbentuk subset sel T, yaitu Th3 dan sel ini memproduksi TGF-β dan berperan sebagai supresi aktif yang menyebabkan timbulnya toleransi oral.…”

Section: Pembahasanunclassified

Kejadian Atopi pada Bayi Usia 6 Bulan yang Mendapat Kombinasi ASI dan Susu Formula Mengandung Probiotik dan Nonprobiotik

Yuniati¹,

Sukadi²

2011

mkb

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AbstrakKelahiran seksio sesarea menyebabkan terlambatnya kolonisasi flora usus sehingga akan meningkatkan kejadian atopi. Probiotik menstimulasi respons imun sehingga akan menurunkan kejadian atopi. Tujuan penelitian ini untuk menentukan apakah terdapat perbedaan kejadian atopi pada bayi yang diberikan kombinasi ASI dengan susu formula yang mengandung probiotik dan tanpa probiotik. Randomized open label clinical trial dilakukan selama periode November 2009 sampai Oktober 2010 terhadap 96 bayi normal, berat badan lahir ≥2.500 g, lahir dengan seksio sesarea di RS Dr. Hasan Sadikin Bandung. Sejak lahir, selama 4 minggu sebanyak 48 bayi diberikan kombinasi ASI dan susu formula probiotik dan 48 bayi sebagai kontrol, selanjutnya pemberian minuman bergantung pada orangtua. Dilakukan pencatatan lama menyusui, jumlah formula, dan faktor risiko atopi. Skin prick test dilakukan pada usia 6 bulan. Diagnosis atopi ditegakkan jika terbentuk wheal ≥4 mm. Analisis statistik dilakukan dengan chi-square untuk data kategori dan uji t untuk data numerik. Lama menyusui, jumlah formula, dan faktor risiko atopi tidak berbeda secara bermakna pada kedua kelompok (p>0,05). Reaksi atopi ditemukan positif pada 4/23 bayi yang mendapat probiotik dan 10/28 bayi tanpa probiotik (p>0,05). Disimpulkan bahwa kejadian atopi tidak berbeda antara kelompok yang diberikan ASI dan susu formula mengandung probiotik dan tidak mengandung probiotik. [MKB. 2011;43(2):55-9].Kata kunci: Atopi, kelahiran seksio sesarea, probiotik Atopic Occurence on Six-month-old Infants between Probiotic Formula-fed and Non Probiotic Formula-fed Healthy Born by Cesarean Delivery AbstractCesarean delivery might delayed the colonization of newborn intestine and increase atopic disorders. Probiotic shown to stimulate immune responses, which has implied in the development of atopic disorders. The aim of the study was to find out the difference of atopic occurence in breastfed infants born by cesarean delivery given probiotic formula and non probiotic formula. Randomized open label clinical trial was performed on 96 healthy infants, birth weight ≥2,500 g, born by cesarean delivery in Dr. Hasan Sadikin Hospital Bandung during November 2009 to October 2010. Since birth, 48 infants were breastfed combined with probiotic formula and 48 infants as control group for 4 weeks and afterwards the feeding pattern depend on the parents. Skin prick test reaction was performed at 6 months old and atopy was diagnosed if the wheal ≥4 mm. Statistical analysis using chi-square and t-test. The duration of daily breastfeeding, amount of formula and risk factor for atopic disorders were not significantly different in both groups (p>0.05). Atopy were positive in 4/23 infants with probiotic and 10/28 infants positive without probiotic. It was not significantly different (p>0.05). Conclusion, the atopic occurence is not different at 6 months-old receiving breastmilk with probiotic and non probiotic formula. [MKB. 2011;43(2):55-9].

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“…Although no allergy preventive effect was observed in some cohorts, an immune modulatory effect was detected [69]. Reduced TNF and IL-10 responses to house dust mite were found [70]. Boyle et al demonstrated that prenatal Lactobacillus GG supplementation during the last month of pregnancy reduced heat-killed LGG-induced CD4+T cell proliferation [71], although no allergy preventive effects were observed [72].…”

Section: What Are the Mechanisms Behind Probiotics In Allergy Preventmentioning

confidence: 99%

Lactobacillus reuteri, Infant Allergy Prevention and Childhood Immune Maturation

Forsberg¹

2016

Probiotics and Prebiotics in Human Nutrition and Health

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The increasing allergy prevalence in affluent countries may be caused by reduced microbial stimulation, resulting in an abnormal postnatal immune maturation. This chapter concerns the theories behind the use of probiotics in randomized prevention trials, and how this supplementation affects the immunity of pregnant women, the immune development in their children, and possibly preventing allergic diseases. Most studies investigating the underlying mechanisms have focused on postnatal microbial exposure. An increasing body of evidence from studies suggests that the maternal microbial environment during pregnancy can program the immune development of the child. In human allergy intervention studies, probiotic supplementation to the mother during pregnancy, as well as to her baby postnatally, may be important for preventive effects. Also, prenatal environmental exposures may alter gene expression via epigenetic mechanisms, aiming to induce physiological adaptations to the anticipated postnatal environment. The maternal microbial environment during pregnancy may program the immune development of the child.

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Effects of probiotic supplementation for the first 6 months of life on allergen‐ and vaccine‐specific immune responses

Abstract: In summary, although we did not see any consistent effects on allergen-specific responses, our study suggests that probiotics may have immunomodulatory effects on vaccine responses. The significance and clinical relevance of this need to be determined in further studies.

Cited by 67 publications

References 36 publications

Probiotics: Mechanisms of Action and Clinical Applications

Probiotics: Mechanisms of Action and Clinical Applications

Kejadian Atopi pada Bayi Usia 6 Bulan yang Mendapat Kombinasi ASI dan Susu Formula Mengandung Probiotik dan Nonprobiotik

Lactobacillus reuteri, Infant Allergy Prevention and Childhood Immune Maturation

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