Effects of Probiotic Supplementation on Oxidative Stress Indices in Women with Rheumatoid Arthritis: A Randomized Double-Blind Clinical Trial

Vaghef-Mehrabany, Elnaz; Rad, Aziz Homayouni; Alipour, Beitullah; Sharif, Sakineh-Khatoun; Vaghef-Mehrabany, Leila; Alipour-Ajiry, Serour

doi:10.1080/07315724.2014.959208

Cited by 70 publications

(57 citation statements)

References 42 publications

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“…For example, it was reported that 6 weeks probiotic treatment caused no significant change in inflammatory factors of diabetic patients (Mazloom et al, 2013). Furthermore, 8 weeks consumption of capsules containing 10 8 CFU/g of L. casei by the people suffered from rheumatoid arthritis displayed no significant within- and between-group changes in MDA and TAC levels (Vaghef-Mehrabany et al, 2015). Oxidative stress is a frequently observed feature of AD, although its pathological significance is not understood (Selvarajah et al, 2011).…”

Section: Discussionmentioning

confidence: 99%

Effect of Probiotic Supplementation on Cognitive Function and Metabolic Status in Alzheimer's Disease: A Randomized, Double-Blind and Controlled Trial

Akbari

Asemi

Kakhaki

et al. 2016

Front. Aging Neurosci.

715

435

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Alzheimer's disease (AD) is associated with severe cognitive impairments as well as some metabolic defects. Scant studies in animal models indicate a link between probiotics and cognitive function. This randomized, double-blind, and controlled clinical trial was conducted among 60 AD patients to assess the effects of probiotic supplementation on cognitive function and metabolic status. The patients were randomly divided into two groups (n = 30 in each group) treating with either milk (control group) or a mixture of probiotics (probiotic group). The probiotic supplemented group took 200 ml/day probiotic milk containing Lactobacillus acidophilus, Lactobacillus casei, Bifidobacterium bifidum, and Lactobacillus fermentum (2 × 109 CFU/g for each) for 12 weeks. Mini-mental state examination (MMSE) score was recorded in all subjects before and after the treatment. Pre- and post-treatment fasting blood samples were obtained to determine the related markers. After 12 weeks intervention, compared with the control group (−5.03% ± 3.00), the probiotic treated (+27.90% ± 8.07) patients showed a significant improvement in the MMSE score (P <0.001). In addition, changes in plasma malondialdehyde (−22.01% ± 4.84 vs. +2.67% ± 3.86 μmol/L, P <0.001), serum high-sensitivity C-reactive protein (−17.61% ± 3.70 vs. +45.26% ± 3.50 μg/mL, P <0.001), homeostasis model of assessment-estimated insulin resistance (+28.84% ± 13.34 vs. +76.95% ± 24.60, P = 0.002), Beta cell function (+3.45% ± 10.91 vs. +75.62% ± 23.18, P = 0.001), serum triglycerides (−20.29% ± 4.49 vs. −0.16% ± 5.24 mg/dL, P = 0.003), and quantitative insulin sensitivity check index (−1.83 ± 1.26 vs. −4.66 ± 1.70, P = 0.006) in the probiotic group were significantly varied compared to the control group. We found that the probiotic treatment had no considerable effect on other biomarkers of oxidative stress and inflammation, fasting plasma glucose, and other lipid profiles. Overall, the current study demonstrated that probiotic consumption for 12 weeks positively affects cognitive function and some metabolic statuses in the AD patients. Clinical Trial Registration: http://www.irct.ir/, IRCT201511305623N60.

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Section: Discussionmentioning

confidence: 99%

Effect of Probiotic Supplementation on Cognitive Function and Metabolic Status in Alzheimer's Disease: A Randomized, Double-Blind and Controlled Trial

Akbari

Asemi

Kakhaki

et al. 2016

Front. Aging Neurosci.

715

435

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“…10,12,27 In the study by Pineda et al 27 in which no significant effect of probiotic supplementation (only Lactobacillus reuteri) on inflammatory cytokines was found compared with the placebo group, only the Health Assessment Questionnaire (HAQ) and inflammatory cytokines were examined and the effect of sup-plementation was not assessed on markers of insulin resistance, lipid profiles or biomarkers of oxidative stress. We found that taking probiotic supplements for 8 weeks in patients with RA resulted in improved DAS-28, decreased levels of serum insulin, HOMA-B and hs-CRP levels compared with the placebo, but did not detect influences on FPG, HOMA-IR, QUICKI, lipid profiles, plasma NO and biomarkers of oxidative stress.…”

Section: Discussionmentioning

confidence: 99%

“…Furthermore, adjunctive treatment with Bacillus coagulans GBI-30 for 60 days among patients with RA resulted in a significant decrease in CRP levels. 12 We have previously assessed the effect of probiotics on biomarkers of oxidative stress in patients with T2DM and MDD. 14 However, some researchers did not observe such beneficial effects of probiotic supplementation on inflammatory markers.…”

Section: Discussionmentioning

confidence: 99%

“…bulgaricus decreased the clinical severity in arthritic changes. 12 Probiotic intake may improve clinical and metabolic status in RA patients through its anti-inflammatory effects both locally in the gut and systemically, 13,14 through increased production of bacteriocins 15 and short chain fatty acids (SCFA) such as butyric acid, 16 down-regulating inflammation and blocking suppression of glucose transporter type 4. 9 However, few studies have assessed the effect of probiotics supplementation on Disease Activity Score of 28 joints (DAS-28), biomarkers of inflammation and oxidative stress, and also results are conflicting.…”

Section: Introductionmentioning

confidence: 99%

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Expression of Concern: Clinical and metabolic response to probiotic supplementation in patients with rheumatoid arthritis: a randomized, double‐blind, placebo‐controlled trial

et al. 2016

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“…However, while one uncontrolled study of probiotics included in this review showed an improvement in BASDAI and VAS scores, two RCTs did not confirm this association (28,30,36). Several small trials of probiotics in RA patients have reported marginal, non-significant, beneficial effects on the RA disease activity (59)(60)(61).…”

Section: Discussionmentioning

confidence: 97%

Relationship between diet and ankylosing spondylitis: A systematic review

Macfarlane¹,

Abbood²,

Pathan³

et al. 2018

Eur J Rheumatol

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The question of whether diet plays a role in the onset of ankylosing spondylitis (AS) or can affect the course of the disease is an important one for many patients and healthcare providers. The aims of this study were to investigate whether: 1) patients with AS report different diets to those without AS; 2) amongst patients with AS, diet is related to severity; 3) persons with particular diets are less likely to develop AS; 4) specific dietary interventions improve the AS symptoms. The review was conducted according to the Preferred Reporting Items for Systematic Reviews and Meta-Analyses (PRISMA) guidelines. Medline, Embase, Cochrane Library, and reference lists of relevant articles were searched. Two authors independently selected eligible studies, assessed the quality of included trials, and extracted the data. Sixteen studies (nine observational and seven interventions) were included in the review. Due to the heterogeneity of the study designs and analyses, the results could not be aggregated. Evidence on a possible relationship between AS and diet is extremely limited and inconclusive due to the majority of included studies being small, single studies with moderate-to-high risk of bias, and insufficient reporting of results.

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Effects of Probiotic Supplementation on Oxidative Stress Indices in Women with Rheumatoid Arthritis: A Randomized Double-Blind Clinical Trial

Abstract: No significant effect of L. casei 01 supplementation was observed on the oxidative status of patients with RA, compared to placebo.

Cited by 70 publications

References 42 publications

Effect of Probiotic Supplementation on Cognitive Function and Metabolic Status in Alzheimer's Disease: A Randomized, Double-Blind and Controlled Trial

Effect of Probiotic Supplementation on Cognitive Function and Metabolic Status in Alzheimer's Disease: A Randomized, Double-Blind and Controlled Trial

Expression of Concern: Clinical and metabolic response to probiotic supplementation in patients with rheumatoid arthritis: a randomized, double‐blind, placebo‐controlled trial

Relationship between diet and ankylosing spondylitis: A systematic review

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