Effects of probiotic supplements on the progression of chronic kidney disease: A meta‐analysis

Tao, Sibei; Shi, Tao; Cheng, Yiming; Liu, Jing; Ma, Liang; Fu, Ping

doi:10.1111/nep.13549

Cited by 31 publications

(23 citation statements)

References 48 publications

(141 reference statements)

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“…Similarly, another RCT-based meta-analysis of probiotics in CKD control revealed more promising results to manage urea levels in non-dialysis CKD patients. On the other hand, no significant change in glomerular filtration rate, uric acid, serum creatinine, and C-reactive protein concentrations were found ( Tao et al, 2019 ).…”

Section: Health-boosting Spectrum Of Probioticsmentioning

confidence: 99%

Therapeutic, Prophylactic, and Functional Use of Probiotics: A Current Perspective

2020

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Probiotics are considered as the twenty-first century panpharmacon due to their competent remedial power to cure from gastrointestinal dysbiosis, systematic metabolic diseases, and genetic impairments up to complicated neurodegenerative disorders. They paved the way for an innovative managing of various severe diseases through palatable food products. The probiotics’ role as a “bio-therapy” increased their significance in food and medicine due to many competitive advantages over traditional treatment therapies. Their prophylactic and therapeutic potential has been assessed through hundreds of preclinical and clinical studies. In addition, the food industry employs probiotics as functional and nutraceutical ingredients to enhance the added value of food product in terms of increased health benefits. However, regardless of promising health-boosting effects, the probiotics’ efficacy still needs an in-depth understanding of systematic mechanisms and factors supporting the healthy actions.

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Section: Health-boosting Spectrum Of Probioticsmentioning

confidence: 99%

Therapeutic, Prophylactic, and Functional Use of Probiotics: A Current Perspective

2020

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“…The age-standardized global prevalence of CKD in adults aged 20 and older was 10.4% in men and 11.8% in women [18]. This disease, which is considered a public health problem [19], results in sufferers having to use renal replacement therapy to substitute the renal function. There are currently two dialytic techniques available: hemodialysis and peritoneal dialysis [20].…”

Section: Introductionmentioning

confidence: 99%

Quality of Life and Social Support of People on Peritoneal Dialysis: Mixed Methods Research

Sitjar-Suñer

Soler

Masià-Plana

et al. 2020

IJERPH

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Although some study has been made into quality of life in patients with peritoneal dialysis, little is known about how this relates to social support. The aim of this paper was to study health-related quality of life, perceived social support and the experiences of people receiving peritoneal dialysis. A cross-sectional study was conducted using quantitative and qualitative methodologies, between June 2015 and March 2017. Fifty-five patients receiving peritoneal dialysis were studied. The most affected quality of life dimensions were the effects of the disease, the burden of the disease, occupational status, sleep and satisfaction. The physical component of the quality of life questionnaire was negatively associated with the number of hospital admissions over the previous year (p = 0.027) and positively associated with social support (p = 0.002). With regard to the mental component, age (p = 0.010) and social support (p = 0.041) were associated with a better quality of life. Peritoneal dialysis, while not a panacea, is experienced as being less aggressive than hemodialysis, allowing greater autonomy and improved perceived health. Greater symptomology corresponded to worse quality of life and to perceiving the disease as a burden. Patients had to adapt to the new situation despite their expectations. Social support was observed to be a key factor in perceived quality of life.

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“…Wang et al [85] reported that supplementation with Lactobacillus DM9218 decreases serum uric acid in fructose-fed mice; the authors suggested that it may protect against high-fructose-induced liver damage and retinol uric acid accumulation by degrading inosine. The uric acid level was also significantly reduced in non-dialysis patients with CKD who received probiotics [86]. Moreover, the eight-week consumption of L. gasseri PA-3 yoghurt was found to decrease the level of serum uric acid in 25 patients [87].…”

Section: The Effects Of Probiotics Prebiotics and Synbiotics On Uric Acid Levelsmentioning

confidence: 91%

Probiotics, Prebiotics and Synbiotics—A Promising Strategy in Prevention and Treatment of Cardiovascular Diseases?

Olas

2020

IJMS

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Recent evidence suggests that probiotics, prebiotics and synbiotics may serve as important dietary components in the prevention (especially) and treatment of cardiovascular diseases (CVD), but the recommendations for their use are often based on brief reports and small clinical studies. This review evaluates the current literature on the correlation between CVD and probiotics, prebiotics and synbiotics. Although research on probiotics, prebiotics and synbiotics has grown exponentially in recent years, particularly regarding the effect of probiotics on CVD, their mechanisms have not been clearly defined. It has been proposed that probiotics lower cholesterol levels, and may protect against CVD, by increasing bile salt synthesis and bile acid deconjugation. Similar effects have also been observed for prebiotics and synbiotics; however, probiotics also appear to have anti-oxidative, anti-platelet and anti-inflammatory properties. Importantly, probiotics not only have demonstrated effects in vitro and in animal models, but also in humans, where supplementation with probiotics decreases the risk factors of CVD. In addition, the properties of commercial probiotics, prebiotics and synbiotics remain undetermined, and further experimental research is needed before these substances can be used in the prevention and treatment of CVD. In particular, well-designed clinical trials are required to determine the influence of probiotics on trimethylamine-N-oxide (TMAO), which is believed to be a marker of CVDs, and to clarify the long-term effects, and action, of probiotic, prebiotic and synbiotic supplementation in combination with drug therapy (for example, aspirin). However, while it cannot be unequivocally stated whether such supplementation yields benefits in the prevention and treatment of CVDs, it is important to note that clinical studies performed to date have not identified any side-effects to use.

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Effects of probiotic supplements on the progression of chronic kidney disease: A meta‐analysis

Cited by 31 publications

References 48 publications

Therapeutic, Prophylactic, and Functional Use of Probiotics: A Current Perspective

Therapeutic, Prophylactic, and Functional Use of Probiotics: A Current Perspective

Quality of Life and Social Support of People on Peritoneal Dialysis: Mixed Methods Research

Probiotics, Prebiotics and Synbiotics—A Promising Strategy in Prevention and Treatment of Cardiovascular Diseases?

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