Effects of probiotics on the improvement and regulation of intestinal barrier dysfunction and immune imbalance in intra‑abdominal infections (Review)

Tang, Shuangfeng; Liu, Jiayue; Xu, Caiming; Shang, Dong; Chen, Hailong; Zhang, Guixin

doi:10.3892/ijfn.2021.22

Cited by 5 publications

(2 citation statements)

References 78 publications

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“…In fact, the study by Velasco et al showed mice undergoing fecal microbiota transplantation being less prone to surgical site infections [53]. On the other hand, probiotics products (e.g., the extracellular polysaccharide EPScG11 of Lactobacillus plantarum that reduces the expression of pro-inflammatory factors and increases the expression of anti-inflammatory factors in rats) could be used as a treatment for intra-abdominal infections [54].…”

Section: Infective Complications After Liver Transplantationmentioning

confidence: 99%

Gut Microbiota and Liver Transplantation: Immune Mechanisms behind the Rejection

et al. 2023

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Liver transplantation (LT) is the treatment of choice for patients with cirrhosis, decompensated disease, acute liver failure, and hepatocellular carcinoma (HCC). In 3–25% of cases, an alarming problem is acute and chronic cellular rejection after LT, and this event can lead to the need for new transplantation or the death of the patient. On the other hand, gut microbiota is involved in several mechanisms sustaining the model of the “gut–liver axis”. These include modulation of the immune response, which is altered in case of gut dysbiosis, possibly resulting in acute graft rejection. Some studies have evaluated the composition of the gut microbiota in cirrhotic patients before and after LT, but few of them have assessed its impact on liver rejection. This review underlines the changes in gut microbiota composition before and after liver transplantation, hypothesizing possible immune mechanisms linking dysbiosis to transplantation rejection. Evaluation of changes in the gut microbiota composition in these patients is therefore essential in order to monitor the success of LT and eventually adopt appropriate preventive measures.

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Section: Infective Complications After Liver Transplantationmentioning

confidence: 99%

Gut Microbiota and Liver Transplantation: Immune Mechanisms behind the Rejection

et al. 2023

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“…One of the most actively studied sources of anti-obesity efficiency is probiotics [ 7 , 8 ]. Probiotics have been proposed as an anti-obesity agent through several molecular mechanisms, including metabolic changes [ 9 , 10 ], improvement of the intestinal barrier, modulating the immune response [ 11 ], reduced adipocyte size [ 10 ], and decreasing dietary fat absorption [ 12 ]. Supplementation of probiotics to high-fat diet-induced obese mice alleviates body weight gain and adiposity by modulating the composition of the gut-associated microbiota.…”

Section: Introductionmentioning

confidence: 99%

A Transcriptomic Response to Lactiplantibacillus plantarum-KCC48 against High-Fat Diet-Induced Fatty Liver Diseases in Mice

Ilavenil

Muthusamy

Jung

et al. 2022

IJMS

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The most prevalent chronic liver disorder in the world is fatty liver disease caused by a high-fat diet. We examined the effects of Lactiplantibacillus plantarum-KCC48 on high-fat diet-induced (HFD) fatty liver disease in mice. We used the transcriptome tool to perform a systematic evaluation of hepatic mRNA transcripts changes in high-fat diet (HFD)-fed animals and high-fat diet with L. plantarum (HFLPD)-fed animals. HFD causes fatty liver diseases in animals, as evidenced by an increase in TG content in liver tissues compared to control animals. Based on transcriptome data, 145 differentially expressed genes (DEGs) were identified in the liver of HFD-fed mice compared to control mice. Moreover, 61 genes were differentially expressed in the liver of mice fed the HFLPD compared to mice fed the HFD. Additionally, 43 common DEGs were identified between HFD and HFLPD. These genes were enriched in metabolic processes, retinol metabolism, the PPAR signaling pathway, fatty acid degradation, arachidonic metabolism, and steroid hormone synthesis. Taking these data into consideration, it can be concluded that L. plantarum-KCC48 treatment significantly regulates the expression of genes involved in hepatosteatosis caused by HFD, which may prevent fatty liver disease.

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Relationship between gut microbiota and colorectal cancer: Probiotics as a potential strategy for prevention

Lee

Kang

et al. 2022

Food Research International

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Effects of probiotics on the improvement and regulation of intestinal barrier dysfunction and immune imbalance in intra‑abdominal infections (Review)

Cited by 5 publications

References 78 publications

Gut Microbiota and Liver Transplantation: Immune Mechanisms behind the Rejection

Gut Microbiota and Liver Transplantation: Immune Mechanisms behind the Rejection

A Transcriptomic Response to Lactiplantibacillus plantarum-KCC48 against High-Fat Diet-Induced Fatty Liver Diseases in Mice

Relationship between gut microbiota and colorectal cancer: Probiotics as a potential strategy for prevention

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