Effects of probiotics supplementation on blood pressure: An umbrella meta-analysis of randomized controlled trials

Zarezadeh, Meysam; Musazadeh, Vali; Ghalichi, Faezeh; Kavyani, Zeynab; Nasernia, Romina; Parang, Maryam; Jamilian, Parmida; Jamilian, Parsa; Fakhr, Laleh; Ostadrahimi, Alireza; Mekary, Rania A.

doi:10.1016/j.numecd.2022.09.005

Cited by 15 publications

(6 citation statements)

References 54 publications

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“…The addition of L. kefiri to a low-calorie diet increased weight loss and further improved the glycemic and lipid profile and also caused a further improvement in obesity-associated dysbiosis, mainly by increasing the muconutritive and regulatory (e.g., Bifidobacterium spp., Akkermansia muciniphila) microbiome, and decreasing the Firmicutes/Bacteroidetes ratio (Ruiz-Tovar et al, 2023). In addition, recent studies demonstrated that chronic consumption of probiotics, oats, soymilk, and apples may decrease diastolic blood pressure, triglycerides, total cholesterol, and insulin levels and significantly increase high-density lipoprotein cholesterol, beneficially affecting cardiometabolic health (Naseri et al, 2022;Pavlidou et al, 2022;Hasanpour et al, 2023;Pushpass et al, 2023;Zarezadeh et al, 2023). A cross-sectional study involving a group of 190 schoolchildren from public schools in Brazil aimed to evaluate the fecal abundance of Bifidobacterium spp.…”

Section: Probiotics In Cardiovascular and Cerebrovascular Diseasesmentioning

confidence: 99%

Role of probiotics in managing various human diseases, from oral pathology to cancer and gastrointestinal diseases

Petrariu,

Barbu,

Niculescu

et al. 2024

Front. Microbiol.

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The imbalance of microbial composition and diversity in favor of pathogenic microorganisms combined with a loss of beneficial gut microbiota taxa results from factors such as age, diet, antimicrobial administration for different infections, other underlying medical conditions, etc. Probiotics are known for their capacity to improve health by stimulating the indigenous gut microbiota, enhancing host immunity resistance to infection, helping digestion, and carrying out various other functions. Concurrently, the metabolites produced by these microorganisms, termed postbiotics, which include compounds like bacteriocins, lactic acid, and hydrogen peroxide, contribute to inhibiting a wide range of pathogenic bacteria. This review presents an update on using probiotics in managing and treating various human diseases, including complications that may emerge during or after a COVID-19 infection.

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Section: Probiotics In Cardiovascular and Cerebrovascular Diseasesmentioning

confidence: 99%

Role of probiotics in managing various human diseases, from oral pathology to cancer and gastrointestinal diseases

Petrariu,

Barbu,

Niculescu

et al. 2024

Front. Microbiol.

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“…Recent studies have also highlighted the potential of probiotics as adjuncts to traditional weight loss interventions, yielding reductions in weight and BMI 31 , 32 . Furthermore, through their anti-hypertensive effects by modulating gut microbiota and balancing various factors that regulate the renin-angiotensin system 33 , probiotic supplementations have led to significant blood pressure reduction in healthy, obese, diabetic, and even hypertensive patients 34 , 35 . Gut dysbiosis is linked to microbial translocation and the development of chronic inflammation in CAD through multiple mechanisms, one of them being metabolic endotoxemia which exacerbates the formation of atherosclerotic plaques 36 .…”

Section: Probiotics and Their Potential Effects On Cardiovascular Dis...mentioning

confidence: 99%

Unlocking the gut-heart axis: exploring the role of gut microbiota in cardiovascular health and disease

Shariff,

Kwan Su Huey,

Parag Soni

et al. 2024

Annals of Medicine &Amp; Surgery

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Introduction: Gut microbiota has emerged as a pivotal player in cardiovascular health and disease, extending its influence beyond the gut through intricate metabolic processes and interactions with the immune system. Accumulating evidence supports a significant association between gut microbiota and cardiovascular diseases such as atherosclerosis, hypertension, and heart failure. Dietary patterns have been identified as key factors shaping the composition of the gut microbiota and exerting notable impacts on cardiovascular health. Probiotics and prebiotics have shown promise in mitigating the risks of cardiovascular disease by modulating key cardiovascular parameters. Fecal microbiota transplantation (FMT) has recently emerged as a novel and intriguing therapeutic strategy. Aim: This review paper aims to explore and elucidate the multifaceted role of gut microbiota in cardiovascular health. It will also address the prevailing challenges and limitations in gut microbiota studies, emphasizing the importance of future research in overcoming these obstacles to expand our understanding of the gut-heart axis. Materials and methods: A comprehensive literature search was conducted using various databases including ClinicalTrials, Google Scholar, PubMed, ScienceDirect, MEDLINE, and Ovid Resources. The search strategy included utilizing keywords such as “Gut microbiota,” “Randomized controlled trials (RCTs),” “Gut-heart axis,” “Dysbiosis,” “Diet,” “Probiotics,” “Prebiotics,” “Fecal Microbiota transplantation,” “cardiovascular disease,” “Meta-analyses,” and other compatible terms thereof. Only articles written in English were considered, and selection criteria included relevance to the research objectives, reasonable sample sizes, and robust methodology. In addition to the identified articles, meta-analyses, animal models and studies, and references from the selected articles were also examined to ensure a comprehensive review of the literature. Results: Dietary patterns exert a significant influence on the composition of the gut microbiota, and certain diets, such as the Mediterranean diet, have been associated with a favorable gut microbiota profile and a reduced risk of cardiovascular disease (CVD). Probiotics and prebiotics have emerged as potential interventions to mitigate CVD risks by modulating blood pressure, glycemic control, lipid profiles, and gut dysbiosis. Another innovative therapeutic approach is fecal microbiota transplantation (FMT), which involves transferring fecal material from a healthy donor to restore a balanced gut microbiota. FMT holds promise for improving cardiometabolic parameters in individuals with CVD, although further research is needed to elucidate its precise mechanisms and assess its effectiveness. Conclusion: The gut microbiota is emerging as a potential therapeutic target for CVD prevention and management. However, current research has limitations, including the need for larger and more diverse studies, the challenges of establishing causality, and concerns regarding the long-term consequences and safety of gut microbiota modulation. Despite these limitations, understanding the gut-heart axis holds promise for the development of personalized therapies and interventions for cardiovascular health. Further research is needed to expand our knowledge and address the ethical and safety issues associated with gut microbiota modification.

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“…The study also suggested that the antidepressant effect was more relevant when using high doses of probiotics and for at least 8 weeks. Considering that probiotic treatment is usually well tolerated, and beneficial also on metabolic disorders [ 89 - 91 ], it may be useful to use it more in routine clinical practice while awaiting further studies. In fact, it is not yet fully understood which exact composition should be administered, given the high number and complexity of bacterial species present in the gut.…”

Section: Microbiotamentioning

confidence: 99%

A Critical View on New and Future Antidepressants

Serretti

2024

Clin Psychopharmacol Neurosci

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For the first time after many decades, many new antidepressants have been approved and many more are under various stages of development and will soon be available in the market. The new drugs present a range of new mechanisms of action with benefits in terms of speed of action, tolerability and range of treatable disorders. Neurosteroids have been recently approved and their rapid benefit may extend from postpartum depression to anxious depression and bipolar depression, dextromethorphan and bupropion combination may prove useful in major depression but also in treatment resistant depression, dextromethadone is a possible augmentation in partial antidepressant response, psychedelic drugs have the potential of long lasting benefits after a single administration, though are still experimental treatments. Botulinum has the same advantage of psychedelics of a single administration and its antidepressant effects may last for weeks or more. Further potentially interesting new antidepressant mechanisms include new drug targets, drug repurposing and genetic or epigenetic manipulations. It is therefore important that clinicians are kept up to date with new evidence so that new evidence can be rapidly translated into clinical practice.

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Effects of probiotics supplementation on blood pressure: An umbrella meta-analysis of randomized controlled trials

Cited by 15 publications

References 54 publications

Role of probiotics in managing various human diseases, from oral pathology to cancer and gastrointestinal diseases

Role of probiotics in managing various human diseases, from oral pathology to cancer and gastrointestinal diseases

Unlocking the gut-heart axis: exploring the role of gut microbiota in cardiovascular health and disease

A Critical View on New and Future Antidepressants

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