2019
DOI: 10.1016/j.lfs.2019.116979
|View full text |Cite
|
Sign up to set email alerts
|

Effects of progesterone on glucose uptake in neurons of Alzheimer's disease animals and cell models

Help me understand this report

Search citation statements

Order By: Relevance

Paper Sections

Select...
3
2

Citation Types

0
26
0

Year Published

2020
2020
2023
2023

Publication Types

Select...
8
2

Relationship

0
10

Authors

Journals

citations
Cited by 31 publications
(26 citation statements)
references
References 61 publications
0
26
0
Order By: Relevance
“…Sabbir [25] recently reported that PGRMC1 induced a P4-dependent metabolic change resembling the Warburg effect in HEK293 cells, which was associated with changes in PGRMC1 stability, posttranslational modifications, and subcellular locations. PGRMC1 regulation of glucose metabolism is supported by its implicated mediation of the placental P4dependent shift from aerobic towards anaerobic glucose metabolism in gestational diabetes [26], association with the insulin receptor and glucose transporters [27], and probable involvement (based upon AG-205 sensitivity) in P4-mediated increase in neuronal glycolysis [28].…”
Section: Introductionmentioning
confidence: 99%
“…Sabbir [25] recently reported that PGRMC1 induced a P4-dependent metabolic change resembling the Warburg effect in HEK293 cells, which was associated with changes in PGRMC1 stability, posttranslational modifications, and subcellular locations. PGRMC1 regulation of glucose metabolism is supported by its implicated mediation of the placental P4dependent shift from aerobic towards anaerobic glucose metabolism in gestational diabetes [26], association with the insulin receptor and glucose transporters [27], and probable involvement (based upon AG-205 sensitivity) in P4-mediated increase in neuronal glycolysis [28].…”
Section: Introductionmentioning
confidence: 99%
“…For detailed investigation of AD formation, various in vivo and in vitro experiments have been performed (Wu et al, 2019) in order to follow the molecular biological alterations. There are a few genetically modified mice with tau and Aβ overexpression showing macroscopical and molecular biological disorders of AD (Radak et al, 2010;Abraham et al, 2019).…”
Section: Introductionmentioning
confidence: 99%
“…However, we have shown previously that necrosis, autophagy, apoptosis, and ferroptosis are involved in neuronal death in the acute period after ICH 31 , 43 . Therefore, even though investigators have reported that higher neuronal GLUT3 benefits neuronal function and learning in Alzheimer’s disease 44 46 , it seems less likely in our study. Neuronal death in the ipsilateral striatum certainly contributed to the glucose hypometabolism detected in 18 F-FDG-PET imaging.…”
Section: Discussionmentioning
confidence: 58%