Effects of progesterone on prolactin secretion in hypogonadal women.

Minakami, Hisanori; Kimura, Kozo; Ijima, Kunihiko; Tamada, Taro

doi:10.1507/endocrj1954.32.645

Cited by 1 publication

(4 citation statements)

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“…Twelve female subjects received 50 mg of progesterone intramuscularly and their blood samples were monitored every 15 min for prolactin levels. Eight of the 12 subjects (66.7%) had lower prolactin levels, indicating that progesterone suppresses estrogen-induced prolactin secretion [21] .…”

Section: Resultsmentioning

confidence: 97%

“…This could explain the observed genderrelated differences in immune responses [19] . Pregnant women are at increased risk of toxoplasmosis-induced abortion and stillbirths, especially during the second and third quarters of gestation [20][21] . Interestingly, the prevalence of toxoplasmosis has been positively correlated with progesterone and negatively correlated with prolactin levels [21][22] .…”

Section: Resultsmentioning

confidence: 99%

“…Pregnant women are at increased risk of toxoplasmosis-induced abortion and stillbirths, especially during the second and third quarters of gestation [20][21] . Interestingly, the prevalence of toxoplasmosis has been positively correlated with progesterone and negatively correlated with prolactin levels [21][22] . This suggests that progesterone and prolactin levels determine the reproduction and survival of T.gondii in pregnant women.…”

Section: Resultsmentioning

confidence: 99%

“…Apart from their primary function of promoting mammary tissue growth [24] , estrogen and progesterone have marked effects on the secretion of other sex hormones, especially gonadotrophins, and prolactin. A previous experimental study by Minakami et al (1985) tested the hypothesis that progesterone is involved in the regulation of estrogen-induced prolactin release in hypogonadal women. Twelve female subjects received 50 mg of progesterone intramuscularly and their blood samples were monitored every 15 min for prolactin levels.…”

Section: Resultsmentioning

confidence: 99%

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The Relationship Between Toxoplasmosis and Concentration of Prolactin and Progesterone in Pregnant Women

Alshammary,

Alanazi,

Alghamdi

et al. 2024

ijirms

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Toxoplasma gondii (T.gondii) is an intracellular protozoon that causes toxoplasmosis in one-third of the world's population. During pregnancy, the prevalence of toxoplasmosis rises during the second and third trimesters causing abortion and a mild mononucleosis-like syndrome. Normally, progesterone rises during pregnancy, but in the case of toxoplasmosis, the body raises prolactin to inhibit T. gondii. The present study investigated the relationship between Toxoplasma gondii infection (toxoplasmosis) and the concentration of both prolactin and progesterone in infected pregnant women. A systematic review approach was conducted to research the aim of this study. PubMed, Scopus, Web of Science, and Google Scholar were searched using the following keywords “Toxoplasma gondii” or “T.gondii” AND “protozoon” OR “toxoplasmosis” OR “animals” OR “prolactin” OR “progesterone.” Only primary studies were included, whereas reviews and non-experimental studies were excluded. Six studies met the inclusion criteria and were, therefore, reviewed in the present study. The six studies showed a reverse relationship between prolactin and progesterone, such that if one increases the other drops. Furthermore, Toxoplasmosis increased progesterone levels, which results in the suppression of prolactin levels. Thus, toxoplasmosis-induced progesterone secretion has an antagonistic effect on prolactin levels. Since prolactin strongly elicits innate and adaptive immune responses, toxoplasmosis-induced progesterone release dampens the immune response of the host and enhances susceptibility to severe toxoplasmosis.

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Section: Resultsmentioning

confidence: 97%