Effects of progesterone on the ocular hypertensive response to prostaglandin

Chiang, Tzu Sung; Thomas, Robert Paul

doi:10.1016/0014-2999(73)90030-7

Cited by 10 publications

(4 citation statements)

References 15 publications

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“…This is not consistent with the hypothesis of Chiang & Thomas (1972) that the release (or injection, as in their experiments) of prostaglandins into the anterior chamber of one eye leads to consensual pressure changes in the contralateral eye, supposedly by way of prostaglandins released into the circulation. This may be explicable, however, on the grounds of type and dosage of drugs that were used in their injection experiments.…”

contrasting

confidence: 95%

Meiosis: A Prostaglandin Response That Is Not Inhibited by Aspirin

Dellow¹,

Miles²

1975

British J Pharmacology

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contrasting

confidence: 95%

Meiosis: A Prostaglandin Response That Is Not Inhibited by Aspirin

Dellow¹,

Miles²

1975

British J Pharmacology

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“…Consesual reactions during different kinds of ocular inflammatory .states have been observed by several authors (Davson & Quilliam 1947;Davson & Machette 1951;Perkins 1957;Beitch & Eakins 1969;Chiang & Thomas 1972;Kottow & Seligman 1978). However, the mechanism of this contralateral transmission is unclear.…”

Section: Discussionmentioning

confidence: 85%

An Acute Ocular Inflammatory Reaction Induced by Intravitreal Bovine Serum Albumin in Presensitized Rabbits: The Effect of Phentolamine

Uusitalo

1984

Acta Ophthalmologica

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An acute inflammatory reaction in the uvea was challenged by an intravitreal injection of bovine serum albumin (BSA) in presensitized rabbits. During the observation time of 3 h, intraocular pressure (IOP) increased, anterior uveal blood vessels were dilated, miosis was produced, and as a sign of the breakdown of the blood aqueous barrier, protein content in the aqueous humour was increased. In the contralateral eye, the reaction consisted of an increase in IOP and a disruption of the blood aqueous barrier. As an evidence of the immunological mechanism of this acute reaction, presensitized animals intravitreally injected with saline or unimmunized rabbits which were injected with BSA showed no significant changes in IOP, pupillary diameter or protein content in aqueous humour. Phentolamine significantly reduced protein leakage into the anterior chamber of the experimental eye. It also significantly inhibited the increase in IOP and protein leakage in the contralateral eye. The present findings demonstrate that a hypertensive inflammatory phase is present in the acute experimental uveitis. The mechanisms of the reaction and the mode of action of phentolamine are discussed.

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“…The rapid rise of PGE2 levels in the aqueous humor of contralateral eyes follow ing paracentesis in the ipsilateral eyes is comparable to the consensual ocular re sponse after intracameral injection of PG [17], This consensual reaction can be ex plained by either a release of PGE2 in the contralateral eye resulting from an antidromal reflex via the trigeminal nerve [18] or the transfer of PGE2 from the punctured to the contralateral eye via the blood circula tion [19], From our results, there is no evidence for a release of PGE2 into the vitreous of the eye after indentation or laser photocoagulation. PGE2, released after paracentesis of the ante rior chamber, is not transported by diffusion through the vitreous body to the posterior segment as postulated by Yanuzzi [4] for the occurrence of CME after lens extraction and my Miyake [1] for CME in phakic eyes.…”

Section: <= Hmentioning

confidence: 66%

Prostaglandin E₂in the Vitreous Body of the Normal Rabbit Eye and after Ocular Trauma

et al. 1991

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Rabbit eyes were enucleated and frozen in liquid nitrogen. The vitreous was removed and analyzed for prostaglandin E₂ (PGE₂). The mean level ( ± SEM) of PGE₂ in the anterior as well as in the posterior vitreous was 0.09 ± 0.016 ng/ml (n = 12 rabbits). Animals pretreated with indomethacin 15 min before death, in order to prevent the formation of prostaglandin during enucleation, showed in both the anterior and posterior vitreous mean PGE₂ levels of 0.04 ± 0.008 ng/ml (n = 12) which were significantly lower. Ocular trauma such as paracentesis of the anterior chamber, indentation of the sclera or laser photocoagulation in the fundus 1 h before death of the animals did not increase the concentration of PGE₂ in the vitreous humor. There is no evidence either for local release of PGE₂ from tissues in the fundus of the eye or for diffusion of PGE₂ from the anterior chamber into the vitreous humor.

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Effects of progesterone on the ocular hypertensive response to prostaglandin

Cited by 10 publications

References 15 publications

Meiosis: A Prostaglandin Response That Is Not Inhibited by Aspirin

Meiosis: A Prostaglandin Response That Is Not Inhibited by Aspirin

An Acute Ocular Inflammatory Reaction Induced by Intravitreal Bovine Serum Albumin in Presensitized Rabbits: The Effect of Phentolamine

Prostaglandin E₂in the Vitreous Body of the Normal Rabbit Eye and after Ocular Trauma

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Effects of progesterone on the ocular hypertensive response to prostaglandin

Cited by 10 publications

References 15 publications

Meiosis: A Prostaglandin Response That Is Not Inhibited by Aspirin

Meiosis: A Prostaglandin Response That Is Not Inhibited by Aspirin

An Acute Ocular Inflammatory Reaction Induced by Intravitreal Bovine Serum Albumin in Presensitized Rabbits: The Effect of Phentolamine

Prostaglandin E2in the Vitreous Body of the Normal Rabbit Eye and after Ocular Trauma

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Prostaglandin E₂in the Vitreous Body of the Normal Rabbit Eye and after Ocular Trauma