Effects of progestin–estrogen replacement therapy on QT-dispersion in postmenopausal women

Haseroth, K.; Seyffart, Karen; Wehling, Martin; Christ, Michael

doi:10.1016/s0167-5273(00)00317-x

Cited by 54 publications

(52 citation statements)

References 18 publications

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“…Likewise, acute administration of supraphysiological doses of estrogen in healthy women produced no significant changes in QT and QTc intervals, whereas both QT and QTc prolonged significantly in women with syndrome X [30]. Haseroth et al [31] demonstrated that combined progestin -estrogen replacement therapy reduces the dispersion of ventricular repolarization in postmenopausal women compared to the control group and estrogen replacement therapy prolongs QT intervals, but does not affect QT dispersion. Larsen et al [18] demonstrated that estrogen, alone or in combination with progestins, had no significant effects on heart rate, QT interval, or corrected QT interval in post menopausal women without a structural heart disease.…”

Section: Discussionmentioning

confidence: 99%

Long term effects of hormone replacement therapy on heart rate variability, QT interval, QT dispersion and frequencies of arrhytmia

Gökçe

Karahan

Yılmaz

et al. 2005

International Journal of Cardiology

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Section: Discussionmentioning

confidence: 99%

Long term effects of hormone replacement therapy on heart rate variability, QT interval, QT dispersion and frequencies of arrhytmia

Gökçe

Karahan

Yılmaz

et al. 2005

International Journal of Cardiology

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“…Larsen, et al 14) have reported that no significant effect of HRT (estrogen or estrogen plus progesterone) was seen on the QT interval or QTc interval, and the estrogen effect in the dosages and forms given clinically should not increase a woman's risk for torsades de pointes. On the other hand, in a study conducted by Haseroth, et al 17) women receiving HRT for 3 months were separated into two groups-those given only estrogen and others given estrogen plus progesterone-and they were compared with the control group. Contrary to the study reported by Saba, et al in this study it was reported that QTd did not change, while QT duration was prolonged in the group administered only estrogen replacement.…”

Section: Discussionmentioning

confidence: 99%

Effects of Long-Term Hormone Replacement Therapy on QT and Corrected QT Dispersion during Resting and Peak Exercise Electrocardiography in Post-Menopausal Women.

et al. 2002

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SUMMARYIt is known that the QT interval is longer in women than men. Estrogen is reported to account for the QT interval prolongation in several studies conducted with hormone replacement therapy (HRT) in postmenopausal women. Along with this, there are conflicting data as regards the effects of HRT on QT interval and dispersion. Moreover, there is no evidence about the effect of HRT on exercise QT parameters.We compared QT parameters obtained from surface electrocardiograms during resting and peak exercise before and after 6 months of HRT consisting of estrogen plus progesterone in healthy postmenopausal women. Twenty-four healthy postmenopausal women were given 0.625 mg/day conjugated estrogens and 2.5 mg/day medroxyprogesterone acetate for 6 months. Exercise stress testing using the Bruce protocol was performed before and after HRT. QT maximum, minimum, dispersion and corrected QT maximum, minimum and dispersion were calculated during resting and peak exercise.HRT resulted in a significant increase in estradiol plasma levels from 24±10 pg/mL to 117±66 pg/mL (P<0.001). There was no significant difference in resting QT parameters after HRT, whereas QT dispersion and corrected QT dispersion were significantly increased during peak exercise (20±7 versus 25±10 ms; P<0.05, 33±12 versus 41±16 ms; P<0.05, respectively). Nonetheless, the other exercise QT parameters were unchanged.The resting QT parameters are not affected by long term HRT consisting of estrogen plus progesterone, which leads to an increase in QT dispersion and corrected QT dispersion during peak exercise. (Jpn Heart J 2002; 43: 1-7)

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“…On the other hand, a study in which women receiving HRT for 3 months were separated into two groups-those given only estrogen and others given estrogen plus progesterone-showed that QT dispersion (QTd) did not change, while QT duration was prolonged in the group with only estrogen replacement. In the same study it was stated that QTd decreased in the group receiving estrogen plus progesterone [15]. As a result, it was stated that HRT including estrogen plus progesterone homogenized the QT duration and therefore decreased the QTd.…”

Section: Discussionmentioning

confidence: 84%

Electrical Storms after Levonorgestrel (Synthetic Progestin)-Releasing Intra-Vaginal Device Insertion. A Case Report and a Short Review of Literature

Fasullo¹,

Maringhini²,

Fasullo³

et al. 2018

OJOG

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We report a case of arrhythmic storm in a patient with recent vaginal insertion of a device with release of levonorgestrel (synthetic progestin). A woman of 60 years was hospitalized for runs of monomorphic sustained ventricular tachycardia. She received a vaginal device levonorgestrel-releasing 2 days before admission. No history of associated cardiovascular or thyroid disease or risk factors was reported. Laboratory parameters as well as ECG and echocardiogram were normal. After 48 hours from removal of the vaginal device, the patient was asymptomatic and showed only single ectopic beats, sometimes in pairs. The subsequent coronary angiography, electrophysiological study and cardiac magnetic resonance resulted negative.

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Effects of progestin–estrogen replacement therapy on QT-dispersion in postmenopausal women

Cited by 54 publications

References 18 publications

Long term effects of hormone replacement therapy on heart rate variability, QT interval, QT dispersion and frequencies of arrhytmia

Long term effects of hormone replacement therapy on heart rate variability, QT interval, QT dispersion and frequencies of arrhytmia

Effects of Long-Term Hormone Replacement Therapy on QT and Corrected QT Dispersion during Resting and Peak Exercise Electrocardiography in Post-Menopausal Women.

Electrical Storms after Levonorgestrel (Synthetic Progestin)-Releasing Intra-Vaginal Device Insertion. A Case Report and a Short Review of Literature

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