Effects of Proline-Rich Peptides of the Innate Immune System on Drug-Resistant Bacterial Strains

Caprine Bactenecins as Promising Tools for Developing New Antimicrobial and Antitumor Drugs

“…The present research is devoted to a comprehensive study of a biological activity of a caprine bactenecin ChBac3.4, which we have previously isolated from the goat leukocytes (Shamova et al, 2009) along with the other PR-AMPs-mini-ChBac7.5Na and -b, ChBac5 (Shamova et al, 1999;Shamova et al, 2016)-and showed that they possess a marked activity against multidrug-resistant bacterial strains of Gram-negative hospital isolates (Zharkova et al, 2018). While minibactenecins and ChBac5 had similar capabilities with those of bovine ortologs, ChBac3.4 exerted a wider spectrum of antibacterial activity and therefore has been chosen for a more detailed study.…”

“…The names are derived from Capra hircus and peptide size. We have shown that chemically synthesized ChBac3.4, ChBac5, mini-ChBac7.5Na, mini-ChBac7.5Nb exhibit a pronounced in vitro antimicrobial activity against drug-resistant clinical isolates (Escherichia coli, Acinetobacter baumannii, Pseudomonas aeruginosa, Klebsiella pneumoniae) (Shamova et al, 2017;Zharkova et al, 2018).…”