Effects of propafenone on ventricular arrhythmias: Double-blind, parallel, randomized, placebo-controlled dose-ranging study

Singh, Bramah N.; Kaplinsky, Elieser; Kirsten, Edward B.; Guerrero, Julio Becerra

doi:10.1016/0002-8703(88)90741-7

Cited by 22 publications

(7 citation statements)

References 41 publications

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“…Propafenone was effective in 17 of 30 patients (57%), a result consistent with those reported previously. [5][6][7][8][9] In addition, the present study showed the equivalent effectiveness of propafenone on the groups with either a positive (n=10, 70%) or bidirectional (n=15, 67%) type of PVC-HR correlation. However, propafenone was not effective in any of the 5 patients (0%) with negative or flat correlations.…”

Section: Discussionsupporting

confidence: 64%

“…Although many papers have been published regarding the efficacy of propafenone on PVCs, [5][6][7][8][9] few have analyzed its mode of action. 16,17) To our knowledge, the present study is the first report which describes the action of propafenone on PVCs in terms of its heart rate dependency, as well as assessing its effect on CI.…”

Section: Discussionmentioning

confidence: 99%

“…[5][6][7][8][9] Few noninvasive studies have been performed, however, using ambulatory ECG monitoring to investigate the action of propafenone in relation to the mechanisms of ventricular arrhythmias on Japanese patients. Furthermore, previous studies using propafenone have not provided a satisfactory outcome using Holter ECG monitoring for predicting the different types of heart rate dependency of ventricular arrhythmias.…”

mentioning

confidence: 99%

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The Effect of Propafenone on Premature Ventricular Contractions (PVC). An Analysis Based on Heart Rate Dependency of PVCs.

Saikawa

Niwa

Ito³

et al. 2001

Jpn Heart J

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SUMMARYThe effect of 450 mg/day propafenone for two weeks on premature ventricular contractions (PVCs) was studied in combination with an assessment of heart rate (HR) dependency of PVCs using Holter ECG monitoring in patients with more than 720 PVCs per day. The PVC-HR correlation was classified into positive (P), bidirectional (B), and flat and negative (FN) correlation groups. The positive group included only patients in whom PVC frequency increased with a heart rate increase, while the bidirectional group included patients with PVCs whose frequency increased at low heart rates and decreased at high heart rates. The FN group contained both flat (PVC frequency was almost fixed regardless of heart rate changes) and negative (PVC frequency decreased as heart rate increased) correlations. The effectiveness of propafenone was 70% in the positive group and 50% in the nonpositive group which included both bidirectional (67%) and FN (0%) groups, using a > 70% PVC reduction as a criterion of efficacy. From this, we concluded that propafenone is effective in patients showing either positive or bidirectional PVC-HR correlation. The coupling interval (CI) of PVCs was also prolonged by propafenone as a whole. The present study suggests that there are differences in the mechanism of PVC development in patients with flat or negative correlation and those with a positive or bidirectional correlation. Thus, this type of analysis contributes to an understanding of the action of antiarrhythmic agents, and may allow the prediction of their efficacy on PVCs. (Jpn Heart J 2001; 42: 701-711)

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Section: Discussionsupporting

confidence: 64%

Section: Discussionmentioning

confidence: 99%

mentioning

confidence: 99%

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The Effect of Propafenone on Premature Ventricular Contractions (PVC). An Analysis Based on Heart Rate Dependency of PVCs.

Saikawa

Niwa

Ito³

et al. 2001

Jpn Heart J

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“…Singh et al examined propafenone's dose‐response relationship in 226 patients with Lown grade 2 premature ventricular contractions (greater than or equal to 30 per hour) documented on 24‐hour Holter recordings. Less than 5% of patients developed first‐degree AV block or intraventricular conduction defect and the occurrence of side effects was not related to dose 23 . In our study, propafenone‐related AV block was reversible in one case and two patients underwent PM implantation due to a persistent AV block.…”

Section: Discussionmentioning

confidence: 42%

Management of Patients with Drug‐Induced Atrioventricular Block

Osmonov

Erdinler

Özcan

et al. 2012

Pacing Clinical Electrophis

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“…The antiarrhythmic potential of these AADs for the suppression and termination of VA has been mainly studied until the 1990s. [34][35][36][37] However, in the setting of ACS, these drugs may cause an aggravation of VT/VF. After the publication of the CAST trial that has shown an increased mortality in patients after MI treated with encainide, flecainide, or moricizine as compared with placebo, further research to class IAAD and VA has largely been abandoned.…”

Section: Antiarrhythmic Therapy In Patients With Sustained Ventriculamentioning

confidence: 99%

Cardiac arrhythmias in acute coronary syndromes: position paper from the joint EHRA, ACCA, and EAPCI task force

Görenek¹,

Lundqvist²,

Terradellas³

et al. 2015

EuroIntervention

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Recurrent VT/VF and Electrical Storm in ACS Cardioversion/defibrillation Overdrive pacing Attempt complete revascularization Treat ischaemia Correct electrolyte imbalance β-blocker therapy Deep sedation Recurrent VT/VF Amiodarone Lidocaine Consider catheter ablation Electrical Storm Amiodarone Consider ICD reprogramming Consider catheter ablation Consider LVAD implantation Cardiac arrhythmias in acute coronary syndromes EuroIntervention 2014;10-online publish-ahead-of-print August 2014

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Effects of propafenone on ventricular arrhythmias: Double-blind, parallel, randomized, placebo-controlled dose-ranging study

Cited by 22 publications

References 41 publications

The Effect of Propafenone on Premature Ventricular Contractions (PVC). An Analysis Based on Heart Rate Dependency of PVCs.

The Effect of Propafenone on Premature Ventricular Contractions (PVC). An Analysis Based on Heart Rate Dependency of PVCs.

Management of Patients with Drug‐Induced Atrioventricular Block

Cardiac arrhythmias in acute coronary syndromes: position paper from the joint EHRA, ACCA, and EAPCI task force

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