Effects of Propofol and Ketamine as Induction Agent to Isoflurane and as Continuous Rate Infusion on Haematobiochemical Parameters in Dogs Premedicated with Glycopyrrolate, Dexmedetomidine and Butorphanol

Abstract

Background: The study was conducted to evaluate the effect of propofol and ketamine as induction agent to isoflurane and as continuous rate infusion on haematobiochemical parameters in dogs premedicated with glycopyrrolate, dexmedetomidine and butorphenol. Methods: Twenty four animals were randomly divided into four Groups (A, B, C and D) comprising six animals in each. All the animals were premedicated with glycopyrrolate, dexmedetomidine and Butorphanol. Induction was done with propofol in group A and B and with ketamine in group C and D. Anaesthesia was maintained with isoflurane in group A and C and with propofol and ketamine continuous rate infusion in group B and D, respectively. Blood samples were collected at 0(before premedication), 20, 40 and 60 min (during maintenance) to evaluate different haematobiochmical parameters. Result: The haemoglobin levels decreased in all the groups but significantly in Group C and Group D. The total erythrocyte count decreased in all the groups with significant change in Group D. The TLC, PCV, platelet, lymphocyte and monocyte count decreased non-significantly. The neutrophil, granulocyte count in all the groups increased non-significantly over the different observation period. The serum glucose and LDH increased significantly in all the groups. The GGT, alkaline phosphatise, BUN and serum creatinine increased non-significantly in all the groups.