Effects of Propofol Intravenous Anesthesia on Serum NGF, S100B Protein, and Immune Function in Patients with Bladder Cancer after Resection

Guan, Xiaohong; Peng, Qingxiong; Liu, Yongping; Wang, Jiansong

doi:10.1155/2022/5409323

Cited by 3 publications

(6 citation statements)

References 17 publications

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“…Among the LFPI rats, we also found that high 2d‐S100B plasma levels also correlated with better neuromotor functional recovery. Among the peri‐operative factors, recent isoflurane anesthesia, as used in our study, may result in low plasma S100B levels in rabbits 3d after embolic stroke, 53 as well as in patients who underwent bladder cancer resection surgery 54 . The effects of isoflurane on plasma pTAU‐Thr 231 are unknown.…”

Section: Discussionmentioning

confidence: 79%

“…Among the peri-operative factors, recent isoflurane anesthesia, as used in our study, may result in low plasma S100B levels in rabbits 3d after embolic stroke, 53 as well as in patients who underwent bladder cancer resection surgery. 54 The effects of isoflurane on plasma pTAU-Thr 231 are unknown. Craniotomy may also produce mild pathologies in the brain, 55 as also shown here by the mild impairment of neuroscores F I G U R E 3 Effects of early post-LFPI seizures and LEV upon protein biomarkers in LFPI rats.…”

Section: Discussionmentioning

confidence: 99%

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Early preclinical plasma protein biomarkers of brain trauma are influenced by early seizures and levetiracetam

et al. 2023

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Objective We used the lateral fluid percussion injury (LFPI) model of moderate‐to‐severe traumatic brain injury (TBI) to identify early plasma biomarkers predicting injury, early post‐traumatic seizures or neuromotor functional recovery (neuroscores), considering the effect of levetiracetam, which is commonly given after severe TBI. Methods Adult male Sprague–Dawley rats underwent left parietal LFPI, received levetiracetam (200 mg/kg bolus, 200 mg/kg/day subcutaneously for 7 days [7d]) or vehicle post‐LFPI, and were continuously video‐EEG recorded (n = 14/group). Sham (craniotomy only, n = 6), and naïve controls (n = 10) were also used. Neuroscores and plasma collection were done at 2d or 7d post‐LFPI or equivalent timepoints in sham/naïve. Plasma protein biomarker levels were determined by reverse phase protein microarray and classified according to injury severity (LFPI vs. sham/control), levetiracetam treatment, early seizures, and 2d‐to‐7d neuroscore recovery, using machine learning. Results Low 2d plasma levels of Thr231‐phosphorylated tau protein (pTAU‐Thr231) and S100B combined (ROC AUC = 0.7790) predicted prior craniotomy surgery (diagnostic biomarker). Levetiracetam‐treated LFPI rats were differentiated from vehicle treated by the 2d‐HMGB1, 2d‐pTAU‐Thr231, and 2d‐UCHL1 plasma levels combined (ROC AUC = 0.9394) (pharmacodynamic biomarker). Levetiracetam prevented the seizure effects on two biomarkers that predicted early seizures only among vehicle‐treated LFPI rats: pTAU‐Thr231 (ROC AUC = 1) and UCHL1 (ROC AUC = 0.8333) (prognostic biomarker of early seizures among vehicle‐treated LFPI rats). Levetiracetam‐resistant early seizures were predicted by high 2d‐IFNγ plasma levels (ROC AUC = 0.8750) (response biomarker). 2d‐to‐7d neuroscore recovery was best predicted by higher 2d‐S100B, lower 2d‐HMGB1, and 2d‐to‐7d increase in HMGB1 or decrease in TNF (P < 0.05) (prognostic biomarkers). Significance Antiseizure medications and early seizures need to be considered in the interpretation of early post‐traumatic biomarkers.

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Section: Discussionmentioning

confidence: 79%

Section: Discussionmentioning

confidence: 99%

Early preclinical plasma protein biomarkers of brain trauma are influenced by early seizures and levetiracetam

et al. 2023

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“…17 Several mechanisms by which propofol specifically exerts antitumor effects on bladder cancer have also been presented. [6][7][8][9][10] In addition, meta-analyses indicate a survival benefit with propofol-based anesthesia for various cancers. [18][19][20][21] Please note that the 5-yr survival rates were calculated using the Kaplan-Meier approach, adjusting for the patients that were censored during follow-up.…”

Section: Discussionmentioning

confidence: 99%

“…The designation "quality register," which is necessary to obtain government funding, is given to both registries (Supplemental Digital Content 1, https://links.lww.com/ ALN/D487). The data analysis and statistical plan used for a similar study on breast cancer, 10 which was written and filed at https://regionvastmanland.se/vardgivare/forskning-och-utbildning/forskning/ in February 2020, was used for this study as well. A similar propensity score approach was implemented but with different clinical variables and sensitivity analysis corresponding to bladder cancer subtypes and outcomes.…”

Section: Methodsmentioning

confidence: 99%

“…4 Finally, a randomized, controlled trial comparing the combination of propofol and paravertebral block with sevoflurane and opioids showed noninferiority in cancer recurrence between the two groups. 5 However, specific to bladder cancer, a few in vitro studies [6][7][8][9] and one clinical study 10 indicate that propofol interferes positively with the immune system against bladder cancer by regulation of several different microRNA pathways and the Hedgehog pathway. However, it is unclear whether these proposed advantages really translate to better survival.…”

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confidence: 99%

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Long-term Survival after Volatile or Propofol General Anesthesia for Bladder Cancer Surgery: A Retrospective National Registry Cohort Study

Enlund,

Hållberg,

Berglund

et al. 2024

Anesthesiology

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Background Prospective interventional trials and retrospective observational analyses provide conflicting evidence regarding the relationship between propofol versus inhaled volatile general anesthesia and long-term survival after cancer surgery. In specific, bladder cancer surgery lacks prospective clinical trial evidence. Methods Data on bladder cancer surgery performed under general anesthesia between 2014 and 2021 from The National Quality Registry for Urinary Tract and Bladder Cancer and the Swedish Perioperative Registry were record-linked. Overall survival was compared between patients receiving propofol or inhaled volatile for anesthesia maintenance. The minimum clinically important difference was defined as a five-percentage point difference in five-year survival. Results Of 7,571 subjects, 4,519 (59.7%) received an inhaled volatile anesthetic and 3,052 (40.3%) received propofol for general anesthesia maintenance. The two groups were quite similar in most respects but differed in ASA physical status and tumor stage. Propensity score matching was used to address treatment bias. Survival did not differ during follow-up (median 45 months [interquartile range, 33 to 62]) in neither the full unmatched cohort, nor following 1:1 propensity score matching (3,052 matched pairs). The Kaplan-Meier adjusted five-year survival rates in the matched cohort were 898/3,052, 67.5% (65.7-69.3) for propofol and 852/3,052, 68.5% (66.7-70.4) for inhaled volatile general anesthesia, respectively (hazard ratio 1.05 [95% CI: 0.96 to 1.15], P = 0.332). A sensitivity analysis restricted to 1,766 propensity score matched pairs of patients who received only one general anesthetic during the study period did not demonstrate a difference in survival; Kaplan-Meier adjusted five-year-survival rates were 521/1,766, 67.1% (64.7-69.7) and 482/1,766, 68.9% (66.5-71.4) for propofol and inhaled volatile general anesthesia, respectively (hazard ratio 1.09 [95% CI: 0.97 to 1.23], P = 0.139). Conclusions Among patients undergoing bladder cancer surgery under general anesthesia, there was no statistically significant difference in long-term overall survival associated with the choice of propofol or an inhaled volatile maintenance.

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Co-expression prognostic-related genes signature base on propofol and sevoflurane anesthesia predict prognosis and immunotherapy response in glioblastoma

Hou

Luo

et al. 2023

Annals of Medicine

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Objectives Anesthetic drugs had been reported may impact the bio-behavior of the tumor. Propofol and sevoflurane are common anesthetics in the operation for glioblastoma (GBM). This study aims to establish a co-expression prognostic-related genes signature base on propofol and sevoflurane anesthesia to predict prognosis and immunotherapy response in GBM. Method GPM tissues with different anesthetics gene expression profiles (GSE179004) were obtained from the Gene Expression Omnibus (GEO) database. Core modules and central genes associated with propofol and sevoflurane anesthesia were identified by weighted gene coexpression network analysis (WGCNA) and establish a risk score prognostic model. Immune cell signature analysis in TCGA datasets was predicted via CIBERSORT. At last, serum methylation level of O6-methylguanine-DNA methyltransferase (MGMT) promoter was detected in GPM patient in different time during perioperative period. Results The burlywood1 group screened was significantly associated with sevoflurane-treated GBM tissue. 22 independent prognostic differential genes were construct a prognostic-related genes risk score in GBM, and showed good predictive ability. The risk score was strongly correlated with the age of the patients, but not with the sex of the patients. In addition, the differential responses to immunotherapy in high and low risk groups were analyzed, indicating that sevoflurane signature genes were consistent in the classification of gliomas. High-risk patients have high T-cell damage score and are less sensitive to immunotherapy. At last, serum methylation level of MGMT promoter was decreased in GBM patients during propofol and sevoflurane anesthesia. Conclusions Propofol and sevoflurane anesthesia associated impact on the gene expression of GBM, included the methylation level of MGMT promoter. Propofol and sevoflurane anesthesia-based risk score prognostic model, which has good prognostic power and is an independent prognostic factor in GBM patients. Therefore, this model can be used as a new biomarker for judging the prognosis of GBM patients. KEY MESSAGES Propofol and sevoflurane anesthesia-based risk score prognostic model has good prognostic power and is an independent prognostic factor in GBM patients. High Propofol and sevoflurane anesthesia-based risk score GBM patients have high T-cell damage scores and are less sensitive to immunotherapy. Serum methylation level of MGMT promoter decrease during propofol and sevoflurane anesthesia in GBM patients.

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Effects of Propofol Intravenous Anesthesia on Serum NGF, S100B Protein, and Immune Function in Patients with Bladder Cancer after Resection

Cited by 3 publications

References 17 publications

Early preclinical plasma protein biomarkers of brain trauma are influenced by early seizures and levetiracetam

Early preclinical plasma protein biomarkers of brain trauma are influenced by early seizures and levetiracetam

Long-term Survival after Volatile or Propofol General Anesthesia for Bladder Cancer Surgery: A Retrospective National Registry Cohort Study

Co-expression prognostic-related genes signature base on propofol and sevoflurane anesthesia predict prognosis and immunotherapy response in glioblastoma

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