Effects of propolis and melatonin on oxidative stress, inflammation, and clinical status in patients with primary sepsis: Study protocol and review on previous studies

Pahlavani, Naseh; Sedaghat, Alireza; Moghaddam, Ahmad Bagheri; Kiapey, Seyedeh Shabnam Mazloumi; Navashenaq, Jamshid Gholizadeh; Jarahi, Lida; Reazvani, Reza; Norouzy, Abdolreza; Nematy, Mohsen; Safarian, Mohammad; Ghayour‐Mobarhan, Majid

doi:10.1016/j.clnesp.2019.06.007

Cited by 35 publications

(24 citation statements)

References 46 publications

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“…The strengths of the present study include: the design of the classi ed blocks randomization was used to randomly assign participants to 4 groups of the study that this scheme led to the homogeneous distribution of features between the groups and the control of the confounders, and second strengths in this study, for the rst time, the co-administration effect of propolis and melatonin supplements in an acute condition and in critically ill patients was measured. The limitations of the present study were the inability to measure all the factors predicted in the study protocol (26), and small sample size due to nancial constraints.…”

Section: Discussionmentioning

confidence: 93%

“…The trial was a single center, prospective, randomized, controlled trial that conducted in critically ill patient with primary sepsis between December 2018 and October 2019 in the Intensive Care Units, Imamreza Hospital. The study protocol and consent forms were approved by the Research Ethics Committee of Mashhad University of Medical Sciences (registration code: IR.MUMS.MEDICAL.REC.1397.290) and was registered in the Iranian Registry of Clinical Trials (registration code: IRCT20181025041460N1) (26). Written informed consent was obtained from all patients or their legal representatives before inclusion in the study.…”

Section: Methodsmentioning

confidence: 99%

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The Effects of Melatonin and Propolis on Markers of Inflammation, Oxidative Stress, Clinical Outcomes, and Survival Rate in Patients with Primary Sepsis Hospitalized in Intensive Care Unit: A Randomized Clinical Trial

Pahlavani

Sedaghat

Ferns

et al. 2020

Preprint

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Background: Systemic Inflammatory Response Syndrome (SIRS) that occurs under stressful conditions affecting all organs of the body. Previous studies have shown that propolis and melatonin have the potential to improve inflammation and oxidative stress, so the aim of this study was to investigate the effects of these supplements on SIRS treatment.Method: This was a randomized, controlled clinical trial in SIRS patients comprising 55 subjects that were randomly assigned to 3 intervention or control groups. In the 3 intervention groups, patients were treated with propolis alone (at dose of 1000 mg/day), propolis (1000 mg/day) plus melatonin (20 mg/day), and melatonin alone (20 mg/day) respectively, while there was no intervention in the control group. The inflammatory and oxidative stress markers and clinical outcomes were measured before and after of the intervention, also 28-day survival rate was assessed. Results: Propolis plus melatonin reduced serum interleukin 6 (p = 0.001) and CRP levels (p <0.001), and was associated with an increased gavage intake (p = 0.016). At the end of the study, there was no difference between the groups in the oxidative stress and hematological indices. In the propolis+melatonin group, the clinical outcomes were significantly improved (p <0.05). Also the SOFA score between the groups did not differ at any time, its changes was significant during the time (p>0.001). The average survival after 28 days of follow-up in the propolis, propolis+melatonin, melatonin and control groups were 24.08, 25.69, 22.05 and 19.42 days respectively, although this was not statistically significant (p=0.07).Conclusion and relevance: Supplementation with propolis+melatonin may help to improve clinical outcomes by reducing inflammation and was probably associated with an increase in the calorie intake, leading to an increase in the survival rate in SIRS patients, although more studies are necessary to prove these effects. Trial registration: IRCT20181025041460N1.

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Section: Discussionmentioning

confidence: 93%

Section: Methodsmentioning

confidence: 99%

The Effects of Melatonin and Propolis on Markers of Inflammation, Oxidative Stress, Clinical Outcomes, and Survival Rate in Patients with Primary Sepsis Hospitalized in Intensive Care Unit: A Randomized Clinical Trial

Pahlavani

Sedaghat

Ferns

et al. 2020

Preprint

Self Cite

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“…Propolis contains over 300 potentially active ingredients, including coumarins, phenolic aldehydes, steroids, amino acids and polyphenols [26]. Its functions as an immune enhancer, antibacterial, anti-inflammatory, anti-tumour and antioxidant agent have been investigated [27,28]. The antioxidant properties of propolis are contributors to its other biological effects, including chemoprevention [29] and antiinflammation [30].…”

Section: Introductionmentioning

confidence: 99%

Application of Propolis in Protecting Skeletal and Periodontal Health—A Systematic Review

Ekeuku

Chin

2021

Molecules

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Chronic inflammation and oxidative stress are two major mechanisms leading to the imbalance between bone resorption and bone formation rate, and subsequently, bone loss. Thus, functional foods and dietary compounds with antioxidant and anti-inflammatory could protect skeletal health. This review aims to examine the current evidence on the skeletal protective effects of propolis, a resin produced by bees, known to possess antioxidant and anti-inflammatory activities. A literature search was performed using Pubmed, Scopus, and Web of Science to identify studies on the effects of propolis on bone health. The search string used was (i) propolis AND (ii) (bone OR osteoporosis OR osteoblasts OR osteoclasts OR osteocytes). Eighteen studies were included in the current review. The available experimental studies demonstrated that propolis could prevent bone loss due to periodontitis, dental implantitis, and diabetes in animals. Combined with synthetic and natural grafts, it could also promote fracture healing. Propolis protects bone health by inhibiting osteoclastogenesis and promoting osteoblastogenesis, partly through its antioxidant and anti-inflammatory actions. Despite the promising preclinical results, the skeletal protective effects of propolis are yet to be proven in human studies. This research gap should be bridged before nutraceuticals based on propolis with specific health claims can be developed.

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“…The disease can be asymptomatic or present mild affection of the upper respiratory tract, while in the most severe cases is characterized by acute respiratory distress syndrome, heart failure, and septic shock [6]. Nutritional support using different methods has always played a crucial role in reducing inflammation and oxidative stress in the prevention, control and treatment of infectious and pulmonary diseases, and it seems that meeting the nutritional needs of patients with Covid-19 can help improve the disease process [7][8][9][10][11][12][13]. This mini-review study provides…”

Section: Introductionmentioning

confidence: 99%

Current Nutritional Support in Critical Ill Covid-19 Patients: A Brief Review

Pahlavani¹,

JG²

2021

austincritcarej

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Covid-19 is a high prevalence of pneumonia of pathless cause in that started in 2019 in Wuhan, Hubei Province, China. Five to 10% of the coronavirus SARSCoV- 2-infected patients, i.e., with new coronavirus disease 2019 (COVID-19), are presenting with an Acute Respiratory Distress Syndrome (ARDS) requiring urgent respiratory and hemodynamic support in the Intensive Care Unit (ICU). However, nutrition is an important element of care. The nutritional assessment and the early nutritional care management of COVID-19 patients must be integrated into the overall therapeutic strategy. Absence of treatment for this new virus, finding alternative methods to prevent and control the disease is important. Having a well-functioning immune system is essential for the host’s defense against pathogenic organisms. Malnutrition can lead to an impaired immune system during life. Even though the immune system response to infection is itself a factor that could lead to nutritional status impairment. Deficiency of some nutrients can lead to disorders of immune system. Adequate intake of vitamins (A, D, Bs, C and E), minerals (selenium, zinc and iron) and omega-3 fatty acids are among the essential factors in proper immune system function and the international recommendations on nutrition in the ICU should be followed. Some specific issues about the nutrition of the COVID-19 patients in the ICU should be emphasized. We propose a flow chart and ten key issues for optimizing the nutrition management of COVID-19 patients in the ICU.

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Effects of propolis and melatonin on oxidative stress, inflammation, and clinical status in patients with primary sepsis: Study protocol and review on previous studies

Cited by 35 publications

References 46 publications

The Effects of Melatonin and Propolis on Markers of Inflammation, Oxidative Stress, Clinical Outcomes, and Survival Rate in Patients with Primary Sepsis Hospitalized in Intensive Care Unit: A Randomized Clinical Trial

The Effects of Melatonin and Propolis on Markers of Inflammation, Oxidative Stress, Clinical Outcomes, and Survival Rate in Patients with Primary Sepsis Hospitalized in Intensive Care Unit: A Randomized Clinical Trial

Application of Propolis in Protecting Skeletal and Periodontal Health—A Systematic Review

Current Nutritional Support in Critical Ill Covid-19 Patients: A Brief Review

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