Effects of propolis on blood glucose, blood lipid and free radicals in rats with diabetes mellitus

Hu, Fenglin; Hepburn, H. R.; Han, Xuan; Chen, Minli; Daya, Santy; Radloff, Sarah E.

doi:10.1016/j.phrs.2004.06.011

Cited by 169 publications

(151 citation statements)

References 15 publications

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“…Fulianga et al [33] explained that the intake of Chinese honeybee gum orally led to lower total cholesterol levels, triglycerides, and low and very low density lipoproteins in the blood serum.…”

Section: Resultsmentioning

confidence: 99%

Effect of Saudi Propolis on Hepatitis Male Rats

E¹,

Elhendy²,

Mas³

et al. 2017

J Nutr Food Sci

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This study was conducted to evaluate the benefits of the Saudi gum (propolis) by reduction of the toxic substances in rats that target the liver and affect its performance. The chemical components of propolis were identified. The study included 42 Albino male rat of a healthy weight ranged from 255-287 g, and they were divided into six equal groups. The first group was fed the standard diet (negative control group), while the other 35 rats were injected with carbon tetrachloride under the skin (1.5 ml/ kg) in order to infect them with acute hepatitis. After 24 h, the groups of infected rats were divided and the second group (positive control group) was also fed a standard meal, while the other groups infected which were the third, fourth, fifth and sixth were fed on a diet with access to a standard concentration of Saudi bee gum of 200, 300, 400 and 500 mg/kg, respectively, through the mouth for 4 consecutive weeks. The results showed that propolis contains 41 compounds and out of these 17 compounds have been identified. Volatile oil was in proportion of 20.37%, aliphatic acids in 16.87%, and esters in 15.48% and alcohols in 13.98%. The results showed a significant improvement in the biochemical parameters in hepatitis rats which were treated with propolis. Results also showed that propolis increased the activity of antioxidant enzymes in the liver of hepatitis rats treated with propolis. The study concluded that propolis plays an effective role in protecting the liver from damage and inflammation that can be caused by the components of antioxidation and inflammation.

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Section: Resultsmentioning

confidence: 99%

Effect of Saudi Propolis on Hepatitis Male Rats

E¹,

Elhendy²,

Mas³

et al. 2017

J Nutr Food Sci

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show abstract

“…This result, as indicated above, may be related to the dose administered and the single administration. As in a study conducted by Matsui et al [28] with rats, propolis was determined to cause a decrease in glucose levels, and also Fuliang et al [12] reported it decreased triglyceride and cholesterol levels in rats.…”

Section: Administration Of Propolis Alonementioning

confidence: 86%

Effecs of Cypermethrin on Some Biochemical Changes in Rats: The Protective Role of Propolis

et al. 2008

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“…Water or ethanolic extract of propolis administration for seven weeks to STZ-induced diabetic rats decreased glucose, total cholesterol and triglycerides levels, and nitric oxide synthase activity, suggesting that propolis may control blood glucose and modulate glucose and lipid metabolism, leading to decreased outputs of lipid peroxidation and scavenging the free radicals in diabetic rats (22). It has been also reported that the eight-week treatment with caffeic acid phenethyl ester (CAPE), an active component of propolis, reduced the oxidative stress in STZ-induced diabetic rats (23).…”

Section: Resultsmentioning

confidence: 99%

Propolis effect on streptozotocin-induced diabetic rats

Sartori¹,

Kawakami²,

Orsatti³

et al. 2009

J. Venom. Anim. Toxins incl. Trop. Dis

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ABSTRACT:Propolis is one of the hive products that has been used extensively in folk medicine, due to its several biological and pharmacological properties. Besides, propolis-containing products have been intensely marketed by the pharmaceutical industry and health-food stores. This work was carried out in order to investigate whether propolis treatment could revert the metabolic alterations of streptozotocininduced diabetic rats. Animals were kept in metabolic cages and diabetes was induced by a single dose of streptozotocin (35 mg/kg, IV). After a week, rats with glycemia higher than 230 mg/dL were divided into two groups and treated with ethanolic extract of propolis (10 and 90 mg/kg, PO) for seven days. Glycemia and free fatty acids were determined, as well as food and water intake, body weight and urine volume were registered weekly. Data showed no significant differences in the analyzed variables. Based on these results, one may conclude that propolis had no effects after diabetes establishment, in our conditions assays. Further assays with different concentrations of propolis and periods of administration should be carried out in order to evaluate its therapeutic potential in this disease. KEY WORDS:Brazilian propolis, diabetes, glucose, free fatty acids. CONFLICTS OF INTEREST:There is no conflict. CORRESPONDENCE TO:JOSÉ MAURÍCIO SFORCIN, Departamento de Microbiologia e Imunologia, Instituto

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Effects of propolis on blood glucose, blood lipid and free radicals in rats with diabetes mellitus

Cited by 169 publications

References 15 publications

Effect of Saudi Propolis on Hepatitis Male Rats

Effect of Saudi Propolis on Hepatitis Male Rats

Effecs of Cypermethrin on Some Biochemical Changes in Rats: The Protective Role of Propolis

Propolis effect on streptozotocin-induced diabetic rats

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