Effects of propranolol on the modification of trauma memory reconsolidation in PTSD patients: A systematic review and meta-analysis

Raut, Sanket B; Canales, Juan J.; Ravindran, Manoj; Eri, Rajaraman; Benedek, David M.; Ursano, Robert J.; Johnson, Luke R.

doi:10.1016/j.jpsychires.2022.03.045

Cited by 24 publications

(13 citation statements)

References 68 publications

Supporting

Mentioning

Contrasting

Unclassified

Order By: Relevance

“…Last studies have shown that propranolol may also have beneficial effects in other diseases. In post-traumatic stress disorder (PTSD), propranolol did not show a beneficial effect on PTSD symptoms, but significantly reduced the heart rate after traumatic memory recall as compared to placebo ( Raut et al, 2022 ). Research involving propranolol has identified potential cellular and molecular mechanisms involved in tremor reduction and identifies relevant genetic biomarkers for the drug response in essential tremor (ET).…”

Section: Propranolol–an Old Drug With New Propertiesmentioning

confidence: 99%

Beta-blockers in cardiac arrhythmias–Clinical pharmacologist’s point of view

et al. 2023

View full text Add to dashboard Cite

β-blockers is a vast group of antiarrhythmic drugs which differ in their pharmacokinetic and chemical properties. Some of them block β-adrenergic receptors selectively while the others work non-selectively. Consequently, they reduce the influence of the sympathetic nervous system on the heart, acting negatively inotropic, chronotropic, bathmotropic and dromotropic. Although they have been present in medicine since the beginning of the 1960s, they still play a crucial role in the treatment of cardiac arrhythmias. They are also first-line group of drugs used to control the ventricular rate in patients with the most common arrhythmia–atrial fibrillation. Previous reports indicate that infection with SARS-CoV-2 virus may constitute an additional risk factor for arrhythmia. Due to the aging of the population in developed countries and the increase in the number of patients with cardiac burden, the number of people suffering from cardiac arrhythmias will increase in the upcoming years. As a result the role of above-mentioned beta-blockers will remain significant. Particularly noteworthy is propranolol–the oldest beta adrenergic antagonist, which in recent years has found additional applications due to its unique properties. In this article, we reviewed the accessible literature and summarized the current guidelines on the use of beta-blockers in the treatment of cardiac arrhythmias.

show abstract

Section: Propranolol–an Old Drug With New Propertiesmentioning

confidence: 99%

Beta-blockers in cardiac arrhythmias–Clinical pharmacologist’s point of view

et al. 2023

View full text Add to dashboard Cite

show abstract

“…A meta-analysis by Pigeon et al (2022) revealed some evidence for the effectiveness of the propranolol/reactivation approach for reducing intrusive memories and related phenomena in both PTSD patients and nonclinical samples. By contrast, in a broader meta-analysis that included both pharmacological and nonpharmacological manipulations, Astill Wright et al (2021, p. 10) concluded: “We found no overall effect of pharmacological/ECT reconsolidation agents plus MR (memory reminder) procedures on PTSD symptoms, nor any specific effect of propranolol plus MR in subgroup analysis.” Similarly, a meta-analysis by Raut et al (2022) failed to reveal evidence of a significant effect of propranolol on PTSD symptoms in seven studies in which researchers attempted to block reconsolidation, although there was evidence for a reduction in heart rate after recalling a traumatic memory under the influence of propranolol.…”

Section: Persistencementioning

confidence: 99%

“…plus MR in subgroup analysis." Similarly, a meta-analysis by Raut et al (2022) failed to reveal evidence of a significant effect of propranolol on PTSD symptoms in seven studies in which researchers attempted to block reconsolidation, although there was evidence for a reduction in heart rate after recalling a traumatic memory under the influence of propranolol. Further research will be required to sort out the reasons for these differing conclusions, but consistently positive results have come from a series of behavioral studies by Holmes and colleagues, who have attempted to interfere with the initial consolidation or the reconsolidation of traumatic memories by having participants play the computer video game Tetris shortly after memory reactivation (see Holmes et al, 2009, for an early study; see Monfils & Holmes, 2018, for review).…”

Section: Memory Sins In Applied Settingsmentioning

confidence: 99%

Memory sins in applied settings: What kind of progress?

Schacter¹

2022

Journal of Applied Research in Memory and Cognition

View full text Add to dashboard Cite

Over 2 decades ago, I proposed that memory errors could be classified into seven basic categories or sins (Schacter, 1999(Schacter, , 2001, comprising three sins of omission (transience, absentmindedness, and blocking) and four sins of commission (misattribution, suggestibility, bias, and persistence). In the past 2 decades, much has been learned about the nature and basis of the memory sins. Here, I assess the extent of progress that has been made during that time regarding applied implications of five of the sins: transience, absentmindedness, misattribution, suggestibility, and persistence. The manifestations of these sins have been examined in a variety of applied settings, including educational, clinical, legal, and technological domains. I argue that considerable progress has been made in characterizing the impact of memory sins in each domain, identify gaps in and limitations of our current knowledge, and briefly consider how these developments bear on broad questions regarding the reliability of human memory.

show abstract

“…Propranolol was first produced 50 years ago by James Blake 5,6 as a beta blocker to treat angina disease. Propranolol is now known to be effective in treating non‐cardiovascular and cardiology disorders including hypertension, arrhythmias, migraine, and anxiety 7–11 . Although propranolol has been proven to be safe and effective in treating various diseases, 12 it must be noted that propranolol has two stereoisomeric forms, 13,14 both with differing medicinal effect on patients 15,16 .…”

Section: Introductionmentioning

confidence: 99%

An enantioselective study of β‐cyclodextrin and ionic liquid‐β‐cyclodextrin towards propranolol enantiomers by molecular dynamic simulations

Ishak,

Aun,

Sidek

et al. 2024

J Comput Chem

View full text Add to dashboard Cite

In this study, the enantioselectivity of β‐cyclodextrin and its derivatives towards propranolol enantiomers are investigated by molecular dynamic (MD) simulations. β‐cyclodextrin (β‐CD) have previously been shown to be able to recognize propranolol (PRP) enantiomers. To improve upon the enantioselectivity of β‐cyclodextrin, we propose the use of an ionic‐liquid‐modified‐β‐cyclodextrin (β‐CD‐IL). β‐CD‐IL was found to be able to complex R and S propranolol enantiomers with differing binding energies. The molecular docking study reveals that the ionic liquid chain attached to the β‐CD molecule has significant interaction with propranolol. The formation of the most stable complex occurred between (S)‐β‐CD‐IL and (S)‐propranolol with an energy of −5.80 kcal/mol. This is attributed to the formation of a hydrogen bond between the oxygen of the propranolol and the hydrogen on the primary rim of the (S)‐β‐CD‐IL cavity. This interaction is not detected in other complexes. The root mean‐squared fluctuation (RMSF) value indicates that the NH group is the most flexible molecular fragment, followed by the aromatic group. Also of note, the formation of a complex between pristine β‐CD and (S)‐propranolol is the least favorable.

show abstract

Effects of propranolol on the modification of trauma memory reconsolidation in PTSD patients: A systematic review and meta-analysis

Cited by 24 publications

References 68 publications

Beta-blockers in cardiac arrhythmias–Clinical pharmacologist’s point of view

Beta-blockers in cardiac arrhythmias–Clinical pharmacologist’s point of view

Memory sins in applied settings: What kind of progress?

An enantioselective study of β‐cyclodextrin and ionic liquid‐β‐cyclodextrin towards propranolol enantiomers by molecular dynamic simulations

Contact Info

Product

Resources

About