Effects of Propylthiouracil Treatment on Antioxidant Activities in Blood of Toxic Multinodular Goiter Patients

Özdem, Sebahat; Alicigüzel, Yakup; Özdem, Sadi S.; Karayalçın, Ümit

doi:10.1159/000028377

Cited by 18 publications

(27 citation statements)

References 23 publications

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“…2 The effect of PTU on lipid peroxidation has been investigated previously. PTU reduced the extent of lipid peroxidation in both in vivo 24,25 and in vitro 6 studies with this agent. Moreover, PTU, as do other thionamides, has an immunosuppressive action that is beneficial for the treatment of Graves' disease.…”

Section: Discussionmentioning

confidence: 96%

Protective Effect of Propylthiouracil Independent of Its Hypothyroid Effect on Atherogenesis in Cholesterol-Fed Rabbits

et al. 2004

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Background-Propylthiouracil (PTU) is used to treat hyperthyroid patients by its hypothyroid effect. PTU also is found to have potent antioxidant and immunosuppressive effects. These findings suggest that PTU may play a role in the prevention of atherosclerosis. Methods and Results-This study evaluates the effect of PTU on atherosclerotic change in rabbits fed a high-cholesterol diet. The pronounced atherosclerotic lesions in the aortas of rabbits fed a 2% cholesterol diet for 12 weeks were significantly attenuated by the concurrent addition of 0.1% PTU to the drinking water. However, exogenous supplementation of thyroid hormone in hypothyroid PTU-treated rabbits did not abrogate the protective effect of PTU on atherogenesis. Immunohistochemical analysis showed that PTU administration apparently reduced the intimal smooth muscle cell/macrophage ratio in the atherosclerotic plaques of rabbits fed a 2% cholesterol diet. In vitro, the addition of PTU to the medium of cultured rat vascular smooth muscle cells led to a dose-dependent inhibition of cell proliferation and migration. Furthermore, this study confirmed that PTU dose-dependently increased expression of PTEN, a tumor suppressor gene known to be involved in the coordinate inhibition of VSMC proliferation and migration. Conclusions-This study demonstrated that PTU inhibited the development of atherosclerosis through a thyroidindependent mechanism that may be explained, at least in part, by the ability of PTU to inhibit vascular smooth muscle cell proliferation and migration. Furthermore, PTEN induction, via disruption of the phosphatidylinsitol 3-kinasemediated pathway, plays a crucial role in mediating the inhibitory action on vascular smooth muscle cell proliferation and migration.

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Section: Discussionmentioning

confidence: 96%

Protective Effect of Propylthiouracil Independent of Its Hypothyroid Effect on Atherogenesis in Cholesterol-Fed Rabbits

et al. 2004

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“…Hyperthyroidism enhances ROS generation and produces changes in antioxidant systems of various tissues [34]. There are also conflicting reports on the immunosuppressive and free radical scavenging properties of anti-thyroid drugs [35][36][37]. To eliminate the influence of abnormal levels of thyroid hormones, the Graves' patients were included in this study after the achievement of stable euthyroidism by use of the same anti-thyroid drug and treatment protocol.…”

Section: Discussionmentioning

confidence: 99%

Peripheral parameters of oxidative stress in patients with infiltrative Graves’ ophthalmopathy treated with corticosteroids

2004

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“…Firstly, it should be noted, that prooxidant activity of Se was shown to cause upregulation of Se-independent antioxidant enzymes, such as catalase and superoxide dismutase, in different biological systems, and these observations come from plants [169,170], yeast [171], fish [172][173][174][175][176] and, importantly, human cancer cell lines [50,177]. Secondly, such adaptive stress response, specifically with respect to Se-containing enzymes, is also well known to occur following acute and chronic injury 29 human studies [178][179][180][181][182][183][184][185][186][187][188][189][190][191][192][193][194][195][196] showing that selenoproteins (including GPx and Sepp1) are upregulated in the response to oxidative stress from their baseline levels without any change in Se supply and availability, i.e. as a consequence of adaptive response [168].…”

Section: Biochemical Evidencementioning

confidence: 99%

Selenium and Human Health: Witnessing a Copernican Revolution?

Jabłońska

Vinceti

2015

Journal of Environmental Science and Health, Part C

140

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In humans, selenium was hypothesized to lower the risk of several chronic diseases, mainly due to the antioxidant activity of selenium-containing proteins. Recent epidemiologic and laboratory Downloaded by [New York University] at 16:24 19 June 2015 ACCEPTED MANUSCRIPT ACCEPTED MANUSCRIPT 2studies, however, are changing our perception of the biological effects of this nutritionally essential trace element. We reviewed the most recent epidemiologic and biochemical literature on selenium, synthesizing the findings from these studies into a unifying view. Randomized trials have shown that selenium did not protect against cancer and other chronic diseases, but even increased the risk of specific neoplasms such as advanced prostate cancer and skin cancer, in addition to type 2 diabetes. Biochemical studies indicate that selenium may exert a broad pattern of toxic effects at unexpectedly low concentrations. Furthermore, its upregulation of antioxidant proteins (selenium-dependent and selenium-independent) may be a manifestation of self-induced oxidative stress. In conclusion, toxic effects of selenium species occur at lower concentrations than previously believed. Those effects may include a large range of proteomic changes and adverse health effects in humans. Since the effects of environmental exposure to this element on human health still remain partially unknown, but are potentially serious, the toxicity of selenium exposure should be further investigated and considered as a public health priority.

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Effects of Propylthiouracil Treatment on Antioxidant Activities in Blood of Toxic Multinodular Goiter Patients

Cited by 18 publications

References 23 publications

Protective Effect of Propylthiouracil Independent of Its Hypothyroid Effect on Atherogenesis in Cholesterol-Fed Rabbits

Protective Effect of Propylthiouracil Independent of Its Hypothyroid Effect on Atherogenesis in Cholesterol-Fed Rabbits

Peripheral parameters of oxidative stress in patients with infiltrative Graves’ ophthalmopathy treated with corticosteroids

Selenium and Human Health: Witnessing a Copernican Revolution?

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