Effects of Prostaglandin E1 in the Genesis of Blood Capillaries in the Ischemic Skeletal Muscle of Rats: Ultrastructural Analysis

Moreschi, Dorival; Fagundes, Djalma José; Hernandes, Luzmarina; Haapalainen, Edna Freymüller

doi:10.1016/j.avsg.2007.07.035

Cited by 9 publications

(6 citation statements)

References 52 publications

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“…PG E 1 has vasodilating activity, resulting in the inhibition of platelet aggregation and modulation of cell proliferation. 13) PG E 1 has also been reported to have a positive effect on renal function. 14) Combination therapy with corticosteroids and alprostadil may be more effective than monotherapy.…”

Section: Discussionmentioning

confidence: 98%

Treatment of Cholesterol Embolism With Corticosteroids and Alprostadil

Jung

2019

Ann Geriatr Med Res

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Cholesterol embolism is a rare but serious disease that can lead to chronic renal failure or death. Despite the recent increase in the incidence of this disease, there is no consensus on the optimal treatment modality. Supportive care is usually the mainstay of treatment. We report a case of cholesterol embolism after renal artery stenting that was successfully treated with corticosteroids and alprostadil.

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Section: Discussionmentioning

confidence: 98%

Treatment of Cholesterol Embolism With Corticosteroids and Alprostadil

Jung

2019

Ann Geriatr Med Res

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“…It has also been reported that HBO promotes increased blood flow in the microcirculation (angiogenesis) and reduced platelet aggregation. These associated characteristics are combined with a better ability of the plasma to carry dissolved oxygen 29 , 30 .…”

Section: Discussionmentioning

confidence: 99%

Effect of hyperbaric oxygenation on random rat skin flaps vascularization

et al. 2021

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“…On this basis, we hypothesized that the administration of a PGE 1 might enhance the antibiotic delivery in the lower extremities and decrease the bacterial colonization of the infected site. In the present study, the intravenous administration of PGE 1 has been chosen to avoid any potential systemic side effects as also suggested by others [22] .…”

Section: Discussionmentioning

confidence: 99%

“…PGE 1 is already used for the treatment of chronic occlusive arterial disease [18] as either vasodilator or inhibitor of platelet aggregation [15] , [17] , [19] , [20] . PGE 1 plays a role to increase skin and muscle blood flow [21] as well as to generate new blood capillaries in ischemic skeletal muscles [22] . Moreover, the reduction of infections demonstrates the efficacy of PGE 1 in patients with prior irradiation after laryngeal surgeries [23] .…”

Section: Introductionmentioning

confidence: 99%

Does PGE1 Vasodilator Prevent Orthopaedic Implant-Related Infection in Diabetes? Preliminary Results in a Mouse Model

et al. 2014

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BackgroundImplant-related infections are characterized by bacterial colonization and biofilm formation on the prosthesis. Diabetes represents one of the risk factors that increase the chances of prosthetic infections because of related severe peripheral vascular disease. Vasodilatation can be a therapeutic option to overcome diabetic vascular damages and increase the local blood supply. In this study, the effect of a PGE1 vasodilator on the incidence of surgical infections in diabetic mice was investigated.MethodologyA S. aureus implant-related infection was induced in femurs of diabetic mice, then differently treated with a third generation cephalosporin alone or associated with a PGE1 vasodilator. Variations in mouse body weight were evaluated as index of animal welfare. The femurs were harvested after 28 days and underwent both qualitative and quantitative analysis as micro-CT, histological and microbiological analyses.ResultsThe analysis performed in this study demonstrated the increased host response to implant-related infection in diabetic mice treated with the combination of a PGE1 and antibiotic. In this group, restrained signs of infections were identified by micro-CT and histological analysis. On the other hand, the diabetic mice treated with the antibiotic alone showed a severe infection and inability to successfully respond to the standard antimicrobial treatment.ConclusionsThe present study revealed interesting preliminary results in the use of a drug combination of antibiotic and vasodilator to prevent implant-related Staphylococcus aureus infections in a diabetic mouse model.

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Effects of Prostaglandin E1 in the Genesis of Blood Capillaries in the Ischemic Skeletal Muscle of Rats: Ultrastructural Analysis

Cited by 9 publications

References 52 publications

Treatment of Cholesterol Embolism With Corticosteroids and Alprostadil

Treatment of Cholesterol Embolism With Corticosteroids and Alprostadil

Effect of hyperbaric oxygenation on random rat skin flaps vascularization

Does PGE1 Vasodilator Prevent Orthopaedic Implant-Related Infection in Diabetes? Preliminary Results in a Mouse Model

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