Effects of Prostaglandin E1 on Vascular ATP-Sensitive Potassium Channels

Eguchi, Satoru; Kawano, Takashi; Yinhua,; Tanaka, Katsuya; Yasui, Sonoko; Mawatari, Kazuaki; Takahashi, Akira; Nakaya, Yutaka; Oshita, Shuzo; Nakajo, Nobuyoshi

doi:10.1097/fjc.0b013e3181583d9b

Cited by 17 publications

(15 citation statements)

References 27 publications

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“…Whether β-blockade may trigger coronary spasm or protect the post-ischemic myocardium warrants further investigation. Prostaglandin E 1 is generally regarded to have a myocardial protective effect [10]. However, several anecdotal reports in the Japanese literature have demonstrated a temporal coincidence between prostaglandin E 1 administration and the occurrence of coronary spasm [11][12][13].…”

Section: Discussionmentioning

confidence: 99%

Recurrent ST-segment elevation on ECG and ventricular tachycardia during neurosurgical anesthesia

et al. 2009

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Section: Discussionmentioning

confidence: 99%

Recurrent ST-segment elevation on ECG and ventricular tachycardia during neurosurgical anesthesia

et al. 2009

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“…As with BK Ca channels and K V channels, vasodilators that signal through the cAMP signaling pathway activate K ATP channels (Akatsuka et al, 1994; Bouchard, Dumont, & Lamontagne, 1994; Dart & Standen, 1993; Eguchi et al, 2007; Jackson, 1993; Kitazono, Heistad, & Faraci, 1993b; Kleppisch & Nelson, 1995; Ming, Parent, & Lavallee, 1997; Nakashima & Vanhoutte, 1995; C. P. Nelson et al, 2011; M.…”

Section: Potassium Channels and Regulation Of Vsm Contractionmentioning

confidence: 99%

Potassium Channels in Regulation of Vascular Smooth Muscle Contraction and Growth

2017

Advances in Pharmacology

106

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Potassium channels importantly contribute to the regulation of vascular smooth muscle (VSM) contraction and growth. They are the dominant ion conductance of the VSM cell membrane and importantly determine and regulate membrane potential. Membrane potential, in turn, regulates the open-state probability of voltage-gated Ca2+ channels (VGCC), Ca2+ influx through VGCC, intracellular Ca2+ and VSM contraction. Membrane potential also affects release of Ca2+ from internal stores and the Ca2+ sensitivity of the contractile machinery such that K+ channels participate in all aspects of regulation of VSM contraction. Potassium channels also regulate proliferation of VSM cells through membrane potential-dependent and membrane potential-independent mechanisms. Vascular smooth muscle cells express multiple isoforms of at least five classes of K+ channels contribute to the regulation of contraction and cell proliferation (growth). This review will examine the structure, expression and function of large-conductance, Ca2+-activated K+ (BKCa) channels, intermediate-conductance Ca2+-activated K+ (KCa3.1) channels, multiple isoforms of voltage-gated K+ (KV) channels, ATP-sensitive K+ (KATP) channels, and inward-rectifier K+ (KIR) channels in both contractile and proliferating VSM cells.

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“…K ATP channels, working as molecular sensors of cellular metabolism [21] , regulate vascular tone in response to endogenous substances, such as adenosine, noradrenaline and vasopressin [15][16][17][18][19] . We hypothesized that K ATP channels contribute to the BPV after SAD.…”

Section: Discussionmentioning

confidence: 99%

“…However, the definite mechanism by which BPV dramatically increase after SAD surgery is still unclear. ATP-sensitive potassium (K ATP ) channels are critical regulators of vascular tone, forming a focal point for signaling by many vasoactive transmitters, including adenosine, calcitonin gene-related peptide, noradrenaline, insulin, prostaglandin E 1 , and arginine vasopressin [15][16][17][18][19] . It is therefore a molecular sensor, responding to local metabolic need and vasoactive transmitters, altering smooth muscle contractility and so blood flow to retain homeostasis [20][21][22] .…”

Section: Introductionmentioning

confidence: 99%

Role of vascular KATP channels in blood pressure variability after sinoaortic denervation in rats

Yang

Liu

et al. 2011

Acta Pharmacol Sin

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Aim: To investigate the role of ATP-sensitive potassium (K ATP ) channels on blood pressure variability (BPV) in sinoaortic denervated (SAD) rats. Methods: SAD was performed on male Sprague-Dawley rats 4 weeks before the study. mRNA expression of Kir6.1, Kir6.2 and SUR2 in aorta and mesenteric artery was determined using real-time quantitative polymerase chain reaction, and confirmed at the protein level using Western blotting and laser confocal immunofluorescence assays. Concentration-response curves of isolated aortic and mesenteric arterial rings to adenosine and pinacidil were established. Effects of K ATP channel openers and blocker on BPV were examined in conscious SAD rats. Results: Aortic SUR2 expression was significantly greater, while Kir6.1 was lower, in SAD rats than in sham-operated controls. In contrast, in the mesenteric artery both SUR2 and Kir6.1 expression were markedly lower in SAD rats than controls. For both arteries, Kir6.2 expression was indistinguishable between sham-operated and SAD rats. These findings were confirmed at the protein level. Responses of the aorta to both adenosine and pinacidil were enhanced after SAD, while the mesenteric response to adenosine was attenuated. Pinacidil, diazoxide, nicorandil, and glibenclamide significantly decreased BPV. Conclusion: These findings indicate that expression of vascular K ATP channels is altered by chronic SAD. These alterations influence vascular reactivity, and may play a role in the increased BPV in chronic SAD rats.

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Effects of Prostaglandin E1 on Vascular ATP-Sensitive Potassium Channels

Abstract: The results indicate that the activation of vascular KATP channels played an important role in the PKA-dependent PGE1-induced vasorelaxation. Furthermore, an electrophysiological experiment demonstrated that PGE1 activated vascular KATP channels via PKA activation.

Cited by 17 publications

References 27 publications

Recurrent ST-segment elevation on ECG and ventricular tachycardia during neurosurgical anesthesia

Recurrent ST-segment elevation on ECG and ventricular tachycardia during neurosurgical anesthesia

Potassium Channels in Regulation of Vascular Smooth Muscle Contraction and Growth

Role of vascular KATP channels in blood pressure variability after sinoaortic denervation in rats

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