Effects of prostaglandin E1 (PGE1) on experimental renal ischaemia

Torsello, Giovanni; Schrör, Karsten; Szabó, Zsolt; Kutkuhn, B.; Strobach, H.; Godehardt, E.; Sandmann, W.

doi:10.1016/s0950-821x(89)80101-x

Cited by 24 publications

(3 citation statements)

References 20 publications

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“…PGE 1 has been shown to protect against ischemic necrosis of renal tubules [33 ]and to preserve postischemic glomerular filtration rate and renal concentration ability [34] in animals subjected to thoraco-abdominal surgery.…”

Section: Discussionmentioning

confidence: 99%

Role of Combined L-Arginine and Prostaglandin E<sub>1</sub> in Renal Ischemia-Reperfusion Injury

et al. 2007

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Background:L-Arginine (L-arg) and Prostaglandin E₁ (PGE₁) have been used effectively as single agents to ameliorate renal ischemia-reperfusion injury. We hypothesized that combined treatment with L-arg and PGE₁would be more effective. Materials and Methods: The left renal artery of male Sprague-Dawley rats was clamped for 45 min and the right kidney was removed. Fifty six rats were randomly allocated into 5 groups each consisted of 12 rats except sham group (n = 8). (1) sham, underwent right nephrectomy only; (2) control, untreated ischemic rats; (3) L-arg group, L-arg-treated ischemic rats; (4) PGE₁ group, PGE₁-treated ischemic rats; (5) L-arg+PGE₁ group, ischemic rats treated with both L-arg and PGE₁. Renal function and histology were assessed on days 2 and 7 postoperatively. Results: All rats, except control ones, showed a significant improvement of renal function towards normal on postoperative day 7. Serum creatinine and creatinine clearance were significantly better in L-arg+PGE₁ group compared to all other groups on day 7. With the exception of sham-operated and L-arg+PGE₁-treated animals, all other groups showed significant increases in fractional excretion of sodium (FE_Na) in response to renal ischemia-reperfusion. The severest tubular damage was determined in the kidneys of control rats. Rats treated with L-arg+PGE₁ had the least severe tubular damage. Conclusion: The administration of either L-arg or PGE₁ attenuates both functional and structural consequences of renal warm ischemia. A near total protection might be achieved when both agents are administered concomitantly.

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Section: Discussionmentioning

confidence: 99%

Role of Combined L-Arginine and Prostaglandin E<sub>1</sub> in Renal Ischemia-Reperfusion Injury

et al. 2007

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“…Zur Vermeidung einer Stasethrombose werden 2 500 IE Heparin zugesetzt. Der von uns benutzte Zusatz von 40 mg Prostaglandin E1 bietet in experimentellen Untersuchungen tatsächlich eine zusätzliche Ischä-mieprotektion unter Kältebedin-gungen [40]. Darüber hinaus konnten in der chirurgischen Therapie der Nierenarterien bei Stenose, Dissektion, Transplantatarterienstenose und Aneurysma durch die hypotherme Flushperfusion unter fast vollständigem Verzicht auf die Exsitu-Präparation sehr gute Ergebnisse erzielt werden [24,27,28,30].…”

Section: Hypotherme Flushperfusionunclassified

Therapie der Nierenarterienstenosen

Pfeiffer¹,

Müller²,

Huber³

et al. 2004

Herz

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Arterial hypertension is most often the first symptom of renal artery stenosis (RAS). Appropriate screening methods for the diagnostic workup of hypertension are colour-coded duplex ultrasound and captopril scintigraphy. Angiography (intraarterial digital subtraction angiography) represents the diagnostic "gold standard", which is the prerequisite for the selection of the most suitable therapeutic method. Atherosclerosis is the most common disease in elderly patients presenting with RAS. In younger patients, fibromuscular dysplasia is more frequent. Five main types with different prognosis and therapeutic indications can be classified. Rare causes of RAS are dissection, renal artery aneurysm with combined stenosis, and especially in children and adolescents middle aortic syndrome with hypoplasia of the visceral arteries. Every patient with RAS of hemodynamic relevance in the presence of hypertension should be treated, whereas therapeutic risk and benefit must be weighed up individually. Aims are the improvement of hypertension and the maintenance of renal function. Surgical techniques, which are described subsequently, are indicated in all patients who need further simultaneous treatment of the abdominal vessels (abdominal aortic aneurysm, aortoiliac or visceral artery stenosis or aneurysm, respectively). In atherosclerotic ostial stenoses, angioplasty (PTA) and open surgery (normally transaortic endarterectomy) are concurrent methods. In our experience, the long-term results of surgical reconstruction seem to be superior. Both procedures are subject to an ongoing randomized study in our department. The outcome of surgical treatment for RAS is satisfying, the operative risk especially in isolated renal artery lesions is negligible.

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“…Die begrenzte Verlängerung der Ischämietoleranz durch hypotherme Flushperfusion unter Zusatz von Prostaglandin E1 konnte im Tierexperiment am Hund nachgewiesen werden, wobei die natürliche Ischämieto-leranz der Hundeniere deutlich über der des Menschen liegt [34,35]. Die Übertragbarkeit dieser Ergebnisse auf den Menschen ist nicht zuletzt aufgrund der Unterschiede im Metabolismus der im Rahmen der Reperfusion auftretenden freien Sauerstoffradikale problematisch.…”

Section: Kriterien Für Die Auswahl Der Protektionsverfahrensunclassified