Effects of prostaglandin E2, prostaglandin I2 and 6-keto-prostaglandin F1α on adrenergic neurotransmission in the pulmonary artery of th e rabit

Prostacyclin Reversal of Lethal Endotoxemia in Dogs

“…8). The selective reduction of norepinephrine and not dopamine or epinephrine may relate to a direct inhibition of norepinephrine release by PGI2 from sympathetic nerve endings in blood vessels (27). It is also possible that endotoxin interfered with the pulmonary endothelial clearance of norepinephrine.…”

“…24 adult mongrel dogs weighing [21][22][23][24][25][26][27][28][29][30][31][32][33][34][35][36][37][38][39][40] kg were anesthetized with sodium pentobarbital 30 mg/kg, paralyzed with pancuronium bromide 0.1 mg/kg (Organon Inc., West Orange, N. J.…”

Effects of thromboxane synthase inhibition on vascular responsiveness in the in vivo rat mesentery.

“…Prostaglandins can attenuate sympathetic neurotransmission by two basic mechanisms, i.e., by decreasing neurotransmitter release or by reducing the postjunctional responsiveness to NE (13)(14)(15)(16)(17)(18). The first mechanism would alter the effector organ response to nerve activation, but would not modify the effector response to exogenously administered neu- rotransmitter.…”

“…PGI2, PGD2, and PGE2 attenuate the vascular response to vasoconstrictors and inhibit the release of NE from noradrenergic varicosities (13)(14)(15)(16)(17)(18). In contrast, TXA2 may potentiate the vascular response to vasoconstrictors (19,20).…”

RATLARDA ADRENERJİK AKTİviTE ÜZERiNDE PG!, VE PGE;NiN ETKİLERİ

“…Ta.vşan pulmoner aretrinde yapılan bir araştırmada adrenerjik tenbih sonucu oluşan NA salgıhn-masınm PGIı ile inhibe edildiği gösterilmiştir. (19). PGIı'nin belirtilen etkisi presinaptik bir özellik taşıdığı ileri sürülmektedir (ıo).…”