Effects of Prostaglandin F2α, lndomethacin, and Estradiol on Ovum Transport and Pregnancy in the Golden Hamster

Thomas, Chris M.G.; Bastiaans, L.A.; Rolland, R.

doi:10.1095/biolreprod23.4.687

Cited by 5 publications

(4 citation statements)

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“…This is in agreement with the results obtained by others [15,23] suggesting that prostaglandins do not play a significant role in the control of oviductal transport in the hamster. The leukotriene synthesis inhibitor NDGA significantly delayed the transport of embryos to the uterus; the effect was limited to pregnant animals, since oocyte transport in cycling animals was not affected.…”

Section: Discussionsupporting

confidence: 93%

“…Pregnant animals were treated with indomethacin, 6.7 mg/ 100 g BW i.p. (at 2000 h on Day 2 and at 0800 h and 1200 h on Day 3 [15]), or with NDGA, 10 mg/100 g BW i.p. (at 2000 h on Day 2 and at 0800 h and 1600 h on Day 3 [16,17]).…”

Section: Methodsmentioning

confidence: 99%

“…The leukotriene synthesis inhibitor, nordihydroguaiaretic acid (NDGA), was dissolved in Tris-HCI buffer (3.0 M, pH 8.7) at a concentration of 200 mg/ mil. The prostaglandin synthesis inhibitor indomethacin was dissolved in phosphate buffer (0.1 M, pH 8.0) at a concentration of 100 mg/ml [15]. PAF, indomethacin, and NDGA were obtained from Sigma Chemical Company (St. Louis, MO).…”

Section: Drugsmentioning

confidence: 99%

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Possible Role of Platelet-Activating Factor in Embryonic Signaling during Oviductal Transport in the Hamster1

Velásquez

Aguilera

Croxatto³

1995

Biology of Reproduction

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Hamster embryos enter the uterus in pregnant females nearly one day earlier than unfertilized eggs in cycling females. The hypothesis that a substance derived from eicosanoids is released by the embryos, but not by oocytes, to hasten their transport to the uterus was tested by examining the effects of indomethacin, nordihydroguaiaretic acid (NDGA), platelet-activating factor (PAF), and PAF antagonists on egg transport in the hamster. Administration of indomethacin had no effect on embryo transport, whereas administration of NDGA delayed the transport of eggs to the uterus in pregnant but not in cycling hamsters. The PAF antagonists TCV-309 and BN-52021 delayed significantly the transport of eggs to the uterus in pregnant animals, but not in cycling animals; i.e., they retarded the passage of embryos but not of oocytes to the uterus. Administration of PAF to cycling hamsters hastened the oviductal transport of ova. These data suggest that, in the hamster, the earlier passage of embryos to the uterus as compared to oocytes is mediated by PAF. Thrombocytopenia was detected in early-pregnant hamsters, and PAF-like activity was detected in spent media of two-cell through morula stage hamster embryos. These results suggest that preimplantation hamster embryos produce PAF-like activity that mediates embryonic signaling to the oviduct as well as pregnancy-associated thrombocytopenia.

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Section: Discussionsupporting

confidence: 93%

Section: Methodsmentioning

confidence: 99%

Section: Drugsmentioning

confidence: 99%

See 1 more Smart Citation

Possible Role of Platelet-Activating Factor in Embryonic Signaling during Oviductal Transport in the Hamster1

Velásquez

Aguilera

Croxatto³

1995

Biology of Reproduction

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“…When PGF-2a is administered i.p. to hamsters ovum transport is accelerated (Thomas, Bastiaans & Rolland, 1980). The relationship between oviducal tissue levels of PGF and ovum transport in rabbits has already been documented by Saksena & Harper (1975) and Rajkumar, Garg & Sharma (1979).…”

Section: Introductionmentioning

confidence: 75%