Effects of prostaglandin F2α prostaglandin E2 and arachidonic acid on the induction of oviposition in vivo and in vitro in oviparous lizards

Guillette, Louis J.; Masson, Greg R.; DeMarco, Vincent G.

doi:10.1016/0090-6980(91)90015-8

Cited by 10 publications

(4 citation statements)

References 18 publications

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“…S10). Hormones of another family, PGs, increase in concentrations in plasma at the time of oviposition or birth, and are associated with the onset of labor in eutherian mammals, as well as uterine contraction in reptiles (43)(44)(45). PTGS2, the key enzyme for PG synthesis (50), was significantly up-regulated during all gestation stages compared with S1 in P. przewalskii (Fig.…”

Section: Resultsmentioning

confidence: 97%

“…The evolution of viviparity requires prolonged egg retention until embryogenesis is complete (13,14). Oviposition/ birth is accomplished through periodic muscle contraction, and several hormones are known to play a role in stimulating these contractions, especially the hormones arginine vasotocin (AVT) and prostaglandins (PGs) (43)(44)(45)(46). AVT is an oligopeptide that is homologous to oxytocin in placental mammals, where it promotes muscle contraction during parturition (47).…”

Section: Resultsmentioning

confidence: 99%

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Genomic and transcriptomic investigations of the evolutionary transition from oviparity to viviparity

Gao

Sun

Zhou

et al. 2019

Proc. Natl. Acad. Sci. U.S.A.

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Viviparous (live-bearing) vertebrates have evolved repeatedly within otherwise oviparous (egg-laying) clades. Over two-thirds of these changes in vertebrate reproductive parity mode happened in squamate reptiles, where the transition has happened between 98 and 129 times. The transition from oviparity to viviparity requires numerous physiological, morphological, and immunological changes to the female reproductive tract, including eggshell reduction, delayed oviposition, placental development for supply of water and nutrition to the embryo by the mother, enhanced gas exchange, and suppression of maternal immune rejection of the embryo. We performed genomic and transcriptomic analyses of a closely related oviparous–viviparous pair of lizards (Phrynocephalus przewalskii and Phrynocephalus vlangalii) to examine these transitions. Expression patterns of maternal oviduct through reproductive development of the egg and embryo differ markedly between the two species. We found changes in expression patterns of appropriate genes that account for each of the major aspects of the oviparity to viviparity transition. In addition, we compared the gene sequences in transcriptomes of four oviparous–viviparous pairs of lizards in different genera (Phrynocephalus, Eremias, Scincella, and Sphenomorphus) to look for possible gene convergence at the sequence level. We discovered low levels of convergence in both amino acid replacement and evolutionary rate shift. This suggests that most of the changes that produce the oviparity–viviparity transition are changes in gene expression, so occasional reversals to oviparity from viviparity may not be as difficult to achieve as has been previously suggested.

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Section: Resultsmentioning

confidence: 97%

Section: Resultsmentioning

confidence: 99%

Genomic and transcriptomic investigations of the evolutionary transition from oviparity to viviparity

Gao

Sun

Zhou

et al. 2019

Proc. Natl. Acad. Sci. U.S.A.

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“…PGF 2α can be produced directly from PGH 2 (Kabututu et al, 2009) or from PGE 2 (Phillips et al, 2011). PGF 2α induces oviposition in oviparous reptiles (Guillette Jr. et al, 1991;Hargrove and Ottinger, 1992;Kupittayanant et al, 2009), and elicits myometrial contractions during labor in viviparous mammals (Karim, 1968;Challis et al, 2000;McKeown et al, 2000). PGF 2α binds to the prostaglandin F receptor, whose activation leads to release of intracellular calcium which in turn binds calmodulin; calcium-calmodulin then activates myosin light chain kinase to phosphorylate myosin light chains and cause muscle contraction .…”

Section: Inflammation At Parturitionmentioning

confidence: 99%

Cooperative inflammation: The recruitment of inflammatory signaling in marsupial and eutherian pregnancy

Stadtmauer

Wagner

2020

Journal of Reproductive Immunology

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The evolution of viviparity in therian mammals, i.e. marsupials and "placental" mammals, occurred by retention of the conceptus in the female reproductive tract and precocious "hatching" from the shell coat. Both eutherian embryo implantation and the opossum embryo attachment reaction are evolutionarily derived from and homologous to a defensive inflammatory process induced after shell coat hatching. However, both lineages, marsupials and placental mammals, have modified the inflammatory response substantially. We review the induction, maintenance, and effects of inflammation throughout pregnancy, with special attention to the role of prostaglandins and the mucosal inflammatory response, both of which likely had roles in early mammalian viviparity. We propose that the key step was not only suppression of the inflammatory response after implantation in placental mammals, but also the transfer of the inflammatory cell-cell communication network to a different set of cell types than in generic inflammation. To support this conclusion we discuss evidence that pro-inflammatory signal production in the opossum is not limited to maternal cells, as expected in bona fide defensive inflammation, but also includes fetal tissues, in a process we term cooperative inflammation. The ways in which the inflammatory reaction was independently modified in these two lineages helps explain major life history differences between extant marsupials and eutherians.

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“…Indomethacin has been shown to inhibit ovarian prostaglandin synthesis in mammals (Espy, et al, 1982), birds (Shimada, et al, 1986), fish (Goetz, 1983), and reptiles (Guillette, et al, 1990). In lizards, indomethacin delays both parturition (Guillette, et al, 1991) and follicle stimulating hormone-induced ovulation (Jones, et al, 1990), but its effect on follicular growth is unknown. Due to their effective inhibition of key reproductive hormones, we hypothesized that slow-release implants of tamoxifen and indomethacin would inhibit reproductive activity in lizards effectively and reversibly, if so, these chemical treatments could provide a clinically valuable alternative to the limited options currently available for assuring reproductive inactivity (e.g., ovariosalpingectomy).…”

Section: Introductionmentioning

confidence: 99%

The Use of Hormone Antagonists to Inhibit Reproduction in the Lizard, Eublepharus macularius

DeNardo

Helminski

2001

Journal of Herpetological Medicine and Surgery

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With the increase in popularity of reptiles as personal pets, there is an increasing desire to inhibit reproduction and the associated, and often times undesirable, effects. In an attempt to develop a therapeutic treatment to induce a temporary inhibition of reproduction, we implanted time-released pellets of tamoxifen, an estrogen binding inhibitor, or indomethacin, a prostaglandin synthesis inhibitor, intracoelomically into leopard geckos, Eublepharis macularius. All females treated with either tamoxifen or indomethacin (n = 6 for each group) at the onset of the reproductive season failed to show any follicular yolk deposition for the duration of the 60-day life span of the pellets, whereas 15 of indomethacin treated females were completely inhibited for the entire reproductive season, but 50% of the females developed a generalized edema. Fifty percent of tamoxifen treated females showed some follicular vitellogenesis after the expiration of the pellet, but no female successfully laid a viable clutch. Treatment with tamoxifen during active vitellogenesis was ineffective at inhibiting further follicular growth or ovulation. Eight of nine tamoxifen females successfully reproduced in the year following treatment and their reproductive output (i.e., number of total clutches, number of fertile clutches) was similar to that of control females. These results suggest that tamoxifen may be a viable treatment to induce temporary reproductive inhibition in reptiles, and further study is warranted.

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Effects of prostaglandin F2α prostaglandin E2 and arachidonic acid on the induction of oviposition in vivo and in vitro in oviparous lizards

Cited by 10 publications

References 18 publications

Genomic and transcriptomic investigations of the evolutionary transition from oviparity to viviparity

Genomic and transcriptomic investigations of the evolutionary transition from oviparity to viviparity

Cooperative inflammation: The recruitment of inflammatory signaling in marsupial and eutherian pregnancy

The Use of Hormone Antagonists to Inhibit Reproduction in the Lizard, Eublepharus macularius

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