Effects of prostaglandin on ovarian steroid secretion and biosynthesis during pregnancy

Hr, Behrman; Yoshinaga, Kaoru; Wyman, Heather; Ro, Greep

doi:10.1152/ajplegacy.1971.221.1.189

Cited by 58 publications

(7 citation statements)

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“…The first phase of the preparations for parturition involves, we believe, the production of PGs (probably F2a) which rapidly terminate luteal function causing progesterone levels to fall rapidly and 20a-OH-P levels to rise. The luteal regression caused by exogenous PGF2a in early pregancy or pseudo¬ pregnancy in the rat has been shown to be accompanied by a rise in 20a-OH-P levels (Pharriss & Wyngarden, 1969;Behrman, Yoshinaga, Wyman & Greep, 1971). We believe that a second, oestrogen-dependent, phase of preparations is then initiated when progesterone falls below a critical level and the rising osetrogen levels attain a critical level.…”

Section: Discussionmentioning

confidence: 99%

Effects of Oestradiol and Prostaglandin F2 on the Timing of Parturition in the Rat

Dukes¹,

Chester²,

Atkinson³

1974

Reproduction

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Section: Discussionmentioning

confidence: 99%

Effects of Oestradiol and Prostaglandin F2 on the Timing of Parturition in the Rat

Dukes¹,

Chester²,

Atkinson³

1974

Reproduction

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“…In all groups the final concentration at delivery was the same as in the controls (Figs 2 and 3). This decrease in plasma progesterone concentration is probably caused by the shift from progesterone to 20a-hydroxypregn-4-en-3-one (20a-OHP) secretion observed both in pseudopregnant rats (Pharris & Wyngarden, 1969) and pregnant rats (Behrman, Yoshinaga, Wyman & Greep, 1971) treated with PGF2a. This change is similar to that observed during the later stages of normal pregnancy in the rat (Fajer & Barraclough, 1967;Weist, Kidwell & Balogh, 1968;Weist, 1970).…”

Section: Plasma Progesterone Concentrations In Pgf2a-infused Animalsmentioning

confidence: 99%

“…Oestrogens appear to be involved in the control of PGF2a synthesis in several different species (Blatchley, Donovan, Horton, Poyser, Thompson & Los, 1971;Liggins, Fairclough, Grieves, Kendall & Knox, 1973). It is also possible that PGF2a may stimulate ovarian oestrogen production (Behrman et al 1971). If this does occur it might constitute an elegant feedback system and would explain the observation that delivery was normal in PGF2a-infused rats (Buckle & Nathanielsz, 1973).…”

Section: Plasma Progesterone Concentrations In Pgf2a-infused Animalsmentioning

confidence: 99%

A COMPARISON OF THE CHARACTERISTICS OF PARTURITION INDUCED BY PROSTAGLANDIN F2α, INFUSED INTRA-AORTICALLY, WITH THOSE FOLLOWING OVARIECTOMY IN THE RAT

Buckle

Nathanielsz

1975

Journal of Endocrinology

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Prostaglandin F2alpha (PGF2alpha) was infused intra-aortically at different rates into rats for 11-5 h from day 18 of gestation. At doses in excess of 5 mug/h premature delivery invariably occ'rred 40-41 h later. At lower doses an all-or-none effect was observed, some animals delivering prematurely and others continuing to term. Parturition could not be induced earlier than 40 h after the start of the treatment even by a continuous infusion of PGF2alpha, suggesting that the luteolytic role of PGF2alpha is more important than its oxytocic action in this case. The rate of fall in plasma progesterone was greater in the rats delivering prematurely than those delivering at term, although the final concentrations of between 15 and 30 ng/ml at delivery were the same. Labour appeared more normal in the animals receiving PGF2alpha than in those which had been bilaterally ovariectomized. The possible significance of this in relation to an effect of PGF2alpha on oestrogen secretion is discussed.

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“…stimulates, whereas a high dose inhibits, progesterone synthesis-the inhibition being overcome by HCG. According to Behrman et al (1971), the fall in progesterone synthesis caused by a high dose of PGF2. may be due to loss of stored cholesterol ester, with eventual depletion of free cholesterol available for progesterone synthesis.…”

Section: Prostaglandins and Progesterone Productionmentioning

confidence: 99%

Prostaglandins in reproductive physiology

Craig

1975

Postgraduate Medical Journal

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SummaryThe role of prostaglandins in reproductive physiology is reviewed with particular emphasis on their possible importance in ovulation in humans. A possible interaction between gonadal steroids, biogenic amines and prostaglandins at hypothalamic-pituitary level, in relation to the release of luteinizing hormone releasing factor, and LH, is discussed. Anomalies regarding the role of oestrogens in LH release are noted, and it is suggested that high oestrogen levels may release prostaglandins from the uterus and/or centrally in humans, in connection with the mid-cycle LH surge and ovulation. A hypothetical role for prostaglandins in sexual behaviour and premenstrual changes is discussed.The hypotheses open up new areas for clinical research to establish the role of prostaglandins in human endocrinology. The need for measurement of prostaglandin metabolites in blood and urine is emphasized. IntroductionThe purpose of this article is to review the role of prostaglandins in reproductive physiology. Established knowledge is outlined briefly and used as a basis for speculative thought on certain aspects. No attempt is made to cover the field in exhaustive detail and pertinent observations may well have been inadvertently overlooked, as the background literature is vast. However, it is hoped that the overall picture given will help to clarify ideas on the subject and lead to further constructive discussion and research.The role of prostaglandins in fertilization and their effect on the uterus are mentioned briefly. Their effect on the ovary in relation to progesterone synthesis, luteolysis and ovulation are discussed in more detail.

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Effects of prostaglandin on ovarian steroid secretion and biosynthesis during pregnancy

Cited by 58 publications

References 0 publications

Effects of Oestradiol and Prostaglandin F2 on the Timing of Parturition in the Rat

Effects of Oestradiol and Prostaglandin F2 on the Timing of Parturition in the Rat

A COMPARISON OF THE CHARACTERISTICS OF PARTURITION INDUCED BY PROSTAGLANDIN F2α, INFUSED INTRA-AORTICALLY, WITH THOSE FOLLOWING OVARIECTOMY IN THE RAT

Prostaglandins in reproductive physiology

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