Effects of protein intake variation and omega-3 polyunsaturated fatty acids on renal function in chronic renal disease

Schaap, G.H.; Bilo, H. J. G.; Popp-Snijders, C.; Oe, P. L.; Mulder, Cees; Donker, A. J. M.

doi:10.1016/0024-3205(87)90469-3

Cited by 23 publications

(8 citation statements)

References 14 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…A lipid-lowering effect of fish oil supplementation has been observed in a number of studies investigating patients with essential hypertension and hyperlipidemia. A lowering of plasma triglyceride concentrations during fish oil intake has also been observed in patients with chronic renal insufficiency [2,32].…”

Section: Discussionmentioning

confidence: 99%

Different effects of eicosapentaenoic acid and olive oil on blood pressure, intracellular free platelet calcium, and plasma lipids in patients with essential hypertension

et al. 1993

View full text Add to dashboard Cite

In a randomized, double-blind, crossover study our specific aim was to examine the effects of a dietary fish oil or olive oil supplementation on blood pressure, intracellular free platelet calcium, plasma lipoproteins, and circulating vasoactive substances such as norepinephrine, epinephrine, and renin in patients with essential hypertension. Ten hypertensive patients (WHO classes I, II) were randomly assigned to receive 9 g fish oil or 9 g olive oil daily for 6 weeks after a 4-week baseline period. The 6-week treatment periods were separated by a 4-week wash-out. During treatment with fish oil diastolic blood pressure decreased from 103 +/- 1 to 98 +/- 2 mmHg (P < 0.05) but did not change significantly during olive oil intake. Systolic blood pressure was not affected by either treatment. Intracellular free platelet calcium decreased in patients receiving fish oil (from 102 +/- 8 nM to 86 +/- 6 nM, P < 0.05) but was not significantly altered by olive oil treatment. In contrast, the dose-response curve for thrombin-induced intracellular free platelet calcium was not altered by the fish oil enriched diet. Plasma triglycerides decreased by approximately 40% in the fish oil group while low-density lipoprotein cholesterol, high-density lipoprotein cholesterol, and total cholesterol were not altered. Renin activity, norepinephrine, and epinephrine in plasma were not influenced by fish oil supplementation. We conclude that a moderate increase in dietary fish oil reduces diastolic blood pressure, intracellular free platelet calcium, and plasma triglycerides in patients with essential hypertension.(ABSTRACT TRUNCATED AT 250 WORDS)

show abstract

Section: Discussionmentioning

confidence: 99%

Different effects of eicosapentaenoic acid and olive oil on blood pressure, intracellular free platelet calcium, and plasma lipids in patients with essential hypertension

et al. 1993

View full text Add to dashboard Cite

show abstract

“…Some studies are short term with follow-up periods of 8-12 weeks [81][82][83]. The combined results of these studies are shown in table 1.…”

Section: Influence On Renal Functionmentioning

confidence: 89%

“…[81][82][83] However, in quite a few studies in patients with CRI, total cholesterol levels rose, although certainly not al ways. When a rise was found, this apparently was due to a rise in LDL cholesterol levels.…”

Section: Influence On Lipid Profilementioning

confidence: 99%

See 1 more Smart Citation

Omega-3 Polyunsaturated Fatty Acids in Chronic Renal Insufficiency

Bilo

Gans

Donker³

1991

Nephron

Self Cite

View full text Add to dashboard Cite

“…In an initial study, (n-3) PUFA supplements were noted to preserve renal function in a group of patients with a variety of conditions resulting in chronic renal failure, including chronic glomerulonephritis, interstitial nephritis, glomerulosclerosis, chronic pyelonephritis and polycystic disease (97). Subsequent studies of patients with various chronic renal diseases failed to confirm this benefit and noted mixed effects on plasma lipid levels (98,99).…”

Section: Current Status Of the Use Of Dietary Fatty Acid Manipulationmentioning

confidence: 99%

Polyunsaturated Fatty Acids and Renal Disease

Lefkowith

Klahr

1996

Experimental Biology and Medicine

View full text Add to dashboard Cite

An upregulation of arachidonate metabolism often accompanies renal pathophysiologic states. The resulting eicosanoids contribute to, or modify, the underlying process. Recent investigations suggest that platelet-neutrophil interactions, as well as alterations in the expression of the inducible isoform of cyclooxygenase, play a critical role in mediating changes in arachidonate metabolism in renal inflammation. The importance of arachidonate to renal pathophysiology has been highlighted by prior investigations which have demonstrated a beneficial effect of dietary polyunsaturated fatty acid (PUFA) modulation in a variety of models of experimental renal disease. More recent work has established that this beneficial effect may depend upon alterations in both lipid mediator generation as well as changes in cell function. In light of the benefits of dietary PUFA modulation in models of experimental renal disease, there have been numerous recent clinical trials of dietary (n-3) PUFA supplementation in patients with a variety of renal disorders. These clinical trials suggest that such therapy may be an important addition to the clinical armamentarium, especially in the treatment of IgA nephropathy.

show abstract

Effects of protein intake variation and omega-3 polyunsaturated fatty acids on renal function in chronic renal disease

Cited by 23 publications

References 14 publications

Different effects of eicosapentaenoic acid and olive oil on blood pressure, intracellular free platelet calcium, and plasma lipids in patients with essential hypertension

Different effects of eicosapentaenoic acid and olive oil on blood pressure, intracellular free platelet calcium, and plasma lipids in patients with essential hypertension

Omega-3 Polyunsaturated Fatty Acids in Chronic Renal Insufficiency

Polyunsaturated Fatty Acids and Renal Disease

Contact Info

Product

Resources

About