Effects of protein kinase A and C inhibitors on follicular inhibin and activin during ovulation

Hua, VK; Fleming, SD; Illingworth, Peter

doi:10.1016/s1472-6483(10)60311-2

Cited by 9 publications

(4 citation statements)

References 41 publications

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“…On the other side, oocytes express ActRI and ActRII, suggesting their ability to respond to activin (51,110,155,188,328,392). In mouse preantral follicles matured in vitro, the meiotic resumption of the oocyte is associated with increased activin A secretion by the follicle (179). More importantly, exposure to activin A during in vitro maturation stimulates premeiotic oocytes to undergo germinal vesicle breakdown and reach the metaphase II in murine (371,494) as well as in primate species, including the human (5,6).…”

Section: Ovarymentioning

confidence: 99%

Activin A in Mammalian Physiology

Bloise

Ciarmela

Cruz

et al. 2019

Physiological Reviews

155

129

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Activins are dimeric glycoproteins belonging to the transforming growth factor beta superfamily and resulting from the assembly of two beta subunits, which may also be combined with alpha subunits to form inhibins. Activins were discovered in 1986 following the isolation of inhibins from porcine follicular fluid, and were characterized as ovarian hormones that stimulate follicle stimulating hormone (FSH) release by the pituitary gland. In particular, activin A was shown to be the isoform of greater physiological importance in humans. The current understanding of activin A surpasses the reproductive system and allows its classification as a hormone, a growth factor, and a cytokine. In more than 30 yr of intense research, activin A was localized in female and male reproductive organs but also in other organs and systems as diverse as the brain, liver, lung, bone, and gut. Moreover, its roles include embryonic differentiation, trophoblast invasion of the uterine wall in early pregnancy, and fetal/neonate brain protection in hypoxic conditions. It is now recognized that activin A overexpression may be either cytostatic or mitogenic, depending on the cell type, with important implications for tumor biology. Activin A also regulates bone formation and regeneration, enhances joint inflammation in rheumatoid arthritis, and triggers pathogenic mechanisms in the respiratory system. In this 30-yr review, we analyze the evidence for physiological roles of activin A and the potential use of activin agonists and antagonists as therapeutic agents.

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Section: Ovarymentioning

confidence: 99%

Activin A in Mammalian Physiology

Bloise

Ciarmela

Cruz

et al. 2019

Physiological Reviews

155

129

View full text Add to dashboard Cite

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“…It has been found that both INHβA and INHβB inhibit FSH secretion. The role of these inhibins in the regulation of feedback loops between the pituitary and ovary, as well as their influence on folliculogenesis, has been shown previously (Hua et al ., 2008 ; Myers et al ., 2009 ; Poon et al ., 2009 ).…”

Section: Introductionmentioning

confidence: 99%

Expression of INHβA and INHβB proteins in porcine oocytes cultured in vitro is dependent on the follicle size

Kempisty

Piotrowska

Rybska

et al. 2013

Zygote

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SummaryThe current study aimed to investigate differential expression of inhibin βA (INHβA) and inhibin βB (INHβB) in porcine oocytes before or after in vitro maturation (IVM) isolated from follicles of various sizes. Porcine oocytes isolated from large, medium and small follicles (40 from each) were used to study the INHβA and INHβB protein expression pattern using western blot analysis before or after 44 h of oocyte IVM. An increased expression of INHβA was found in oocytes collected from large and medium follicles compared with small follicles before or after IVM (P < 0.001, P < 0.05, respectively). Similarly, higher INHβB levels were observed in oocytes recovered from large follicles compared with small (P < 0.01). As INHβA and INHβB are expressed in both porcine follicular somatic cells and oocytes, it can be assumed that these transforming growth factor beta (TGFβ) superfamily factors are involved in the regulation of molecular bi-directional pathways during follicle and oocyte development, and can be recognized as markers of follicle and oocyte maturation. Moreover, the current study clearly demonstrated that inhibin expression is substantially associated with porcine follicle growth and development.

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“…In addition, Activin A stimulates the expression of estrogen receptors in mice [ 84 ]. Finally, in mice, the oocyte resumption of meiosis occurred concomitantly with an increase in activin A [ 85 ].…”

Section: From the Secondary Follicle To The Antral Folliclementioning

confidence: 99%

An Update on In Vitro Folliculogenesis: A New Technique for Post-Cancer Fertility

2022

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Introduction: Obtaining in vitro mature oocytes from ovarian tissue to preserve women's fertility is still a challenge. At present, there is a therapeutic deadlock for girls and women who need emergency fertility preservation in case of a high risk of ovary invasion by malignant cells. In such a case, ovarian tissue cannot be engrafted; an alternative could be in vitro folliculogenesis. Methods: This review focuses on the progress of in vitro folliculogenesis in humans. PubMed and Embase databases were used to search for original English-language articles. Results: The first phase of in vitro folliculogenesis is carried out in the original ovarian tissue. The addition of one (or more) initiation activator(s) is not essential but allows better yields and the use of a 3D culture system at this stage provides no added value. The second stage requires a mechanical and/or enzymatic isolation of the secondary follicles. The use of an activator and/or a 3D culture system is then necessary. Conclusion: The current results are promising but there is still a long way to go. Obtaining live births in large animals is an essential step in validating this in vitro folliculogenesis technique.

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Effects of protein kinase A and C inhibitors on follicular inhibin and activin during ovulation

Cited by 9 publications

References 41 publications

Activin A in Mammalian Physiology

Activin A in Mammalian Physiology

Expression of INHβA and INHβB proteins in porcine oocytes cultured in vitro is dependent on the follicle size

An Update on In Vitro Folliculogenesis: A New Technique for Post-Cancer Fertility

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