Effects of protocatechuic acid against cisplatin-induced neurotoxicity in rat brains: an experimental study

Mert, Handan; Kerem, Özge; Mıs, Leyla; Yıldırım, Serkan; Mert, Nihat

doi:10.1080/00207454.2022.2147430

Cited by 7 publications

(3 citation statements)

References 59 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…The lowest TAC and the highest TOS levels were found in the cisplatin group, and researchers have reported that cisplatin increases oxidative stress and causes antioxidant depletion. 10 In this research 25 and 50 mg/kg/day BPA also affected these parameters, a decrease in TAC and an increase in TOS were found which helps to elucidate the harmful effects of BPA on living organisms.…”

Section: Discussionmentioning

confidence: 59%

“…Activation of cytokines was first described in 1926, and it was reported that they are dissolved products secreted from leukocytes and affect the functions of the vessel wall. 10,11 Tumor necrosis factor (TNF)-α regulates immune functions and is a cytokine secreted from fat cells It is a 26 kDa transmembrane protein that exerts its effect through Type I and Type II TNF-α receptors. TNF-α has been found to increase with inflammation, host parasitic diseases, septic shock, obesity and insulin resistance, and rheumatoid arthritis.…”

mentioning

confidence: 99%

See 1 more Smart Citation

Effect of Bisphenol-A on Oxidative Status and Certain Inflammatory Markers in Rats: Experimental Study

ÇİBUK,

YILMAZ,

MERT

et al. 2023

Turkiye Klinikleri J Vet Sci

View full text Add to dashboard Cite

Bisphenol-A (BPA) is a public health concern due to its widespread use in the living world and consumer products. It aimed to study the effect of ingested BPA on oxidative status and certain inflammatory markers in rats. Material and Methods: In this study, 24 Wistar Albino rats were used, and divided into 4 groups (control, sham, BPA25, BPA50). While no application was made to the first of these groups, corn oil was given to the second group (sham). In the first of the experimental groups, BPA dissolved in corn oil was administered at 25 mg/kg/day, and in the second at 50 mg/kg/day by oral gavage for one month. At the end of the experiment, the animals were anesthetized. Blood samples were taken from the heart and the sera were separated. Total antioxidant capacity, the total oxidative state, tumor necrosis factor-alpha, interleukin (IL)-1 beta, and IL -6 levels were determined by enzyme-linked immunosorbent assay. Results: When BPA was administered in doses of 25-50 mg/kg/day, serum total antioxidant capacity levels significantly decreased, while an increase was seen in total oxidative status and Oxidative Stress Index reflects harmful effects of BPA. Furthermore, serum tumor necrosis factor-alpha, IL-1-beta, and IL-6 levels increased significantly (p≤0.05). Conclusion: These results suggest that BPA exposure induces inflammatory markers. BPA also may causes oxidative stress, not only by promoting the production of oxidative compounds but also by reducing antioxidant capacity compared to the control group. All these biochemical changes may lead to damage to macromolecules in the tissues of living organisms.

show abstract

Section: Discussionmentioning

confidence: 59%

mentioning

confidence: 99%

Effect of Bisphenol-A on Oxidative Status and Certain Inflammatory Markers in Rats: Experimental Study

ÇİBUK,

YILMAZ,

MERT

et al. 2023

Turkiye Klinikleri J Vet Sci

View full text Add to dashboard Cite

show abstract

“…Thus, it is common to find elevated levels of IL-1β and IL-18 in CNS infections, brain injuries, and neurodegenerative illnesses. 30 - 36 Also, these cytokines contribute to cognition, learning, and memory processes in addition to being crucial for physiological activities in the CNS. 6 By releasing more inflammatory mediators and DAMPs, pyroptosis contributes to the pathophysiology caused by inflammasomes.…”

Section: Nlrp3 Inflammasome Activation and Its Relationship With Neur...mentioning

confidence: 99%

Role of NLRP3 Inflammasomes in Neurodegenerative Diseases

Demirtas,

Mazlumoglu,

Palabiyik Yucelik

2024

The Eurasian Journal of Medicine

View full text Add to dashboard Cite

Large-scale neuronal degeneration in the human brain is a hallmark of neurodegenerative diseases. These diseases range in location and cause, but they all have neurodegenerative characteristics in common. Neurodegenerative diseases, which have almost no effective treatment options, tend to progress irreversibly and cause large socioeconomic and healthcare costs. In recent years, due to the increase in the elderly population, neurodegenerative diseases that have a risk factor with aging are becoming increasingly common. Evidence that neurodegenerative diseases, which have an important place in public health, may be caused by neuroinflammation, has led to comprehensive investigation of neurodegenerative diseases in this regard. Inflammasomes are innate immune system-associated multiproteins that regulate caspase-1 activation and induce inflammation. The NLRP3 inflammasome is the most researched inflammasome and also located in microglia, its activation mediates the maturation and secretion of the inflammatory cytokines interleukin-1beta (IL-1β) and IL-18, thus exerting its effects in the central nervous system. Within the scope of this review, experimental and human studies evaluating the role of NLRP3 inflammasome activation and the effects of its inhibition in neurodegenerative diseases frequently encountered in society have been compiled with studies from past to present.

show abstract

The protective effects of protocatechuic acid against natural and chemical toxicants: cellular and molecular mechanisms

Kelidari,

Abedi,

Hayes

et al. 2024

Naunyn-Schmiedeberg's Arch Pharmacol

View full text Add to dashboard Cite

Effects of protocatechuic acid against cisplatin-induced neurotoxicity in rat brains: an experimental study

Cited by 7 publications

References 59 publications

Effect of Bisphenol-A on Oxidative Status and Certain Inflammatory Markers in Rats: Experimental Study

Effect of Bisphenol-A on Oxidative Status and Certain Inflammatory Markers in Rats: Experimental Study

Role of NLRP3 Inflammasomes in Neurodegenerative Diseases

The protective effects of protocatechuic acid against natural and chemical toxicants: cellular and molecular mechanisms

Contact Info

Product

Resources

About