IntroductionIn Asia, many caregivers are culturally obliged to assume the role of taking care of individuals experiencing chronic schizophrenia, even as they grapple with stigma and compassion fatigue. Despite the significance of this phenomenon, the collective experiences of Asian caregivers remain poorly understood.AimTo synthesise qualitative evidence on the experiences of informal caregivers when caring for individuals with chronic schizophrenia in Asia.MethodsA search was conducted on seven databases for studies published between 2013 and 2023. The included studies were appraised using the Critical Appraisal Skills Program tool. Data extraction was based on the Joanna Briggs Institute (JBI) Qualitative Extraction Form. The data synthesis was based on the framework by Sandelowski and Barroso.ResultsOur review included the experiences of 1345 informal caregivers from 57 included studies. The analysis yielded the overarching theme of ‘Navigating Challenges, Forging Resilience’. Three themes were identified: (i) challenges in caregiving, (ii) lack of support and (iii) coping and resilience.DiscussionOur findings highlighted the Asian caregivers' stressors, particularly cultural and traditional factors, a facet often overlooked in the literature.Implications for PracticeMental healthcare practitioners must provide caregivers with comprehensive information. Anticipatory guidance is essential during the initial stages of the diagnosis. To negate geographical limitations, caregiver‐training sessions can be pre‐recorded and posted to online platforms. Finally, cultural and spiritual beliefs can be integrated into the treatment plans for individuals with schizophrenia in the community.Relevance StatementWithin the institutional setting, mental healthcare practitioners are encouraged to provide caregivers with comprehensible information or training in person and through written or online platforms, which can transcend geographical limitations. Anticipatory guidance is essential, especially during the initial stages of the diagnosis, when confusion and uncertainties are prevalent. Periodic home visits by mental healthcare practitioners can help ease caregivers' concerns and enhance their caregiving confidence. Finally, cultural and spiritual beliefs should be integrated into the treatment plans for individuals with schizophrenia in the community as it promotes cultural acceptability, encourages referrals to appropriate institutions and reduces the stigma of mental healthcare.