Effects of Psychotropic Drugs on Human Erection and Ejaculation

Rt, Segraves

doi:10.1001/archpsyc.1989.01810030081011

Cited by 247 publications

(109 citation statements)

References 157 publications

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“…Although 5AR inhibitors have been generally shown to have few untoward effects and to be well tolerated by patient, they have been shown to sporadically induce erectile dysfunction and gynecomastia (Wilton et al, 1996), which may in turn limit the medication compliance. Nevertheless, it is important to emphasize that these side effects are reportedly rare (Wilton et al, 1996;Wessells et al, 2003) and are also triggered by antipsychotic agents (Segraves, 1989;Macdonald et al, 2003).…”

Section: -A-reductase Inhibitors In Models Of Psychosis M Bortolato mentioning

confidence: 99%

Antipsychotic-Like Properties of 5-α-Reductase Inhibitors

Bortolato

Frau

Orrù

et al. 2008

Neuropsychopharmacol

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Recent evidence indicates that neuroactive steroids may participate in the pathogenesis of schizophrenia spectrum disorders, yet the mechanisms of this involvement are elusive. As 5-a-reductase (5AR) is the rate-limiting enzyme of one of the two major metabolic pathways in brain steroidogenesis, we investigated the effects of its blockade in several rat models of psychotic-like behavior. The 5AR inhibitor finasteride (FIN, 60 or 100 mg/kg, intraperitoneal, i.p.) dose-and time-dependently antagonized prepulse inhibition (PPI) deficits induced by apomorphine (APO, 0.25 mg/kg, subcutaneous, s.c.) and d-amphetamine (AMPH, 5 mg/kg, s.c.), in a manner analogous to haloperidol (HAL, 0.1 mg/kg, i.p.) and clozapine (CLO, 5 mg/kg, i.p.). Similar results were observed with the other 5AR inhibitors dutasteride (DUT, 40 or 80 mg/kg, i.p.) and SKF 105111 (30 mg/kg, i.p.). FIN (60 or 100 mg/kg, i.p.) also reduced hyperlocomotion induced by AMPH (1 or 3 mg/kg, s.c.) and attenuated stereotyped behaviors induced by APO (0.25 mg/kg, s.c.). Nevertheless, FIN (100 mg/kg, i.p.) did not reverse the PPI disruption induced by the N-methyl-d-aspartate receptor antagonist dizocilpine (0.1 mg/kg, s.c.). FIN (60-300 mg/kg, i.p.) induced no catalepsy in either the bar test or the paw test. Our results suggest that 5AR inhibitors elicit antipsychotic-like effects in animals and may be proposed as a putative novel target in the management of psychotic disorders.

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Section: -A-reductase Inhibitors In Models Of Psychosis M Bortolato mentioning

confidence: 99%

Antipsychotic-Like Properties of 5-α-Reductase Inhibitors

Bortolato

Frau

Orrù

et al. 2008

Neuropsychopharmacol

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“…because of the unclarified mechanism and systemic side effects. [5][6][7][8] Attempting to elucidate the etiologic bases of PE, we had investigated penile sensory threshold changes in patients with primary PE, and found that patients with PE…”

Section: The Bcrap Changesmentioning

confidence: 99%

“…[5][6][7][8] Recently, neurobiological studies have made it likely that PE is not only a psychological disorder but a neurobiological phenomenon.…”

Section: Introductionmentioning

confidence: 99%

Effects of Renewal SS-cream on the Bulbocavernosus Reflex (BCR) in Rabbits

Tian

Jin

et al. 2008

Chonnam Med J

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Renewal SS-cream is a topical agent modified from the original SS-cream which is effective in the treatment of premature ejaculation. In this study, the efficacy of renewal SS-cream on premature ejaculation caused by the bulbocavernosus reflex (BCR) was investigated in rabbits. Sixty male New Zealand white rabbits (weights: 2.5∼3.0 kg) were divided into 3 groups randomly. Either renewal or original SS-cream or placebo (provided by CJ Co. LTD) was topically applied to the glans penis of rabbits in a double-blind manner. The bulbocavernosus reflex (BCR) was elicited by electrical stimulation of the glans penis. The latency of BCR (BCRLT) and the amplitude of BCR (BCRAP) were recorded on an electrophysiograph (Poseidomn, Shanghai, China) before and at 10, 30 and 60 min after application of the test agents. Representative tracings of BCRLT and BCRAP were recorded and analyzed. The mean BCRLT values were significantly prolonged in post-application groups of SS-cream Ⓡ and renewal SS-cream Ⓡ , compared with those in pre-application and placebo groups (p＜0.05). There was no significant difference in efficacy between SS-cream Ⓡ and renewal SS-cream Ⓡ groups (p＞0.05). The mean BCRAP showed decreasing tendency following application of SS-cream Ⓡ and renewal SS-cream Ⓡ ; however, they were not significantly different (p＞0.05). Both of original SS-cream Ⓡ and renewal SS-cream Ⓡ prolonged the BCRLT after their application to the glans penis in rabbits. The results indicate that they have local desensitizing effects on the sensory receptors of the dorsal nerve of the glans penis and may help control the ejaculatory reflex in patients with premature ejaculation.

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“…37 Drug-induced priapism, which as suggested implies a medication-related phenomenon, represents another variant that has resulted from use of alpha-adrenergic antihypertensives, psychotropic agents, antidepressant medications, cocaine, and pharmacotherapeutic agents for erectile dysfunction. [42][43][44][45][46][47][48][49][50][51][52][53][54][55][56] The mechanism of action is contended to relate to peripheral and central signaling pathways stimulated by the offending drug that produce corporal smooth muscle relaxation.…”

Section: Abnormal Penile Blood Flowmentioning

confidence: 99%

Priapism pathophysiology: clues to prevention

Burnett

2003

Int J Impot Res

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Priapism, in which penile erection persists in the absence of sexual excitation, is an enigmatic yet devastating erectile disorder. Current endeavors to manage the disorder suffer from a poor fundamental knowledge of the etiology and pathogenesis of priapism. These endeavors have remained essentially reactive, which commonly fail to avert its pathological consequences of erectile tissue damage and erectile disability, not to mention its psychological toll. The role of preventative management seems paramount with respect to priapism. As a prerequisite to formulating prevention strategies, gaining understanding of its pathogenic features and likely pathophysiologic mechanisms is viewed to be quite important. This review combined an analysis of clinicopathologic reports as well as a summary of clinical and basic science investigations on the subject to date. These assessments support the basic classification of priapism into low-flow (ischemic) and high-flow (nonischemic) hemodynamic categories, resulting from venous outflow occlusion and unregulated arterial overflow of the penis, respectively. In addition, consistent with the hypothesis that dysregulative physiology of penile erection accounts for some presentations of priapism, several plausible molecular mechanisms influencing the functional state of the erectile tissue are discussed. Current progress in the field suggests prevention possibilities using androgenic suppressive therapy, adrenergic agonist therapies, and effectors of the nitric oxide-dependent erection regulatory pathway in the penis. New ideas for prevention may emerge from targeting molecular mechanisms involved in regulating erectile tissue function.

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Effects of Psychotropic Drugs on Human Erection and Ejaculation

Cited by 247 publications

References 157 publications

Antipsychotic-Like Properties of 5-α-Reductase Inhibitors

Antipsychotic-Like Properties of 5-α-Reductase Inhibitors

Effects of Renewal SS-cream on the Bulbocavernosus Reflex (BCR) in Rabbits

Priapism pathophysiology: clues to prevention

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