Effects of PTH on osteoblast bioenergetics in response to glucose

DeMambro, Victoria; Tian, Li; Karthik, Vivin; Rosen, Clifford J.; Guntur, Anyonya R.

doi:10.1016/j.bonr.2023.101705

Bone Reports

2023

DOI: 10.1016/j.bonr.2023.101705

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Effects of PTH on osteoblast bioenergetics in response to glucose

Victoria DeMambro

Li Tian

Vivin Karthik

et al.

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2024

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Bone metabolism – an underappreciated player

Choi,

Umemoto,

Mizuno

et al. 2024

npj Metab Health Dis

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Bone is constantly being remodeled, and this process is orchestrated by a dynamic crosstalk of bone cells, including osteoclasts, osteoblasts, and osteocytes. Recent evidence suggests that cellular metabolism plays a crucial role in the differentiation and function of bone cells and facilitates the adaptation of bone cells to changes in the bone microenvironment. Moreover, bone affects whole-body energy metabolism. However, it is not yet completely understood how different cells in bone coordinate metabolic processes under physiological conditions, and how altered metabolic processes in bone cells contribute to pathological conditions where the balance among bone cells is disrupted. Therefore, gaining a better understanding of the distinct metabolic requirements of bone cells can provide crucial insights into the dysfunction of bone cells in pathological conditions and can be used to identify new therapeutic approaches to treat bone diseases. Here, we discuss recent advances in understanding metabolic reprogramming in bone cells.

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Bone metabolism – an underappreciated player

Choi,

Umemoto,

Mizuno

et al. 2024

npj Metab Health Dis

View full text Add to dashboard Cite

show abstract

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Effects of PTH on osteoblast bioenergetics in response to glucose

Cited by 1 publication

References 50 publications

Bone metabolism – an underappreciated player

Bone metabolism – an underappreciated player

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