Effects of purified polymannuronate on the performance, immune status, antioxidant capacity, intestinal microbial populations and volatile fatty acid concentrations of weaned piglets

Zhu, Wenhui; Li, D.F.; Wang, Hua; Li, J.T.; Chen, Y.Q.; Guan, Huashi; Zhang, L.Y.

doi:10.1016/j.anifeedsci.2015.05.015

Cited by 9 publications

(3 citation statements)

References 31 publications

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“…These results indicated the capacity of AOS to stimulate SCFA production in a donor-dependent manner, although SCFA levels were often lower than those found in the fermentation with inulin. These results were in agreement with previous studies carried out in vitro using human GM inoculum [18], as well as some in vivo studies performed in weaned pigs and broiler chickens [34,35], which indicate that AOS may have prebiotic potential.…”

Section: Discussionsupporting

confidence: 93%

Modulating the Gut Microbiota with Alginate Oligosaccharides In Vitro

et al. 2022

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Alginate oligosaccharides (AOS) are non-digestible carbohydrates from brown kelp. As such, they are dietary fibers and may have prebiotic potential. Therefore, we investigated the capacity of gut bacteria to utilize AOS with single-strain cultures and as a complex bacterial community. Bifidobacterium adolescentis, Lacticaseibacillus casei and Lacticaseibacillus paracasei showed weak growth (relative to unsupplemented medium; p < 0.05) in the presence of AOS and alginate, while strong growth (p < 0.01) was observed for Bacteroides ovatus when grown with alginate as carbohydrate source. Enterococcus faecium and Enterococcus hirae were for the first time reported to be able to grow on AOS. Further, AOS as substrate was investigated in a complex bacterial community with colonic fermentations in an in vitro gut model. The in vitro gut model indicated that AOS increased short-chain fatty acid (SCFA) levels in donors with a low endogenous SCFA production, but not to the same level as inulin. Bacteroides was found to dominate the bacteria community after in vitro gut simulation with alginate as substrate. Further, stimulation of Bacteroides was observed with AOS in the gut model for two out of three donors with the third donor being more resistant to change. Our results allowed the identification of AOS utilizers among common gut species. The results also demonstrated the capacity of AOS to elevate SCFA levels and positively modulate the gut microbiota during in vitro simulated colon fermentations, although some subjects appear to be resilient to perturbation via substrate changes.

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Section: Discussionsupporting

confidence: 93%

Modulating the Gut Microbiota with Alginate Oligosaccharides In Vitro

et al. 2022

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“…PM is a type of acidic polysaccharide that is derived from alginate and has antioxidant and anticoagulant activities. , Selenium, an essential trace element, is closely associated with the normal activities of life because of its role in an antioxidant enzyme . Although selenosis toxicity in humans is very rare, endemic selenium toxicity in some parts of China still exists, and selenosis from industrial accidents also happens occasionally because of inhalation.…”

Section: Discussionmentioning

confidence: 99%

Elucidation of the Molecular-Mechanisms and In Vivo Evaluation of the Anti-inflammatory Effect of Alginate-Derived Seleno-polymannuronate

Lai

Cai

et al. 2018

J. Agric. Food Chem.

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Alginate-derived polymannuronate (PM) is a type of polysaccharide found in edible brown seaweeds. Seleno-polymannuronate (Se-PM) was prepared from PM via synthesis using sulfation- and selenation-replacement reactions. The anti-inflammatory activity of Se-PM and its corresponding molecular mechanisms were investigated. In lipopolysaccharide (LPS)-activated murine macrophage RAW264.7 cells, Se-PM significantly attenuated the production of nitric oxide (NO), prostaglandin E (PGE), and reactive oxygen species (ROS); the expression of inducible nitric oxide synthase (iNOS) and cyclooxygenase-2 (COX-2); and the secretion of proinflammatory cytokines. Moreover, Se-PM remarkably suppressed the LPS-induced activation of the nuclear-factor (NF)-κB and mitogen-activated-protein-kinase (MAPK) signaling pathways in RAW264.7 cells. Furthermore, Se-PM also decreased the production of proinflammatory mediators in LPS-triggered primary murine macrophages. Additionally, Se-PM inhibited the inflammatory response in the air-pouch inflammation model. These results might contribute to the overall understanding of the potential health benefits of Se-PM for food and drug applications.

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“…Dietary changes including changes in diet composition ( Liu et al., 2018 ; Yu et al., 2019 ; Zhou et al., 2016 ), nutritional levels ( Lin et al., 2019 ), energy resources ( Papadomichelakis et al., 2012 ), and diet types ( Huang et al., 2020 ) had been widely proven to shape the gut microbiota communities. Antibiotics ( Schweer et al., 2017 ), prebiotics ( Tian et al., 2019 ; Zhu et al., 2016 ), probiotics ( Cao et al., 2016 ; Lv et al., 2015 ), organic acids ( Wang et al., 2019a ; Yu et al., 2017 ), essential oils ( Li et al., 2018 ), lactoferrin ( Hu et al, 2020 ), and milk-replacer may also regulate the gut microbiota communities and thus exert beneficial effects on piglets. In addition, other intervention approaches (e.g.…”

Section: Swine Gut Microbiota and Their Influencing Factorsmentioning

confidence: 99%

Swine gut microbiota and its interaction with host nutrient metabolism

Wang

Zhang

et al. 2020

Animal Nutrition

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Gut microbiota is generally recognized to play a crucial role in maintaining host health and metabolism. The correlation among gut microbiota, glycolipid metabolism, and metabolic diseases has been well reviewed in humans. However, the interplay between gut microbiota and host metabolism in swine remains incompletely understood. Given the limitation in conducting human experiments and the high similarity between swine and humans in terms of anatomy, physiology, polyphagy, habits, and metabolism and in terms of the composition of gut microbiota, there is a pressing need to summarize the knowledge gained regarding swine gut microbiota, its interplay with host metabolism, and the underlying mechanisms. This review aimed to outline the bidirectional regulation between gut microbiota and nutrient metabolism in swine and to emphasize the action mechanisms underlying the complex microbiome–host crosstalk via the gut microbiota–gut–brain axis. Moreover, it highlights the new advances in knowledge of the diurnal rhythmicity of gut microbiota. A better understanding of these aspects can not only shed light on healthy and efficient pork production but also promote our knowledge on the associations between gut microbiota and the microbiome–host crosstalk mechanism. More importantly, knowledge on microbiota, host health and metabolism facilitates the development of a precise intervention therapy targeting the gut microbiota.

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Effects of purified polymannuronate on the performance, immune status, antioxidant capacity, intestinal microbial populations and volatile fatty acid concentrations of weaned piglets

Cited by 9 publications

References 31 publications

Modulating the Gut Microbiota with Alginate Oligosaccharides In Vitro

Modulating the Gut Microbiota with Alginate Oligosaccharides In Vitro

Elucidation of the Molecular-Mechanisms and In Vivo Evaluation of the Anti-inflammatory Effect of Alginate-Derived Seleno-polymannuronate

Swine gut microbiota and its interaction with host nutrient metabolism

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