Effects of puromycin on memory for shuttle box extinction in goldfish and barpress extinction in rats

Braud, William G.; Broussard, William

doi:10.1016/0091-3057(73)90028-2

Cited by 12 publications

(4 citation statements)

References 14 publications

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“…A similar amount of puromycin given 1-2 hours following Trial 20 had no effect (Agranoff, 1968(Agranoff, , 1970Agranoff, Davis, & Brink, 196S, 1966;Davis, 1968;Davis, Bright, & Agranoff, 1965). Similar results were obtained by Braud and Broussard (1973) in the shuttle box paradigm with goldfish. They demonstrated that delayed injections of puromycin had no effect on retention of acquisition.…”

Section: Puromyclnmentioning

confidence: 65%

“…(These animals showed normal acquisition at a time when inhibition of cerebral protein synthesis was maximal.) Finally, in a recent study using rats, Braud and Broussard (1973) demonstrated that injection of puromycin immediately after a first extinction session depresses retention of extinction for bar pressing on subsequent extinction sessions. Mayor (1969aMayor ( , 1969b) investigated the puromycin effect in the Japanese quail.…”

Section: Puromyclnmentioning

confidence: 98%

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Antibiotics and memory.

Barraco¹,

Stettner²

1976

Psychological Bulletin

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Antibiotics have been investigated as potential amnesic agents in different species using a variety of learning paradigms. The initial interest in antibiotics as amnesic agents stemmed from their effects on protein synthesis; they were viewed as an avenue for exploring various hypotheses concerning the role of protein synthesis in memory formation. The major classes of antibiotics used in investigations of this type exert effects on protein synthesis through different mechanisms and may have other biochemical effects as well. They also appear to have different amnesic effects. The glutarimides (cycloheximide and acetoxycycloheximide) are generally effective in producing retention deficits only when injected prior to initial training. Puromycin, on the other hand, appears to be consistently effective when injected intracerebrally 24 hours after training. The effects of actinomycin-D appear to be inconsistent. Close examination of the literature indicates that all of these antibiotics have "side effects" which should be an important caution to experimenters, but that sufficient control procedures have been used in a variety of experiments to justify an amnesic interpretation of antibiotic-induced deficits on retention tests. The data further suggest that antibiotic-induced amnesia is reversible by chemical or behavioral means, with the possible exception of the case in which puromycin is injected prior to learning. An intensive review of the studies relevant to the neurochemical effects of the major antibiotics suggests that protein synthesis per se is not the crucial correlate of their behavioral effects. There are probably different modes of chemical action corresponding to the different behavioral effects. Several possible mechanisms are discussed in detail, most notably glutarimide effects on neurotransmitter activity and the relationship of puromycin to brain peptides.

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Section: Puromyclnmentioning

confidence: 65%

Section: Puromyclnmentioning

confidence: 98%

Antibiotics and memory.

Barraco¹,

Stettner²

1976

Psychological Bulletin

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“…could reasonably be argued that the performance improvement is in fact an additionally acquired experience that strengthens a weak, residual memory (Figure 3b and Figure 4). The first demonstration that reminders might strengthen an existing residual trace came in 1973 (Braud & Broussard 1973, Cherkin 1972, Gold et al 1973. The insight came from the understanding that, following amnesia treatments, the memory trace is rarely totally removed.…”

Section: Figurementioning

confidence: 99%

Impairments to Consolidation, Reconsolidation, and Long-Term Memory Maintenance Lead to Memory Erasure

Haubrich

Bernabo

Baker

et al. 2020

Annu. Rev. Neurosci.

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An enduring problem in neuroscience is determining whether cases of amnesia result from eradication of the memory trace (storage impairment) or if the trace is present but inaccessible (retrieval impairment). The most direct approach to resolving this question is to quantify changes in the brain mechanisms of long-term memory (BM-LTM). This approach argues that if the amnesia is due to a retrieval failure, BM-LTM should remain at levels comparable to trained, unimpaired animals. Conversely, if memories are erased, BM-LTM should be reduced to resemble untrained levels. Here we review the use of BM-LTM in a number of studies that induced amnesia by targeting memory maintenance or reconsolidation. The literature strongly suggests that such amnesia is due to storage rather than retrieval impairments. We also describe the shortcomings of the purely behavioral protocol that purports to show recovery from amnesia as a method of understanding the nature of amnesia.

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“…Not only is initial learning independent of protein synthesis, but the effects of the PSIs on later retention cannot be explained by any effect of these drugs on initial learning. Posttraining treatments have been shown to impair long-term memory in several different species and for a variety of tasks, even though the drug is not active during training (Agranoff, Davis, & Brink, 1966;Braud & Broussard, 1973;Davis, Rosenzweig, Kinkade, & Bennett, 1981;Geller et al, 1969;Gibbs & Ng, 1977;Neale et al, 1973;Oliver et al, 1979;Stettner, Barraco, Klauenberg, & Normile, 1979;Stettner, Barraco, & Normile, 1977). In addition, the drug is most effective when given immediately after learning and less effective when given at progressively longer intervals after training.…”

Section: Posttraining Drug Injectionsmentioning

confidence: 99%

Protein synthesis and memory: A review.

Davis¹,

Squire²

1984

Psychological Bulletin

1,378

893

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The hypothesis that memory depends in part on de novo brain protein synthesis has stimulated hundreds of experimental studies during the past 20 years involving drugs that reversibly inhibit brain protein synthesis. This article reviews those studies. It summarizes the basic findings, considers what stage of memory storage or retrieval is disrupted by the drugs, and reviews the side effects that these drugs have, including their effects on brain catecholamine metabolism. It is concluded that the available data make a compelling and internally consistent case for the hypothesis that protein synthesis, during or shortly after training, is an essential step in the formation of long-term memory.

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Effects of puromycin on memory for shuttle box extinction in goldfish and barpress extinction in rats

Cited by 12 publications

References 14 publications

Antibiotics and memory.

Antibiotics and memory.

Impairments to Consolidation, Reconsolidation, and Long-Term Memory Maintenance Lead to Memory Erasure

Protein synthesis and memory: A review.

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