1974
DOI: 10.1007/bf01856404
|View full text |Cite
|
Sign up to set email alerts
|

Effects of pyrazole on ethanol-induced changes in hepatic triglyceride and glycerol-1-phosphate contents and on esterified and non-esterified fatty acids in the blood

Abstract: Summary.Within 2 hrs after a single dose of 4 mg/g ethanol i.v. the glycerol-lphosphate content, the glycerol-l-phosphate/dihydroxyacetone phosphate ratio and the triglyceride content of the liver of mice rises significantly. At the same time the non-esterified fatty acids in the blood are slightly elevated and the esterified fatty acids in the blood slightly decreased. 340 ~g/g pyrazole i.p., which completely prevent the degradation of ethanol, prevent also the increase of the glycerol-l-phosphate content and… Show more

Help me understand this report

Search citation statements

Order By: Relevance

Paper Sections

Select...
2
1
1

Citation Types

0
4
0

Year Published

1975
1975
1994
1994

Publication Types

Select...
6
2

Relationship

0
8

Authors

Journals

citations
Cited by 12 publications
(4 citation statements)
references
References 30 publications
0
4
0
Order By: Relevance
“…An increased concentration of glycerol phosphate that accompanies the change in the redox state may be one of these (Nikkila & Ojala, 1963;Hawkins & Kalant, 1972;Lieber, 1974). However, glycerol phosphate concentrations alone cannot account for the ethanol-induced stimulation of triacylglycerol synthesis Fellenius et al, 1973;Estler, 1974;Abrams & Cooper, 1976a). The increased uptake of fatty acids from the circulation appears to be far more important (Bode & Goebell, 1971;Johnson et al, 1975;Abrams & Cooper, 1976a,b).…”
Section: Resultsmentioning
confidence: 99%
See 1 more Smart Citation
“…An increased concentration of glycerol phosphate that accompanies the change in the redox state may be one of these (Nikkila & Ojala, 1963;Hawkins & Kalant, 1972;Lieber, 1974). However, glycerol phosphate concentrations alone cannot account for the ethanol-induced stimulation of triacylglycerol synthesis Fellenius et al, 1973;Estler, 1974;Abrams & Cooper, 1976a). The increased uptake of fatty acids from the circulation appears to be far more important (Bode & Goebell, 1971;Johnson et al, 1975;Abrams & Cooper, 1976a,b).…”
Section: Resultsmentioning
confidence: 99%
“…Specific activity Enzyme activity (I) Control + (II) Control + glucose (7) ethanol (8) (III) Benfluorex (IV) Benfluorex + ethanol (7) + glucose (7) There is evidence that ethanol directly stimulates hepatic triacylglycerol synthesis (Beauge et al, 1972;Estler, 1974;Abrams & Cooper, 1976a). Liver homogenates obtained from rats treated 16h previously with ethanol are known to exhibit enhanced triacylglycerol synthesis (Scheig & Isselbacher, 1965).…”
Section: Resultsmentioning
confidence: 99%
“…Feeding sorbitol, glycerol and ethanol should also change the redox state of the liver (Hawkins & Kalant, 1972), whereas feeding fructose would not (Pereira & Jangaard, 1971). However, doubts have been expressed that changes in glycerol phosphate concentrations alone can account for the ethanol-induced stimulation of triacylglycerol synthesis (Kalant et al, 1972;Fellenius et al, 1973;Estler, 1974;Abrams & Cooper, 1976). Also, the administration of benfluorex to rats before feeding ethanol partially prevented the increase in soluble phosphohydrolase activity , but it did not alter the rate of ethanol oxidation by the rats .…”
Section: Groupmentioning
confidence: 99%
“…Other work has demonstrated that ingestion of ethanol and isopropanol increases the rate of hepatic TG synthesis at the expense of phospholipid production (Scheig & Isselbacher, 1965;BeaugC, Clement & others, 1972;Abrams & Cooper, 1976). These authors and Estler (1974) suggested that the stimulation of TG synthesis and the steatosis result from a direct effect on glycerolipid synthesis rather than from changes in hepatic redox state.…”
Section: Discussionmentioning
confidence: 97%