Effects of quadriceps muscle neuromuscular electrical stimulation in living donor liver transplant recipients: phase-II single-blinded randomized controlled trial

Hanada, Masatoshi; Soyama, Akihiko; Hidaka, Masaaki; Nagura, Hiroki; Oikawa, Masayuki; Tsuji, Ayumi; Kasawara, Karina Tamy; Mathur, Sunita; Reid, W. Darlene; Takatsuki, Mitsuhisa; Eguchi, Susumu; Kozu, Ryo

doi:10.1177/0269215518821718

Cited by 14 publications

(14 citation statements)

References 31 publications

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“…Further research into postoperative protein intake and physical activity will be essential for setting up a proper and feasible protocol to prevent patients suffering muscle loss [37,40]. Furthermore, a promising idea might be the application of neuromuscular electrical stimulation to muscles to maintain muscle thickness after surgery [46]. In conclusion, the current study demonstrated that surgery-related loss of muscle quantity or quality is present in more than half of the patients after liver resection for CRLM.…”

Section: Discussionmentioning

confidence: 81%

Risk factors for surgery-related muscle quantity and muscle quality loss and their impact on outcome

et al. 2021

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Background Surgery-related loss of muscle quantity negatively affects postoperative outcomes. However, changes of muscle quality have not been fully investigated. A perioperative intervention targeting identified risk factors could improve postoperative outcome. This study investigated risk factors for surgery-related loss of muscle quantity and quality and outcomes after liver resection for colorectal liver metastasis (CRLM). Methods Data of patients diagnosed with CRLM who underwent liver resection between 2006 and 2016 were analysed. Muscle quantity (psoas muscle index [PMI]), and muscle quality, (average muscle radiation attenuation [AMA] of the psoas), were measured using computed tomography. Changes in PMI and AMA of psoas after surgery were assessed. Results A total of 128 patients were analysed; 67 (52%) had surgery-related loss of muscle quantity and 83 (65%) muscle quality loss. Chronic obstructive pulmonary disease (COPD) (P = 0.045) and diabetes (P = 0.003) were risk factors for surgery-related loss of muscle quantity. A higher age (P = 0.002), open resection (P = 0.003) and longer operation time (P = 0.033) were associated with muscle quality loss. Overall survival was lower in patients with both muscle quantity and quality loss compared to other categories (P = 0.049). The rate of postoperative complications was significantly higher in the group with surgery-related loss of muscle quality. Conclusions Risk factors for surgery-related muscle loss were identified. Overall survival was lowest in patients with both muscle quantity and quality loss. Complication rate was higher in patients with surgery-related loss of muscle quality.

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Section: Discussionmentioning

confidence: 81%

Risk factors for surgery-related muscle quantity and muscle quality loss and their impact on outcome

et al. 2021

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“…It has been reported that NMES improved muscle strength of the lower limb muscle group in seriously ill patients [26]. We have previously reported that NMES, combined with conventional physical therapy, significantly improved muscle mass in post-LDLT patients, as compared with physical therapy alone [15]. However, quadriceps muscle strength after LDLT was not sufficiently recovered, and ADL was not improved by this method.…”

Section: Discussionmentioning

confidence: 75%

“…NMES is a practical, passive therapy that can be safely applied to maintain quadriceps muscle mass in seriously ill patients [14]. We have previously reported that NMES, combined with conventional physical therapy, significantly improved muscle mass in post-LDLT patients, compared with physical therapy alone [15]. Furthermore, after LDLT, patients are frequently malnourished.…”

Section: Introductionmentioning

confidence: 99%

Comparative study of the effect of neuromuscular electrical stimulation and oral administration of branched-chain amino acid on preventing sarcopenia in patients after living-donor liver transplantation: study protocol for an open-label randomized controlled trial

Haraguchi

Ichinose

Miyaaki

et al. 2021

Trials

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Background Liver cirrhosis is the irreversible fibrosis of the liver and causes refractory ascites and hepatic encephalopathy, which might not respond to treatment. Living donor liver transplantation (LDLT) is an effective treatment for patients with cirrhosis. However, post-LDLT patients are prone to muscle atrophy and sarcopenia. Therefore, physiotherapy of post-LDLT patients is essential for preventing the progression of sarcopenia. Recently, rehabilitation using neuromuscular electrical stimulation (NMES) has been reported to be useful for preventing the progression of sarcopenia. Similarly, nutrition therapy is essential for post-LDLT patients because these patients frequently experience malnutrition. However, the effects of combined NMES and nutrition therapy on post-LDLT patients remain unknown. Methods/design This open-label, randomized, parallel-group study will compare the effects of combined therapy with NMES and branched-chain amino acids (BCAA) with those of NMES alone in patients with decompensated cirrhosis after LDLT. After LDLT, 50 patients with decompensated cirrhosis will be randomly assigned to receive NMES with BCAA or NMES without BCAA. The duration of the intervention will be 3 months. To analyze the change in skeletal muscle mass, InBody 770 body composition and body water analysis and ultrasonography will be performed before LDLT and 4 weeks and 12 weeks post-LDLT. The primary endpoint is changes in the skeletal muscle mass from baseline to 3 months. Important secondary endpoints are the changes in the skeletal muscle mass from baseline to 1 month and changes in the quadriceps strength from baseline to 1 month. Discussion The results of this study are expected to provide evidence regarding the effect of NMES combined with BCAA therapy on the skeletal muscle of post-LDLT patients. Trial registration Japan Registry of Clinical Research jRCTs071190051. Registered on February 26, 2020.

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“…Presence of malnutrition and sarcopenia among patients with BS may contribute to worse outcomes. 58 To mitigate the negative impacts of frailty, especially those due to sarcopenia, several studies demonstrated the effectiveness of physical training 59 or neuromuscular electrical stimulation 60 for recipients after LT. However, no reports yet demonstrate the impact of these pre-LT preparations as a part of the "prehabitation" program.…”

Section: Frailtymentioning

confidence: 99%

Abdominal Organ Transplantation: Noteworthy Literature in 2019

Romano

Vasisko

Zerillo

et al. 2020

Semin Cardiothorac Vasc Anesth

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In the year 2019, we identified and screened over 400 peer-reviewed publications on pancreatic transplantation, over 200 on intestinal transplantation, and over 1900 on kidney transplantation. The liver transplantation section focuses on and features selected articles among 70 clinical trials published in 2019. This review highlights noteworthy literature pertinent to anesthesiologists and critical care physicians caring for patients undergoing abdominal organ transplantation. We explore a broad range of topics, including risks for and prediction of perioperative complications, updated indications for transplantation, recommendations on perioperative management, including Enhanced Recovery After Surgery programs, and topics relevant to optimization of patient and graft outcomes and survival.

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Effects of quadriceps muscle neuromuscular electrical stimulation in living donor liver transplant recipients: phase-II single-blinded randomized controlled trial

Cited by 14 publications

References 31 publications

Risk factors for surgery-related muscle quantity and muscle quality loss and their impact on outcome

Risk factors for surgery-related muscle quantity and muscle quality loss and their impact on outcome

Comparative study of the effect of neuromuscular electrical stimulation and oral administration of branched-chain amino acid on preventing sarcopenia in patients after living-donor liver transplantation: study protocol for an open-label randomized controlled trial

Abdominal Organ Transplantation: Noteworthy Literature in 2019

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