Effects of quantum dots on the ROS amount of liver cancer stem cells

Li, Kunmeng; Xia, Chunhui; Wang, Baiqi; Chen, Hetao; Wang, Tong; He, Qian; Cao, Hailong; Wang, Yu

doi:10.1016/j.colsurfb.2017.04.019

Cited by 13 publications

(6 citation statements)

References 35 publications

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“…Liver cancer is a serious disease that threatens human health. Several studies have demonstrated that GPx has anticancer activities in liver cancer [ 10 , 17 , 18 ]. In this study, we evaluated the anticancer effects of 5P in H22 cells in vitro and in a mouse model in vivo.…”

Section: Discussionmentioning

confidence: 99%

The Small Glutathione Peroxidase Mimic 5P May Represent a New Strategy for the Treatment of Liver Cancer

et al. 2017

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Glutathione peroxidase (GPx) is an antioxidant protein containing selenium. Owing to the limitations of native GPx, considerable efforts have been made to develop GPx mimics. Here, a short 5-mer peptides (5P) was synthesized and characterized using matrix-assisted laser desorption ionization time-of-flight mass spectrometry. Enzyme coupled assays were used to evaluate GPx activity. The cell viability and apoptosis of H22 cells were tested, and mice bearing H22 cell-derived tumors were used to determine the effects of 5P on tumor inhibition. In comparison with other enzyme models, 5P provided a suitable substrate with proper catalytic site positions, resulting in enhanced catalytic activity. In our mouse model, 5P showed excellent inhibition of tumor growth and improved immunity. In summary, our findings demonstrated the design and synthesis of the small 5P molecule, which inhibited tumor growth and improved immunity. Notably, 5P could inhibit tumor growth without affecting normal growth. Based on these advantages, the novel mimic may have several clinical applications.

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Section: Discussionmentioning

confidence: 99%

The Small Glutathione Peroxidase Mimic 5P May Represent a New Strategy for the Treatment of Liver Cancer

et al. 2017

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“…Studies have identified oxidative stress as one of the toxicity mechanisms of QDs and cadmium-based QDs have been shown to cause excessive accumulation of ROS, indirectly triggering adverse outcomes. 302–305 CdTe QDs can trigger mitochondrial dysfunction in hepatocytes via ROS, leading to apoptosis, 306 and CdSe/ZnS QDs can lead to ROS accumulation, altered phagocytosis, and increased apoptosis in macrophages. 211 The excessive accumulation of ROS generated by QDs which can mediate not only the induction of apoptosis but also other forms of ROS-mediated cell death can also be triggered, such as autophagy, 307–312 inflammation, 201,203,216,313–316 pyroptosis, 203,214,316 necrosis, 317–319 and ferroptosis.…”

Section: Toxicity Mechanism Of Qdsmentioning

confidence: 99%

New insights into the safety assessment of quantum dots: potential release pathways, environmental transformations, and health risks

Liu

Ding

Pang

et al. 2022

Environ. Sci.: Nano

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“…The introduction of sensitizers may fail to produce enough ROS to kill CSCs. Li et al investigated the effects of exogenous nanomaterials on ROS levels in liver cancer cells and liver CSCs and found that although the ROS level in ordinary cancer cells increased, exogenous nanomaterials at the same concentration showed a disappointing and insufficient ROS level in CSCs, which ultimately facilitates cell proliferation and survival [120].…”

Section: Double-edged Sword Of the Ros Generation Strategy In Rtmentioning

confidence: 99%

Promoting Reactive Oxygen Species Generation: A Key Strategy in Nanosensitizer-Mediated Radiotherapy

Jia

Fan

et al. 2021

Nanomedicine (Lond.)

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The radiotherapy enhancement effect of numerous nanosensitizers is based on the excessive production of reactive oxygen species (ROS), and only a few systematic reviews have focused on the key strategy in nanosensitizer-mediated radiotherapy. To clarify the mechanism underlying this effect, it is necessary to understand the role of ROS in radiosensitization before clinical application. Thus, the source of ROS and their principle of tumor inhibition are first introduced. Then, nanomaterial-mediated ROS generation in radiotherapy is reviewed. The double-edged sword effect of ROS and the potential dangers they may pose to cancer patients are subsequently addressed. Finally, future perspectives regarding ROS-regulated nanosensitizer applications and development are discussed.

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Effects of quantum dots on the ROS amount of liver cancer stem cells

Cited by 13 publications

References 35 publications

The Small Glutathione Peroxidase Mimic 5P May Represent a New Strategy for the Treatment of Liver Cancer

The Small Glutathione Peroxidase Mimic 5P May Represent a New Strategy for the Treatment of Liver Cancer

New insights into the safety assessment of quantum dots: potential release pathways, environmental transformations, and health risks

Promoting Reactive Oxygen Species Generation: A Key Strategy in Nanosensitizer-Mediated Radiotherapy

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