Effects of Quartz and Asbestos on Alveolar Macrophages: Interspecies Comparison and Cell Biological Studies

Seidel, A.; Nieder, U.; Pätzold, S.; Schimmelpfeng, Jutta; Schmidt, Angela; Wilczek, W.

doi:10.1007/978-3-642-46712-7_46

Cited by 3 publications

(1 citation statement)

References 3 publications

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“…201 Thirdly, the same cell type isolated from different human or animal origins, has different susceptibilities to the cytotoxic effects of a particular mineral, implying species-specific variations in cell sensitivities to minerals. 205,212 Fourthly, the same mineral has different cytotoxic effects on different types of cells, indicating that some cell types are more susceptible to the toxic effects of a particular mineral. 206 Recent investigations have suggested that the cytotoxicity of minerals towards a variety of cell types tested is due to the formation of oxygen metabolites catalysed by the iron present in crocidolite, 202,206,207 as it is known that antioxidants and iron chelating agents can inhibit asbestos fibre-induced cytotoxicity.…”

Section: Cytotoxicitymentioning

confidence: 99%

The ability of mineral dusts and fibres to initiate lipid peroxidation. Part II: relationship to different particle-induced pathological effects

Gulumian

2000

Redox Report

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Exposure to pathogenic mineral dusts and fibres is associated with pulmonary changes including fibrosis and cancer. Investigations into aetiological mechanisms of these diseases have identified modifications in specific macromolecules as well as changes in certain early processes, which have preceded fibrosis and cancer. Peroxidation of lipids is one such modification, which is observed following exposure to mineral dusts and fibres. Their ability to initiate lipid peroxidation and the parameters that determine this ability have recently been reviewed. Part II of this review examines the relationship between the capacity of mineral dusts and fibres to initiate lipid peroxidation and a number of pathological changes they produce. The oxidative modification of polyunsaturated fatty acids is a major contributor to membrane damage in cells and has been implicated in a great variety of pathological processes. In most pathological conditions where an induction of lipid peroxidation is observed it is assumed to be the consequence of disease, without further establishing if the induction of lipid peroxidation may have preceded or accompanied the disease. In the great majority of instances, however, despite the difficulty in proving this association, a causal relationship between lipid peroxidation and disease cannot be ruled out.

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Section: Cytotoxicitymentioning

confidence: 99%

The ability of mineral dusts and fibres to initiate lipid peroxidation. Part II: relationship to different particle-induced pathological effects

Gulumian

2000

Redox Report

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HL-60-Cell derived Macrophages are resistant to Cytotoxic Effects of Quartz

Brückner-Nieder

Schmidt

Schimmelpfeng

et al. 1992

Environmental Hygiene III

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Cytotoxic effects of quartz and chrysotile asbestos: In vitro interspecies comparison with alveolar macrophages

Schimmelpfeng

Seidel²

1991

Journal of Toxicology and Environmental Health

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Cytotoxic effects of DQ12 quartz and chrysotile asbestos on alveolar macrophages of different animal species were compared in vitro. The type of cell reaction toward the cytotoxic dusts was always the same: a loss of cell viability (trypan blue dye exclusion test) was accompanied by the release of cytoplasmic and lysosomal enzymes. The extent of cellular destruction depended upon the amount of dust applied. In the range of 50-100 micrograms/ml quartz or chrysotile asbestos, species-specific variations were observed in the sensitivity of the cells. At this concentration alveolar macrophages of dogs, monkeys, and human patients were damaged to a greater extent than the cells from rats and cattle. Simultaneous incubation of the cells with quartz and L-alpha-dipalmitoyl lecithin resulted in a reduction of the cytotoxic quartz effect. The extent of the protective effect varied according to the species. In the case of chrysotile asbestos no reduction of the fibers cytotoxicity was observed in the presence of L-alpha-dipalmitoyl lecithin.

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Effects of Quartz and Asbestos on Alveolar Macrophages: Interspecies Comparison and Cell Biological Studies

Cited by 3 publications

References 3 publications

The ability of mineral dusts and fibres to initiate lipid peroxidation. Part II: relationship to different particle-induced pathological effects

The ability of mineral dusts and fibres to initiate lipid peroxidation. Part II: relationship to different particle-induced pathological effects

HL-60-Cell derived Macrophages are resistant to Cytotoxic Effects of Quartz

Cytotoxic effects of quartz and chrysotile asbestos: In vitro interspecies comparison with alveolar macrophages

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