Effects of Quercetin Administration on the Pregnancy Outcome of Diabetic Rats

Braga, Camila Pereira; Baptista, Rafaela de Fátima Ferreira; Peixoto, Fernando Barbosa

doi:10.4172/2155-6156.1000180

Cited by 5 publications

(5 citation statements)

References 22 publications

(23 reference statements)

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“…Another study indicated that quercetin might have an antioxidant effect and prevented the renal tubular damage and decreased oxidative stress arising from induced by chronic cadmium administration (41). The treatment with quercetin in diabetic rats causes an increased number of corpora lutea and maternal weight gain (23).…”

Section: Discussionmentioning

confidence: 99%

“…The treatment with quercetin in diabetic rats causes an increased number of corpora lutea and maternal weight gain (23). Quercetin is a potential drug with antidiabetic and anti-hyperglycemic functions mediated by changes in the levels of glucose, cholesterol, and triglycerides (41). The findings propose that quercetin therapy has protective efficacy in diabetes by regressive oxidative stress and the maintenance of pancreatic-cell integrity (42).…”

Section: Discussionmentioning

confidence: 99%

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Protective Effect of Quercetin on Morphological and Histometrical Changes of Placenta in Streptozotocin-Induced Diabetic Rat

Shamsi

Ranjbar

Mahabady

et al. 2019

Zahedan J Res Med Sci

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Background: Maternal diabetes is a metabolic disorder among pregnant mothers that increases the risk of developing growth disorders in the fetus and the placenta. Placental deformity and dysfunction were reported in some studies. These changes have been related to oxidative stress. Quercetin is a component of the flavonoids group that can be found in vegetables, fruits, tea, and herbal supplements and has anti-inflammatory, anti-bacterial, anti-oxidant, and anti-diabetic properties. Objectives: In this experimental study, prophylactic effect of quercetin was evaluated for structural changes of the placenta in diabetic rats. Methods: Twenty-four pregnant Wistar rats were divided equally into four groups, including control, quercetin, diabetic, and quercetin-treated diabetic groups. Diabetes was induced by streptozotocin injection (50 mg/kg/IV), then male rats for mating were put together with female rats. Quercetin was administered (75 mg/kg/gavage), on 0, 7, 14, and 20 days of gestation. On 20th gestation day, the rats from all groups were anesthetized and laparotomized, then the placenta tissue was harvested. In the following, tissue section was stained by H&E and were analyzed histologically. Results: The weight, thickness and diameter of placenta in the diabetic group were increased but there was no significant difference compared to the quercetin treatment. The mean of the labyrinth zone, the number of trophoblastic giant cells and glycogen cells increased in the diabetic group and quercetin significantly reduced these parameters in diabetic rats (P < 0.05). In addition, the mean of junctional zone decreased in the diabetic group, while quercetin increased it (P < 0.05). Conclusions: The results suggest that quercetin has a protective effect on cell proliferation and preservation of placental morphology in pregnant diabetic rats.

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Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

Protective Effect of Quercetin on Morphological and Histometrical Changes of Placenta in Streptozotocin-Induced Diabetic Rat

Shamsi

Ranjbar

Mahabady

et al. 2019

Zahedan J Res Med Sci

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show abstract

“…[99][100][101][102] Although the underlying chemopreventive and chemotherapeutic mechanisms are needed to be elucidated, flavonoids have been thoroughly investigated as to how they modulate various key elements in cellular signal transduction pathways and their effect on cell fate determination processes. [103][104][105] Most dietary flavonoids not only inhibit the growth of tumor cells but also promote cell differentiation by quenching oxidative stress and inflammatory response.…”

Section: Utilisation Of Nanomedicine In Varied Applications Of Flavonoidsmentioning

confidence: 99%

Flavonoids: A vital resource in healthcare and medicine

Rahaman¹,

Mondal²

2020

PPIJ

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There are many biological resources in nature that are essential in relation to health care. Due to their flexible health benefits documented in various epidemiological studies, there has been increasing interest in research on flavonoids from plant sources. Since flavonoids are directly related to human dietary ingredients and health, structure and function relationships need to be evaluated. Flavonoids bioavailability, metabolism, and biological activity depends on the composition, total number of hydroxyl groups, and functional group substitution regarding their nuclear structure. Fruits and vegetables, together with tea and wine, are the primary dietary sources of flavonoids for humans. This review article primarily focusses on demarcating the importance of flavonoids which shows many pharmacological actions by acting as anti-cancer, anti-oxidant, anti-hypertensive and anti-cholinesterase agents. These flavonoids had shown positive results in treatment of pregnancy induced disorders. We also tried to discuss few studies which proves the efficiency of flavonoids to treat COVID-19. They had also been proved to show greater potential in treatment of Neurodegenerative diseases. Nanomedicine also has a greater part to play in near future as it helps flavonoids show effective targeted drug delivery.

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“…In another study [106] it was observed that quercetin may inhibit proinflammatory cytokines production in pregnant mice, especially IL-6 and IL-8. Additionally, Braga et al [107] investigated the effects of quercetin on the maternal reproductive capacity and fetal and placental development in diabetic rats. They showed that quercetin did not improve reproductive capacity, neither fetal nor placental development; however quercetin controlled glucose levels and promoted weight gain compared to untreated diabetic rats.…”

Section: Quercetin Intake During Pregnancymentioning

confidence: 99%

“…Results of meta-analysis of clinical trials [43] have shown that the impact of quercetin on blood pressure was reported in a total of 7 trials (587 patients) with results revealing significant reductions in both systolic and diastolic blood pressure following quercetin supplementation at doses from 100 mg/day to 1000 mg/day from 4 to 10 weeks [93, 107, 133–137]. In summary, the randomized controlled trials show that a significant reduction in systolic and diastolic blood pressure may be expected with quercetin doses ≥500 mg/day and the effect is insignificant with doses <500 mg/day [43].…”

Section: Clinical Trials and Meta-analysismentioning

confidence: 99%

Pharmacological Effect of Quercetin in Hypertension and Its Potential Application in Pregnancy‐Induced Hypertension: Review of In Vitro, In Vivo, and Clinical Studies

Ożarowski

Mikołajczak

Kujawski

et al. 2018

Evidence-Based Complementary and Alternative Medicine

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Since improving maternal and child health is a public health priority worldwide, the main aim of treatment of hypertension in pregnant women is to prevent complications during pregnancy, labor, and postpartum. In consequence, much attention is paid to the use of antihypertensive drugs that can be used safely during pregnancy. Several side effects of methyldopa, which is currently the most commonly used antihypertensive drug in pregnant women, mean that the search for an effective and safe alternative still continues. Flavonoid compounds present in medicinal plants, vegetables, and fruits may be a promising source of new drugs. In this aspect, quercetin, a well-known flavonoid due to its antihypertensive action, may be considered a prototype for safe antihypertensive drugs. This review focuses on the selective activity of quercetin. Based on recent studies, a few problems were discussed, including (1) pathology of pregnancy-induced hypertension; (2) search for new pharmacological treatments of pregnancy-induced hypertension; (3) issues with the use of herbal extracts during pregnancy; (4) flavonoids as natural active chemical compounds; (5) quercetin: its action during pregnancy, in vitro and in vivo pharmacological activities, clinical trials, and meta-analysis; (6) quercetin intake during pregnancy; (7) other natural compounds tested during pregnancy; (8) potential problems with the use of quercetin; (9) safety profile of quercetin. Various studies have shown a beneficial effect of quercetin on vascular endothelial function and its antioxidative and anti-inflammatory activity on cellular and tissue level. It is known that in animal models quercetin affects positively the development of embryo, fetus, and placenta. Because this flavonoid did not have teratogenic and abortive effect, it is generally recognized as safe. For this reason it should be appreciated and studied in the aspect of its potential use in the prevention and treatment of pregnancy-induced hypertension among women in this risk group.

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Effects of Quercetin Administration on the Pregnancy Outcome of Diabetic Rats

Cited by 5 publications

References 22 publications

Protective Effect of Quercetin on Morphological and Histometrical Changes of Placenta in Streptozotocin-Induced Diabetic Rat

Protective Effect of Quercetin on Morphological and Histometrical Changes of Placenta in Streptozotocin-Induced Diabetic Rat

Flavonoids: A vital resource in healthcare and medicine

Pharmacological Effect of Quercetin in Hypertension and Its Potential Application in Pregnancy‐Induced Hypertension: Review of In Vitro, In Vivo, and Clinical Studies

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