Effects of Quercetin and Resveratrol on Zinc Chloride- and Sodium Metavanadate-Induced Passive Avoidance Memory Retention Deficits in Male Mice

Abstract

Quercetin and resveratrol are found in a variety of fruits and vegetables and have several biological and pharmacological properties. In this study, the effects of quercetin [50 mg/kg, intraperitoneal (i.p.)] and resveratrol (50 mg/kg, i.p.) on zinc chloride (ZnCl2; 75 mg/kg/d, 2 weeks oral gavage) and sodium metavanadate (SMV; 22.5 mg/kg/d, 2 weeks oral gavage) induced passive avoidance memory retention were investigated in step-through passive avoidance tasks. ZnCl2 was dissolved in saline and SMV was dissolved in drinking water. Mice received ZnCl2 or SMV orally for two weeks and were administered quercetin or resveratrol by i.p. injection on day 14, days 12 and 14, or days 10, 12, and 14. At the end of treatment, animals were trained for one day in a step-through passive avoidance task, then alterations in avoidance memory retention were evaluated after 24, 48, 96, and 168 h. Oral consumption of ZnCl2 and SMV decreased latency time compared with control groups. Both quercetin and resveratrol (50 mg/kg, i.p.) prevented ZnCl2-and SMV-induced avoidance memory retention impairments and did not significantly alter muscle strength, as demonstrated in rotarod tasks. No significant differences were observed between mice who received single, double, or triple doses of quercetin or resveratrol. The results suggest that quercetin and resveratrol may have preventive effects on ZnCl2-and SMV-induced memory impairment in male mice.

Resveratrol and 1,25-dihydroxyvitamin D decrease Lingo-1 levels, and improve behavior in harmaline-induced Essential tremor, suggesting potential therapeutic benefits

“…The activation of Sirt1 by VitD3 has been observed to also strengthen the neuronal synapse, cause a decrease in AChE activity, reduce oxidative stress, and downregulate NF-kB, TNF-α, and IL-1 79 – 83 . Our results indicate that Res significantly improves memory deficits in ET rats, which is in line with previous studies 84 , 85 , including those that showed that Res improved performance in the passive avoidance task in a model of Alzheimer’s disease. Res was believed to exert its beneficial effects on impairments in recognition memory by enhancing activity in cholinergic systems, increasing levels of BDNF, facilitating phosphorylation of cAMP response element binding protein (CREB) signaling pathways in the prefrontal cortex, inhibiting the production of inflammatory cytokines, and reducing oxidative stress 84 – 89 .…”

“…Our results indicate that Res significantly improves memory deficits in ET rats, which is in line with previous studies 84 , 85 , including those that showed that Res improved performance in the passive avoidance task in a model of Alzheimer’s disease. Res was believed to exert its beneficial effects on impairments in recognition memory by enhancing activity in cholinergic systems, increasing levels of BDNF, facilitating phosphorylation of cAMP response element binding protein (CREB) signaling pathways in the prefrontal cortex, inhibiting the production of inflammatory cytokines, and reducing oxidative stress 84 – 89 . Recent studies have shown that Sirt1 plays a key role in cognitive performance and regulation of memory function through modulation of BDNF and inhibition of glutamate and the glutamatergic NMDA receptors, which are important factors in the differentiation of hippocampal neuronal cells and synaptic plasticity 90 .…”

Sarcopenic Obesity: Involvement of Oxidative Stress and Beneficial Role of Antioxidant Flavonoids

“…Quercetin (3,3 ,4 ,5,7-pentahydroxyflavone) is a flavonol abundantly present in various vegetables and fruits [173]. It can protect against multiple diseases, such as osteoporosis, cancer, memory impairment, and cardiovascular diseases, and these promising effects are achieved partly through its antioxidant and anti-inflammatory actions [174][175][176][177]. Quercetin also has a positive influence on decreasing body weight and adiposity in diet-induced obese animals, and multiple mechanisms, such as the activation of lipolysis, inhibition of lipogenesis and adipogenesis, and browning effects, have been implicated in its antiobesity effects in vivo and in vitro [178][179][180][181][182][183][184].…”