Effects of Quercetin Glycoside Supplementation Combined With Low-Intensity Resistance Training on Muscle Quantity and Stiffness: A Randomized, Controlled Trial

Otsuka, Yuichi; Miyamoto, Naokazu; Nagai, Akitoshi; Izumo, Takayuki; Nakai, Michikazu; Fukuda, Masahiro; Arimitsu, Takuma; Yamada, Yosuke; Hashimoto, Takeshi

doi:10.3389/fnut.2022.912217

Cited by 7 publications

(6 citation statements)

References 41 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…These include potential roles in the treatment of cognitive function and cerebral blood flow [ 306 ] and modulation of the progression of AD [ 307 ] and CNS viral infection [ 308 ]. The efficacy of quercetin in muscle physiology has been evaluated [ 309 ] and its roles in the modulation of IGF-I and IGF-II levels following muscle damage [ 310 ]. Quercetin antioxidant effects have been examined in metabolic syndrome [ 311 ], and its efficacy in the treatment of blood pressure and endothelial dysfunction and regulation of lipid profiles and inflammatory biomarkers in metabolic syndrome [ 312 , 313 ].…”

Section: Flavonoid Clinical Trialsmentioning

confidence: 99%

The Potential of Flavonoids and Flavonoid Metabolites in the Treatment of Neurodegenerative Pathology in Disorders of Cognitive Decline

Melrose

2023

Antioxidants

View full text Add to dashboard Cite

Flavonoids are a biodiverse family of dietary compounds that have antioxidant, anti-inflammatory, antiviral, and antibacterial cell protective profiles. They have received considerable attention as potential therapeutic agents in biomedicine and have been widely used in traditional complimentary medicine for generations. Such complimentary medical herbal formulations are extremely complex mixtures of many pharmacologically active compounds that provide a therapeutic outcome through a network pharmacological effects of considerable complexity. Methods are emerging to determine the active components used in complimentary medicine and their therapeutic targets and to decipher the complexities of how network pharmacology provides such therapeutic effects. The gut microbiome has important roles to play in the generation of bioactive flavonoid metabolites retaining or exceeding the antioxidative and anti-inflammatory properties of the intact flavonoid and, in some cases, new antitumor and antineurodegenerative bioactivities. Certain food items have been identified with high prebiotic profiles suggesting that neutraceutical supplementation may be beneficially employed to preserve a healthy population of bacterial symbiont species and minimize the establishment of harmful pathogenic organisms. Gut health is an important consideration effecting the overall health and wellbeing of linked organ systems. Bioconversion of dietary flavonoid components in the gut generates therapeutic metabolites that can also be transported by the vagus nerve and systemic circulation to brain cell populations to exert a beneficial effect. This is particularly important in a number of neurological disorders (autism, bipolar disorder, AD, PD) characterized by effects on moods, resulting in depression and anxiety, impaired motor function, and long-term cognitive decline. Native flavonoids have many beneficial properties in the alleviation of inflammation in tissues, however, concerns have been raised that therapeutic levels of flavonoids may not be achieved, thus allowing them to display optimal therapeutic effects. Dietary manipulation and vagal stimulation have both yielded beneficial responses in the treatment of autism spectrum disorders, depression, and anxiety, establishing the vagal nerve as a route of communication in the gut-brain axis with established roles in disease intervention. While a number of native flavonoids are beneficial in the treatment of neurological disorders and are known to penetrate the blood–brain barrier, microbiome-generated flavonoid metabolites (e.g., protocatechuic acid, urolithins, γ-valerolactones), which retain the antioxidant and anti-inflammatory potency of the native flavonoid in addition to bioactive properties that promote mitochondrial health and cerebrovascular microcapillary function, should also be considered as potential biotherapeutic agents. Studies are warranted to experimentally examine the efficacy of flavonoid metabolites directly, as they emerge as novel therapeutic options.

show abstract

Section: Flavonoid Clinical Trialsmentioning

confidence: 99%

The Potential of Flavonoids and Flavonoid Metabolites in the Treatment of Neurodegenerative Pathology in Disorders of Cognitive Decline

Melrose

2023

Antioxidants

View full text Add to dashboard Cite

show abstract

“…[78,79] It has also been shown to improve muscle stiffness in middle-aged and elderly individuals with lowintensity resistance exercise. [80] Supplementation with Omega-3 fatty acids can reduce muscle wasting and increase strength in women, particularly older women with sarcopenia. [83][84][85]99] Interestingly, researches indicate that there may be a gender difference in the anti-muscular atrophy effect of fish oil, as women showed a greater improvement in muscle mass after exercise training compared to men.…”

Section: Antioxidant Supplementsmentioning

confidence: 99%

“…Improved muscle mass and grip strength in chronic kidney disease mice when combined with dasatinib [ 76] Attenuated muscle mass loss in cachectic mice [ 77] Protected against eccentric exercise-induced muscular impairment in human [ 78,79] Quercetin glycoside supplementation improved muscle stiffness in Japanese middle-aged and elderly population with low-intensity resistance exercise [ 80] Omega-3 fatty acids Inhibits oxidative stress and inflammation Regulates FTO/m6A/DDIT4/PGC-1𝛼 pathway…”

Section: Antioxidant Supplementsmentioning

confidence: 99%

Nutritional Strategies for Muscle Atrophy: Current Evidence and Underlying Mechanisms

Shen,

Zhang,

Dai

et al. 2024

Molecular Nutrition Food Res

View full text Add to dashboard Cite

Skeletal muscle can undergo detrimental changes in various diseases, leading to muscle dysfunction and atrophy, thus severely affecting people's lives. Along with exercise, there is a growing interest in the potential of nutritional support against muscle atrophy. This review provides a brief overview of the molecular mechanisms driving skeletal muscle atrophy and summarizes recent advances in nutritional interventions for preventing and treating muscle atrophy. The nutritional supplements include amino acids and their derivatives (such as leucine, β‐hydroxy, β‐methylbutyrate, and creatine), various antioxidant supplements (like Coenzyme Q10 and mitoquinone, resveratrol, curcumin, quercetin, Omega 3 fatty acids), minerals (such as magnesium and selenium), and vitamins (such as vitamin B, vitamin C, vitamin D, and vitamin E), as well as probiotics and prebiotics (like Lactobacillus, Bifidobacterium, and 1‐kestose). Furthermore, the study discusses the impact of a combined approach involving nutritional support and physical therapy to prevent muscle atrophy, suggests appropriate multi‐nutritional and multi‐modal interventions based on individual conditions to optimize treatment outcomes, and enhances the recovery of muscle function for patients. By understanding the molecular mechanisms behind skeletal muscle atrophy and implementing appropriate interventions, it is possible to enhance the recovery of muscle function and improve patients' quality of life.

show abstract

“…It is particularly noteworthy that quercetin promotes behavioral functional recovery by hastening the recovery of weight in damaged muscles and increasing neuronal intrinsic growth capacity following sciatic nerve crush injury in mice [194]. In addition, in middle-aged and older adults, the administration of quercetin glycoside together with low-intensity resistance exercise improves muscle quality (an increase in muscle stiffness) and independent muscle quantity [195].…”

Section: Quercetinmentioning

confidence: 99%

Sarcopenic Obesity: Involvement of Oxidative Stress and Beneficial Role of Antioxidant Flavonoids

Jung

2023

Antioxidants

View full text Add to dashboard Cite

Sarcopenic obesity, which refers to concurrent sarcopenia and obesity, is characterized by decreased muscle mass, strength, and performance along with abnormally excessive fat mass. Sarcopenic obesity has received considerable attention as a major health threat in older people. However, it has recently become a health problem in the general population. Sarcopenic obesity is a major risk factor for metabolic syndrome and other complications such as osteoarthritis, osteoporosis, liver disease, lung disease, renal disease, mental disease and functional disability. The pathogenesis of sarcopenic obesity is multifactorial and complicated, and it is caused by insulin resistance, inflammation, hormonal changes, decreased physical activity, poor diet and aging. Oxidative stress is a core mechanism underlying sarcopenic obesity. Some evidence indicates a protective role of antioxidant flavonoids in sarcopenic obesity, although the precise mechanisms remain unclear. This review summarizes the general characteristics and pathophysiology of sarcopenic obesity and focuses on the role of oxidative stress in sarcopenic obesity. The potential benefits of flavonoids in sarcopenic obesity have also been discussed.

show abstract

Effects of Quercetin Glycoside Supplementation Combined With Low-Intensity Resistance Training on Muscle Quantity and Stiffness: A Randomized, Controlled Trial

Cited by 7 publications

References 41 publications

The Potential of Flavonoids and Flavonoid Metabolites in the Treatment of Neurodegenerative Pathology in Disorders of Cognitive Decline

The Potential of Flavonoids and Flavonoid Metabolites in the Treatment of Neurodegenerative Pathology in Disorders of Cognitive Decline

Nutritional Strategies for Muscle Atrophy: Current Evidence and Underlying Mechanisms

Sarcopenic Obesity: Involvement of Oxidative Stress and Beneficial Role of Antioxidant Flavonoids

Contact Info

Product

Resources

About