Effects of quercetin on apoptosis and extracellular matrix degradation of chondrocytes induced by oxidative stress‐mediated pyroptosis

Wang, Qing; Ying, Lujing; Wei, Bing; Ji, Yikui; Xu, Yi

doi:10.1002/jbt.22951

Cited by 23 publications

(11 citation statements)

References 40 publications

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“…This molecule was tested in different models of OA Wistar rats, showing that quercetin can reduce LPS-induced apoptosis and ECM degradation by inhibiting NLRP3-mediated pyroptosis. 106 …”

Section: Other Potential Future Directions For Inflammasome Targeting...mentioning

confidence: 99%

Targeting inflammasome-dependent mechanisms as an emerging pharmacological approach for osteoarthritis therapy

et al. 2022

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“…This molecule was tested in different models of OA Wistar rats, showing that quercetin can reduce LPS-induced apoptosis and ECM degradation by inhibiting NLRP3-mediated pyroptosis. 106 …”

Section: Other Potential Future Directions For Inflammasome Targeting...mentioning

confidence: 99%

Targeting inflammasome-dependent mechanisms as an emerging pharmacological approach for osteoarthritis therapy

et al. 2022

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“…Formononetin is one of the major active components of Astragalus membranaceus [20], and it shows a wide range of physiological effects beneficial to health through estrogen dependent and independent mechanisms [21]. Quercetin is a natural flavonoid compound with a variety of biological activities, and it [22]. Kaempferol, also known as polyphenols, is a type of flavonoids seen in many plants.…”

Section: Discussionmentioning

confidence: 99%

Mechanism of Xinfeng Capsule in the Treatment of Hypercoagulable State of Ankylosing Spondylitis Based on Data Mining and Network Pharmacology

Liu

Fang

et al. 2022

BioMed Research International

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Background. Ankylosing spondylitis (AS) is a rheumatism that mainly affects the axial bones and joints. Xinfeng capsule (XFC) is a preparation with a remarkable clinical effect that is used in our hospital. And it has definite curative effect and less side effects in the treatment of AS. Objective. Data mining and network pharmacology were used to analyze the efficacy of Chinese medicine Xinfeng capsule on treating the hypercoagulable state of ankylosing spondylitis and the underlying mechanism behind it. Methods. Clinical data were collected and compiled from the Department of Rheumatology and Immunology of the First Affiliated Hospital of Anhui University of Chinese Medicine. Cluster analysis was used to investigate herbs that frequently used to treat AS, Apriori module was used to analyze the association rules between herbs and laboratory indexes, and the random walk model was used to reveal the therapeutic efficacy of XFC against AS. The TCMSP database was used to acquire the active components and targets of XFC, and the GeneCards and OMIM database were used to obtain the targets of AS. Afterward, an active ingredient-target network was established and core targets were screened for; overlapping targets were screened for the protein-protein interaction (PPI) network analysis, the Gene Ontology (GO) enrichment analysis, and the Kyoto Encyclopedia of Genes and Genomes (KEGG) pathway analysis. Molecular docking was adopted to investigate the interactions between main active components and core targets. Results. Frequently used herbs could be divided into three groups, and according to the analysis of Apriori module, there is a strong correlation between XFC and the improvement of ESR and hs-CRP, and the results of the random walk model demonstrated that the effect of XFC on improving PLT, ESR, and hs-CRP was superior to the use of traditional Chinese medicine alone. In total, 103 active compounds of XFC and 59 overlapping targets were obtained. The PPI relationships were obtained through the STRING database, and 13 core targets were identified. 1786 GO enrichment results and 205 KEGG enrichment results were obtained, including NF-kappa B signaling pathway, TNF signaling pathway, and IL17 signaling pathway. The outcomes of molecular docking revealed a close relationship between the active compounds of XFC and core targets. Conclusion. This study demonstrated that XFC can effectively improve the hypercoagulable state and the inflammatory indices of AS patients through data mining, and it has a strong correlation with the clinical improvement of inflammation. The active compounds of formononetin, triptolide, quercetin, and kaempferol may be the key active components of XFC in regulating AS, possibly through inhibiting the activation of NF-kappa B signaling pathway to improve hypercoagulable state.

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“…Icariin (ICA) exerts a similar function by inhibiting NLRP3-caspase 1 axis [173]. Quercetin blocks oxidative stress-induced pyroptosis in the LPS-induced OA model [174], and morroniside exerts similar properties [49].…”

Section: Exosomes Treatmentmentioning

confidence: 99%

The regulatory role and therapeutic application of pyroptosis in musculoskeletal diseases

Wang

Feng

et al. 2022

Cell Death Discov.

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Pyroptosis is a controlled form of inflammatory cell death characterized by inflammasome activation, pore formation, and cell lysis. According to different caspases, pyroptosis can be divided into canonical, non-canonical, and other pathways. The role of pyroptosis in disease development has been paid more attention in recent years. The trigger factors of pyroptosis are often related to oxidative stress and proinflammatory substances, which coincide with the pathological mechanism of some diseases. Pyroptosis directly leads to cell lysis and death, and the release of cytosolic components and proinflammatory cytokines affects cell activity and amplifies the inflammatory response. All the above are involved in a series of basic pathological processes, such as matrix degradation, fibrosis, and angiogenesis. Since these pathological changes are also common in musculoskeletal diseases (MSDs), emerging studies have focused on the correlations between pyroptosis and MSDs in recent years. In this review, we first summarized the molecular mechanism of pyroptosis and extensively discussed the differences and crosstalk between pyroptosis, apoptosis, and necrosis. Next, we elaborated on the role of pyroptosis in some MSDs, including osteoarthritis, rheumatoid arthritis, osteoporosis, gout arthritis, ankylosing spondylitis, intervertebral disc degeneration, and several muscle disorders. The regulation of pyroptosis could offer potential therapeutic targets in MSDs treatment. Herein, the existing drugs and therapeutic strategies that directly or indirectly target pyroptosis pathway components have been discussed in order to shed light on the novel treatment for MSDs.

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Effects of quercetin on apoptosis and extracellular matrix degradation of chondrocytes induced by oxidative stress‐mediated pyroptosis

Cited by 23 publications

References 40 publications

Targeting inflammasome-dependent mechanisms as an emerging pharmacological approach for osteoarthritis therapy

Targeting inflammasome-dependent mechanisms as an emerging pharmacological approach for osteoarthritis therapy

Mechanism of Xinfeng Capsule in the Treatment of Hypercoagulable State of Ankylosing Spondylitis Based on Data Mining and Network Pharmacology

The regulatory role and therapeutic application of pyroptosis in musculoskeletal diseases

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