Effects of quercetin on oxidative stress and memory retrieval in kindled rats

Nassiri‐Asl, Marjan; Moghbelinejad, Sahar; Abbasi, Esmail; Yonesi, Fatemeh; Haghighi, Mohammad-Reza; Lotfizadeh, Mina; Bazahang, Parisa

doi:10.1016/j.yebeh.2013.04.019

Cited by 69 publications

(39 citation statements)

References 43 publications

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“…The results of biochemical studies confirmed a state of increased oxidative stress in the brain of kindled mice. These observations are in line with earlier reports in which kindling and AED treatment were responsible for increasing TBARS levels, decreasing GSH levels, and decreasing CAT activity [8,13,58,[67][68][69][70][71]. The combined treatment of the subeffective dose of phenytoin with curcumin and flavonoid-rich fraction exhibited attenuation of oxidative stress in the brains of kindled mice.…”

Section: Discussionsupporting

confidence: 92%

Ficus religiosa L. figs — A potential herbal adjuvant to phenytoin for improved management of epilepsy and associated behavioral comorbidities

Singh

Goel

2014

Epilepsy & Behavior

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Section: Discussionsupporting

confidence: 92%

Ficus religiosa L. figs — A potential herbal adjuvant to phenytoin for improved management of epilepsy and associated behavioral comorbidities

Singh

Goel

2014

Epilepsy & Behavior

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“…These data suggest that although the antioxidant activity of the extracts studied has been attributed to their metabolite content, the differences between the extracts may be due not only to their compositions. We must also consider the presence of other mechanisms that regulate the hyperexcitability induced by KA, such as positive modu-latory effects of flavonoids on inhibitory-type GABAergic neurotransmission [28][29][30] as well as modulatory effects on serotoninergic responses, which have been considered responsible for the effects of some flavonoids on responses to sedation and anxiolytics [31]. The exact anticonvulsant mechanism of action ME of H. inuloides remains unknown, but flavonoid metabolites such as quercetin are present [22], and it has not been ruled out that the anticonvulsant effect observed against KA-induced seizures can be attributed to both anticonvulsant and antioxidant capacities, which have been reported for this extract and its metabolite [22,32].…”

Section: Discussionmentioning

confidence: 99%

Dose-Dependent Behavioral and Antioxidant Effects of Quercetin and Methanolic and Acetonic Extracts fromHeterotheca inuloideson Several Rat Tissues following Kainic Acid-InducedStatus Epilepticus

Carmona-Aparicio¹,

Cárdenas-Rodríguez²,

Delgado³

et al. 2019

Oxidative Medicine and Cellular Longevity

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Kainic acid (KA) has been used to study the neurotoxicity induced after status epilepticus (SE) due to activation of excitatory amino acids with neuronal damage. Medicinal plants can protect against damage caused by KA-induced SE; in particular, organic extracts of Heterotheca inuloides and its metabolite quercetin display antioxidant activity and act as hepatoprotective agents. However, it is unknown whether these properties can protect against the hyperexcitability underlying the damage caused by KA-induced SE. Our aim was to study the protective effects (with regard to behavior and antioxidant activity) of administration of natural products methanolic (ME) and acetonic (AE) extracts and quercetin (Q) from H. inuloides at doses of 30 mg/kg (ME30, AE30, and Q30 groups), 100 mg/kg (ME100, AE100, and Q100 groups), and 300 mg/kg (ME300, AE300, and Q300 groups) against damage in brain regions of male Wistar rats treated with KA. We found dose-dependent effects on behavioral and biochemical studies in the all-natural product groups vs. the control group, with decreases in seizure severity (Racine’s scale) and increases in seizure latency (p<0.05 in the ME100, AE100, Q100, and Q300 groups and p<0.01 in the AE300 and ME300 groups); on lipid peroxidation and carbonylated proteins in all brain tissues (p<0.0001); and on GPx, GR, CAT, and SOD activities with all the treatments vs. KA (p≤0.001). In addition, there were strong negative correlations between carbonyl levels and latency in the group treated with KA and in the group treated with methanolic extract in the presence of KA (r=‐0.9919, p=0.0084). This evidence suggests that organic extracts and quercetin from H. inuloides exert anticonvulsant effects via direct scavenging of reactive oxygen species (ROS) and modulation of antioxidant enzyme activity.

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“…All guidelines and recommendations of the European Communities Council Directive of 24 November 1986 (86/609/EEC) were followed for minimising the number of rats used and their suffering. Following general anaesthesia using intramuscular ketamine/xylazine (60 mg/kg and 6 mg/kg, respectively) as described previously (20), the rats had a laparotomy with a 5 cm midline incision. Then, to stimulate the formation of intra-abdominal adhesions, using the method described by Liebman et al (4), parts of the antral and dorsal cecum and its adjacent abdominal wall were scratched with a sterile gauze to induce punctate bleeding.…”

Section: Methodsmentioning

confidence: 99%

Comparing Lavage of the Peritoneal Cavity with Lidocaine, Bupivacaine and Normal Saline to Reduce the Formation of Abdominal Adhesion Bands in Rats

Parsa

Saravani

Sameei-Rad

et al. 2017

MJMS

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Background: Intra-abdominal adhesions are fibrous bands that develop after abdominal surgery or inflammation and cause mortality and morbidity following surgeries. This study aimed to assess the effects of bupivacaine, saline and two doses of lidocaine, after peritoneal lavage and to compare their effects in reducing abdominal adhesions in rat.Methods: In a blinded, randomised, placebo-controlled clinical trial, 50 female rats were anaesthetised and the parietal peritoneum was scratched to induce punctate bleeding. The rats were randomly assigned to five groups: saline, lidocaine 2% (3 and 6 mg/kg), bupivacaine 0.25% (2 mg/kg) and control (no irrigation). The peritoneal cavity was irrigated with the appropriate solution during laparotomy. Two weeks later, re-laparotomy was performed. The quantity, quality, severity and scores of adhesions were recorded and compared.Results: The quantity and quality of adhesions were significantly higher in the control group than in the lidocaine (6 mg/kg) and bupivacaine groups. The quality of the adhesions was higher in the normal saline group than in the lidocaine (6 mg/kg) and bupivacaine groups. The severity of adhesions between the lidocaine 3 and 6 mg/kg groups and between the lidocaine 3 mg/ kg and saline groups was lower than that in the control group.Conclusion: Using lidocaine (6 mg/kg) and bupivacaine lavage in first laparotomy reduces abdominal peritoneal obstruction because of the formation of adhesion bands.

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Effects of quercetin on oxidative stress and memory retrieval in kindled rats

Cited by 69 publications

References 43 publications

Ficus religiosa L. figs — A potential herbal adjuvant to phenytoin for improved management of epilepsy and associated behavioral comorbidities

Ficus religiosa L. figs — A potential herbal adjuvant to phenytoin for improved management of epilepsy and associated behavioral comorbidities

Dose-Dependent Behavioral and Antioxidant Effects of Quercetin and Methanolic and Acetonic Extracts fromHeterotheca inuloideson Several Rat Tissues following Kainic Acid-InducedStatus Epilepticus

Comparing Lavage of the Peritoneal Cavity with Lidocaine, Bupivacaine and Normal Saline to Reduce the Formation of Abdominal Adhesion Bands in Rats

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