Effects of quercetin on tenderness, apoptotic and autophagy signalling in chickens during post-mortem ageing

Wang, Tongting; Feng, Xianchao; Li, Linzi; Luo, Jun; Liu, Xuebo; Zheng, Jun; Fan, Xiaojing; Liu, Yaping; Xu, Xinglian; Chen, Lin

doi:10.1016/j.foodchem.2022.132409

Cited by 24 publications

(21 citation statements)

References 43 publications

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“…(2014) , consumers are willing to choose more tender flesh. In general, flesh tenderness is usually expressed as shear force, and there is a negative correlation between tenderness and shear force ( Wang et al., 2022 ). So, the muscle tenderness of grass carp was obviously promoted by dietary TM ( Table 8 ).…”

Section: Discussionmentioning

confidence: 99%

Improving flesh quality of grass carp (Ctenopharyngodon idellus) by completely replacing dietary soybean meal with yellow mealworm (Tenebrio molitor)

Li¹,

Xue²,

Sun³

et al. 2023

Animal Nutrition

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Section: Discussionmentioning

confidence: 99%

Improving flesh quality of grass carp (Ctenopharyngodon idellus) by completely replacing dietary soybean meal with yellow mealworm (Tenebrio molitor)

Li¹,

Xue²,

Sun³

et al. 2023

Animal Nutrition

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“…The contribution of apoptosis theory in meat ageing has received great attention in recent years [6][7] . After slaughter, animals are drained of almost all blood in a very short time, and in such cases, the myocytes of the animal body are inevitably in a state of hypoxia and ischemia, leading to apoptosis and autophagy [8] . Apoptosis refers to the cell receiving apoptotic signals, coordinating the activities of a series of apoptotic enzymes and apoptotic factors to transduce the signals, and finally completing the death of cells [9] .…”

Section: Food Science and Human Wellnessmentioning

confidence: 99%

“…Abnormal protein synthesis in the ER, imbalance in calcium homeostasis, and dysfunction of the ER all lead to ER stress [13] . Postmortem hypoxia and ischemia will damage the homeostasis of the internal environment, thus it can cause ER stress [8] . However, whether ER stress plays a role in meat tenderization during postmortem ageing is unclear.…”

Section: Food Science and Human Wellnessmentioning

confidence: 99%

Endoplasmic reticulum stress improved chicken tenderness, promoted apoptosis and autophagy during postmortem ageing

Chai,

Chen,

Xiang

et al. 2024

Food Science and Human Wellness

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In this study, endoplasmic reticulum (ER) stress inducer tunicamycin (TM) and inhibitor 4-phenylbutyric acid (4-PBA) were used to treat postmortem chicken breast muscle to investigate changes in tenderness and effects on apoptosis and autophagy during 5 days ageing. TM-induced ER stress reduced shear force, enhanced myofibril fragmentation index (MFI), disrupted myofibril structure, increased desmin degradation, and activated μ-calpain and caspase-12. In addition, TM-induced ER stress increased the expression of Bax, Bim, and cytochrome c, and decreased the expression of Bcl-xL. Furthermore, TM-induced ER stress improved the conversion of LC3I to LC3II, raised the expression of Beclin-1, and decreased the expression of p62, PI3K, and mTOR. The opposite results were observed after 4-PBA treatment. These results suggested that ER stress could improve chicken tenderness, promote apoptosis and autophagy during chicken postmortem ageing.

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“…The PI3K/AKT/mTOR signal pathway is involved in quercetin-induced autophagy and apoptosis. These results suggest that quercetin can promote meat tenderness and activate apoptosis and autophagy pathways during the aging process of chickens after death [ 73 ].…”

Section: Antiaging Activitymentioning

confidence: 99%

Pharmacological Activity of Quercetin: An Updated Review

Wang

Yao

et al. 2022

Evidence-Based Complementary and Alternative Medicine

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Quercetin, a natural flavonoid compound with a widespread occurrence throughout the plant kingdom, exhibits a variety of pharmacological activities. Because of the wide spectrum of health-promoting effects, quercetin has attracted much attention of dietitians and medicinal chemists. An updated review of the literature on quercetin was performed using PubMed, Embase, and Science Direct databases. This article presents an overview of recent developments in pharmacological activities of quercetin including anti-SARS-CoV-2, antioxidant, anticancer, antiaging, antiviral, and anti-inflammatory activities as well as the mechanism of actions involved. The biological activities of quercetin were evaluated both in vitro and in vivo, involving a number of cell lines and animal models, but metabolic mechanisms of quercetin in the human body are not clear. Therefore, further large sample clinical studies are needed to determine the appropriate dosage and form of quercetin for the treatment of the disease.

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Effects of quercetin on tenderness, apoptotic and autophagy signalling in chickens during post-mortem ageing

Cited by 24 publications

References 43 publications

Improving flesh quality of grass carp (Ctenopharyngodon idellus) by completely replacing dietary soybean meal with yellow mealworm (Tenebrio molitor)

Improving flesh quality of grass carp (Ctenopharyngodon idellus) by completely replacing dietary soybean meal with yellow mealworm (Tenebrio molitor)

Endoplasmic reticulum stress improved chicken tenderness, promoted apoptosis and autophagy during postmortem ageing

Pharmacological Activity of Quercetin: An Updated Review

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