2001
DOI: 10.1046/j.1442-2042.2001.00389.x
|View full text |Cite
|
Sign up to set email alerts
|

Effects of quercetin on the heat‐induced cytotoxicity of prostate cancer cells

Abstract: Background: It has been demonstrated that prostate cancer cells are relatively sensitive to heat stress. We have reported that heat treatment at 43°C increases the expression of heat shock protein 70 (hsp70) in prostate cancer cells, leading to apoptosis. Hsp70 is a protein that protects cells against heat damage. Cells with lower levels of hsp70 have been shown to have a higher sensitivity to heat stress. Therefore, downregulation of hsp70 is expected to enhance heat-induced inhibitory effects on cell growth.… Show more

Help me understand this report

Search citation statements

Order By: Relevance

Paper Sections

Select...
2
1
1

Citation Types

1
15
0

Year Published

2003
2003
2023
2023

Publication Types

Select...
8
1

Relationship

0
9

Authors

Journals

citations
Cited by 24 publications
(16 citation statements)
references
References 17 publications
1
15
0
Order By: Relevance
“…Cellular factors belonging to this category are HSP complexes that participate in holding inactive HSF1, GR, and p53 proteins in the cytoplasm but are not likely to be involved in regulation of NF-B that couples instead with its "own" specific inhibitor I-B. Many properties of HSPs and HSP inhibitors (such as quercetin, a flavanoid that shares structural similarity with PFT␣ (24)) are consistent with the potential involvement of HSPs in PFT␣ activity. HSPs are common participants of different apoptotic pathways, and they are induced by a variety of stress agents, including UV and gamma radiation, HS, glucocorticoids, cytotoxic drugs, etc.…”
Section: Pft␣ Inhibits Heat Shock and Glucocorticoid Pathways 15467mentioning
confidence: 76%
See 1 more Smart Citation
“…Cellular factors belonging to this category are HSP complexes that participate in holding inactive HSF1, GR, and p53 proteins in the cytoplasm but are not likely to be involved in regulation of NF-B that couples instead with its "own" specific inhibitor I-B. Many properties of HSPs and HSP inhibitors (such as quercetin, a flavanoid that shares structural similarity with PFT␣ (24)) are consistent with the potential involvement of HSPs in PFT␣ activity. HSPs are common participants of different apoptotic pathways, and they are induced by a variety of stress agents, including UV and gamma radiation, HS, glucocorticoids, cytotoxic drugs, etc.…”
Section: Pft␣ Inhibits Heat Shock and Glucocorticoid Pathways 15467mentioning
confidence: 76%
“…(17,25). Moreover, cells could be protected from gamma or UV radiation induced apoptosis by exposure to HS or overexpression of HSP70 (17,26), while quercetin, an HSP inhibitor, is known to enhance apoptosis in a variety of systems (24,27). Thus, HSPs are obvious candidate targets of PFT␣, and this hypothesis remains to be experimentally tested.…”
Section: Pft␣ Inhibits Heat Shock and Glucocorticoid Pathways 15467mentioning
confidence: 99%
“…Quercetin, a major bioflavonoid in human diet, has been identified as a chemotherapeutic agent for the treatment of breast cancer (Singhal et al, 1995;Choi et al, 2001), colon cancer (Salucci et al, 2002), ovarian cancer (Chan et al, 2003) and prostate cancer (Knowles et al, 2000;Nakanoma et al, 2001;Kobayashi et al, 2002). Antiproliferative action of quercetin is hypothesised to be mediated by attenuating phosphorylation of activated hsp transcription factor (hsf), shortly after its trimerisation (Nagai et al, 1995;Lee et al, 1998), thereby resulting in increased susceptibility of hsf to proteolytic degradation and as a consequence inhibiting all downstream events, including hsp expression (Li et al, 1999).…”
mentioning
confidence: 99%
“…37 In accord with reduction of Hsp70 expression, Quercetin induces apoptosis in several tumor cells and renders cells more susceptible to apoptotic inducers. 38 Although Quercetin has been reported to inhibit the induction of Hsp70 synthesis at the mRNA level, the inhibitory mechanism has not been clearly established. 39,40 Overall, in spite of its evident utility in cancer treatment, Quercetin is not potent enough for clinical use (i.e., potency is often observed at 100-500 mM).…”
Section: Hsp70 Assay Validation: Inhibitors Of Expression Of Endogenomentioning
confidence: 99%