Effects of quercetin on the neuromotor function and behavioral responses of Wistar and Zucker rats fed a high-fat and high-carbohydrate diet

Mzhel'skaya, K V; Шипелин, В А; Шумакова, А А; Musaeva, A D; Soto, Jorge S.; Ригер, Н. А.; Трусов, Н В; Kirbaeva, N. V.; Apryatin, S A; Gmoshinski, I. V.

doi:10.1016/j.bbr.2019.112270

Cited by 17 publications

(16 citation statements)

References 26 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…The reported significant increase in leptin in HFDinduced obese rats compared to that in lean rats (Table 4) is in good agreement with the previous work of Lin et al [37], who showed that obesity induced by an HFD in C57 B1/6J mice may occur in three stages: an early response to the HFD due to exogenous leptin sensitivity, lowered food intake when leptin production increases and the brain remains sensitive to leptin, and finally, an elevated intake of food with reduced central sensitivity to leptin. This observation can also be supported by the most recent work of Mzhelskaya et al [38], in which it was reported that in HFD-induced obesity, leptin loses its anorexigenic effect on neurons of the hypothalamus, consequently increasing appetite and fat mass accumulation.…”

Section: Discussionsupporting

confidence: 64%

High-fat diet-induced obesity and impairment of brain neurotransmitter pool

Labban

Alfawaz

Almnaizel

et al. 2020

Translational Neuroscience

View full text Add to dashboard Cite

AbstractObesity and the brain are linked since the brain can control the weight of the body through its neurotransmitters. The aim of the present study was to investigate the effect of high-fat diet (HFD)-induced obesity on brain functioning through the measurement of brain glutamate, dopamine, and serotonin metabolic pools. In the present study, two groups of rats served as subjects. Group 1 was fed a normal diet and named as the lean group. Group 2 was fed an HFD for 4 weeks and named as the obese group. Markers of oxidative stress (malondialdehyde, glutathione, glutathione-s-transferase, and vitamin C), inflammatory cytokines (interleukin [IL]-6 and IL-12), and leptin along with a lipid profile (cholesterol, triglycerides, high-density lipoprotein, and low-density lipoprotein levels) were measured in the serum. Neurotransmitters dopamine, serotonin, and glutamate were measured in brain tissue. Fecal samples were collected for observing changes in gut flora. In brain tissue, significantly high levels of dopamine and glutamate as well as significantly low levels of serotonin were found in the obese group compared to those in the lean group (P > 0.001) and were discussed in relation to the biochemical profile in the serum. It was also noted that the HFD affected bacterial gut composition in comparison to the control group with gram-positive cocci dominance in the control group compared to obese. The results of the present study confirm that obesity is linked to inflammation, oxidative stress, dyslipidemic processes, and altered brain neurotransmitter levels that can cause obesity-related neuropsychiatric complications.

show abstract

Section: Discussionsupporting

confidence: 64%

High-fat diet-induced obesity and impairment of brain neurotransmitter pool

Labban

Alfawaz

Almnaizel

et al. 2020

Translational Neuroscience

View full text Add to dashboard Cite

show abstract

“…Assessing the level of anxiety-like behavior and the state of short-term and long-term memory in the conditioned passive avoidance response test (CRPA) was evaluated on the 39th, 40th, and 60th days of the experiment. Behavioral responses studies were carried out on the equipment of the Panlab Harvard Apparatus (Spain) using the methods and parameters fully described earlier [ 34 ].…”

Section: Methodsmentioning

confidence: 99%

Effects of Tyrosine and Tryptophan in Rats with Diet-Induced Obesity

Шипелин

Трусов

Apryatin

et al. 2021

IJMS

Self Cite

View full text Add to dashboard Cite

Amino acids tyrosine (Tyr) and tryptophan (Trp) play a significant role in the regulation of energy metabolism, locomotor activity, and eating behavior. We studied the possibility of modulating these processes in obesity by increasing the pool of Tyr and Trp in the experimental diet. As a model of obesity, we used Wistar rats fed a diet with an excess specific energy value (HFCD) for 64 days. Trp led to a normalization of the rats’ body weight almost to the control level, but increased anxiety-like behavior and decreased long-term memory. The consumption of amino acids resulted in increased grip strength and impairment of short-term memory. The locomotor activity of animals decreased with age as a result of Tyr consumption, while Trp, on the contrary, prevented this. The Tyr supplementation led to the normalization of triglycerides and LDL. In the spleen cell lysates, amino acids suppressed the production of proinflammatory cytokines. The liver tissue morphology showed that the consumption of Tyr noticeably weakened the signs of fatty degeneration. The addition of Trp, on the contrary, led to an unfavorable effect, consisting of the appearance of a high number of large rounded fatty vacuoles. The data obtained indicate a more pronounced anti-inflammatory effect of Tyr as compared to Trp.

show abstract

“…Leptin is an important cytokine that plays a key role in regulating lipid metabolism, promoting inflammation, and accelerating aortic valve calcification in patients with coronary heart disease [56]. Mzhelskaya et al found that Qu can reduce cholesterol levels and lipid levels in high fat and fructose diet rats by regulating leptin-mediated lipid reception [57]. But, the study does not directly clarify the attenuating effect of Qu on cholesterol synthesis; the possible mechanism is that Qu regulate the negative feedback mechanism between fat deposits and fat catabolism rate through leptin, thus promoting the process of lipid metabolism and glucose metabolism and reducing cholesterol intake in rats [57].…”

Section: Lipid Metabolism-modulating Propertiesmentioning

confidence: 99%

Therapeutic Potential of Quercetin as an Antiatherosclerotic Agent in Atherosclerotic Cardiovascular Disease: A Review

Deng

Fang

et al. 2020

Evidence-Based Complementary and Alternative Medicine

View full text Add to dashboard Cite

Atherosclerotic cardiovascular disease (ASCVD) is one of the diseases with the highest morbidity and mortality globally. It causes a huge burden on families and caregivers and high costs for medicine and surgical interventions. Given expensive surgeries and failures of most conventional treatments, medical community tries to find a more cost-effective cure. Thus, attentions have been primarily focused on food or herbs. Quercetin (Qu) extracted from food, a flavonoid component, develops potentials of alternative or complementary medicine in atherosclerosis. Due to the wide range of health benefits, researchers have considered to apply Qu as a natural compound in therapy. This review is aimed to identify the antiatherosclerosis functions of Qu in treating ASCVD such as anti-inflammatory, antioxidant properties, effects on endothelium-dependent vasodilation, and blood lipid-lowering.

show abstract

Effects of quercetin on the neuromotor function and behavioral responses of Wistar and Zucker rats fed a high-fat and high-carbohydrate diet

Cited by 17 publications

References 26 publications

High-fat diet-induced obesity and impairment of brain neurotransmitter pool

High-fat diet-induced obesity and impairment of brain neurotransmitter pool

Effects of Tyrosine and Tryptophan in Rats with Diet-Induced Obesity

Therapeutic Potential of Quercetin as an Antiatherosclerotic Agent in Atherosclerotic Cardiovascular Disease: A Review

Contact Info

Product

Resources

About